prikaz prve stranice dokumenta IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.
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Scientific paper - Original scientific paper
IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.
PLoS Pathogens, 13 (2017), 4; e1006345. https://doi.org/10.1371/journal.ppat.1006345
Popović, Branka; Golemac, Mijo; Podlech, J.; Železnjak, Jelena; Bilić-Zulle, Lidija; Lukić, M.L.; Čičin-Šain, Luka; Reddehase, M.J.; Sparwasser, T.; Krmpotić, Astrid; Jonjić, Stipan

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Popović, B., Golemac, M., Podlech, J., Železnjak, J., Bilić Zulle, L., Lukić, M. ... Jonjić, S. (2017). IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.. PLoS Pathogens, 13. (4). doi: 10.1371/journal.ppat.1006345

Popović, Branka, et al. "IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.." PLoS Pathogens, vol. 13, no. 4, 2017. https://doi.org/10.1371/journal.ppat.1006345

Popović, Branka, Mijo Golemac, J. Podlech, Jelena Železnjak, Lidija Bilić Zulle, M.L. Lukić, Luka Čičin Šain, et al. "IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.." PLoS Pathogens 13, no. 4 (2017). https://doi.org/10.1371/journal.ppat.1006345

Popović, B., et al. (2017) 'IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.', PLoS Pathogens, 13(4). doi: 10.1371/journal.ppat.1006345

Popović B, Golemac M, Podlech J, Železnjak J, Bilić Zulle L, Lukić M, and sur.. IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.. PLoS Pathogens [Internet]. 2017 April 27 [cited 2024 December 10];13(4). doi: 10.1371/journal.ppat.1006345

B. Popović, et al., "IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.", PLoS Pathogens, vol. 13, no. 4, April 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:239373. [Accessed: 10 December 2024]

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Metadata
Title (english)IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.
AuthorBranka Popović
AuthorMijo Golemac
AuthorJ. Podlech
AuthorJelena Železnjak
AuthorLidija Bilić-Zulle
AuthorM.L. Lukić
AuthorLuka Čičin-Šain
AuthorM.J. Reddehase
AuthorT. Sparwasser
AuthorAstrid Krmpotić
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Treg cells are crucial for immune homeostasis and for dampening immune response to several diseased conditions, including viral infections. Murine cytomegalovirus (MCMV) is a herpesvirus with pathogenic potential, so that early immune mechanisms are essential in controlling virus and protecting from virus-induced pathology. Studies on Foxp3+ Treg cells have revealed their inhibitory role on the early T cell response to MCMV infection and have suggested Treg cells as a target of MCMV’s immunoevasion mechanisms. Here we demonstrate that the number and activation status of liver Treg cells is strongly induced upon MCMV infection in order to protect the host from severe liver damage. They constitutively express high amounts of IL-33 receptor ST2 and their accumulation depends on IL-33, which is released as a tissue alarmin after the cell damage. For the first time, we show an immunoregulatory role of IL-33-dependent Treg cells in the liver of MCMV infected mice and their suppression of MCMV-induced immunopathology.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePLoS Pathogens
Numberingvol. 13, no. 4, e1006345
p-ISSN1553-7366
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1006345
URN:NBNurn:nbn:hr:184:239373
Publication2017-04-27
ProjectNumber: 322693
Title (english): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Acronym: STADVINN
Jurisdiction: eu
Funding stream: FP7
Document URLhttps://doi.org/10.1371/journal.ppat.1006345
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-06-20 11:45:11