prikaz prve stranice dokumenta Genetic variation in tissue inhibitors of metalloproteinases as a risk factor for idiopathic recurrent spontaneous abortion
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Scientific paper - Original scientific paper
Genetic variation in tissue inhibitors of metalloproteinases as a risk factor for idiopathic recurrent spontaneous abortion
Fertility and Sterility, 99 (2013), 7; 1923-1929. https://doi.org/10.1016/j.fertnstert.2013.02.018
Pereza, Nina; Volk, Marija; Zrakić, Nikolina; Kapović, Miljenko; Peterlin, Borut; Ostojić, Saša

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Pereza, N., Volk, M., Zrakić, N., Kapović, M., Peterlin, B. & Ostojić, S. (2013). Genetic variation in tissue inhibitors of metalloproteinases as a risk factor for idiopathic recurrent spontaneous abortion. Fertility and Sterility, 99. (7), 1923-1929. doi: 10.1016/j.fertnstert.2013.02.018

Pereza, Nina, et al. "Genetic variation in tissue inhibitors of metalloproteinases as a risk factor for idiopathic recurrent spontaneous abortion." Fertility and Sterility, vol. 99, no. 7, 2013, pp. 1923-1929. https://doi.org/10.1016/j.fertnstert.2013.02.018

Pereza, Nina, Marija Volk, Nikolina Zrakić, Miljenko Kapović, Borut Peterlin and Saša Ostojić. "Genetic variation in tissue inhibitors of metalloproteinases as a risk factor for idiopathic recurrent spontaneous abortion." Fertility and Sterility 99, no. 7 (2013): 1923-1929. https://doi.org/10.1016/j.fertnstert.2013.02.018

Pereza, N., et al. (2013) 'Genetic variation in tissue inhibitors of metalloproteinases as a risk factor for idiopathic recurrent spontaneous abortion', Fertility and Sterility, 99(7), pp. 1923-1929. doi: 10.1016/j.fertnstert.2013.02.018

Pereza N, Volk M, Zrakić N, Kapović M, Peterlin B, Ostojić S. Genetic variation in tissue inhibitors of metalloproteinases as a risk factor for idiopathic recurrent spontaneous abortion. Fertility and Sterility [Internet]. 2013 [cited 2024 November 11];99(7):1923-1929. doi: 10.1016/j.fertnstert.2013.02.018

N. Pereza, M. Volk, N. Zrakić, M. Kapović, B. Peterlin and S. Ostojić, "Genetic variation in tissue inhibitors of metalloproteinases as a risk factor for idiopathic recurrent spontaneous abortion", Fertility and Sterility, vol. 99, no. 7, pp. 1923-1929, 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:563045. [Accessed: 11 November 2024]

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Metadata
Title (english)Genetic variation in tissue inhibitors of metalloproteinases as a risk factor for idiopathic recurrent spontaneous abortion
AuthorNina Pereza
AuthorMarija Volk
AuthorNikolina Zrakić
AuthorMiljenko Kapović
AuthorBorut Peterlin
AuthorSaša Ostojić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
Objective: To investigate the potential association of tissue inhibitor of metalloproteinases (TIMP) 1, 2, 3, and 4 gene polymorphisms with idiopathic recurrent spontaneous abortion (IRSA). Design: Case-control and association study. Setting: Departments of gynecology and obstetrics and university-based research laboratory. Patient(s): A total of 149 couples with a history of three or more idiopathic spontaneous pregnancy losses and 149 fertile men and 149 fertile women with at least two live births and no history of pregnancy pathologies. Intervention(s): Polymerase chain reaction and restriction-fragment-length polymorphism methods. Main Outcome Measure(s): Detection of TIMP-1 372 C/T, TIMP-2 303 C/T, TIMP-3 915 A/G, TIMP-3 1296 C/T, and TIMP-4 30 -UTR C/T genotypes and allele frequencies. Result(s): There were no statistically significant differences in the distribution of any genotype and allele frequencies or any genetic model between IRSA patients and controls. Additionally, no significant associations occurred between combinations of TIMP polymorphisms and the risk of IRSA. Conclusion(s): We found no evidence for the association of TIMP-1, -2, -3, and -4 with IRSA in a Slovenian population.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleFertility and Sterility
Numberingvol. 99, no. 7, pp. 1923-1929
p-ISSN0015-0282
DOIhttps://doi.org/10.1016/j.fertnstert.2013.02.018
URN:NBNurn:nbn:hr:184:563045
Publication2013
Document URLhttp://www.fertstert.org/article/S0015-0282(13)00275-6/pdf
Type of resourceText
Access conditionsClosed access
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Created on2017-08-02 09:47:56