The aim of the study was to analyze craniofacial growth during adolescence from 12 to 21 years and to explore correlation with the late crowding of mandibular incisors. The study included 61 orthodontically untreated subjects (49% males) from the Nittedal Growth Study. The lateral cephalograms were used to assess the sagittal and vertical jaw growth and inclination of the incisors. The Little index and the anterior arch depth were measured on plaster casts of mandibular dentition. In both sexes there is a significant increase in the angles of maxillary and mandibular prognatism with a large effect size (η2=0.526-0.567; p<0.001) and a reduction of the skeletal class angle, which is significant only in male (η2=0.188; p=0.015). From the age of the 12 to 21 years there is a significant reduction in skeletal vertical dimension in both sexes (η2=0.527-0.593, p<0.001). The lower incisors tend to retrocline in both sexes, while the upper tend to procline in male and retrocline in females. The anterior mandibular arch depth reduction is significant between 12 and 21 years in both sexes (η2=0.259, p<0.05). From 12 to 21 years, a significant increase in the Little's index of irregularity for an average 2.0±2.0 mm (95% CI 2.5-1.5; η2=0.488; p<0.001) is observed and the finding is similar in both sexes. The degree of change of crowding correlates only with the degree of skeletal change, and the correlation is negative weak linear (r=-0.290, p=0.023). An increase of ANB angle by 1° from 12 to 21 years decreases the degree of crowding by 0.5 mm in the same period. Differential growth of the maxilla and mandible is associated with the occurance of late crowding but there is a large interindividual variability