prikaz prve stranice dokumenta The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.
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Scientific paper - Original scientific paper
The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.
PLoS Pathogens, 13 (2017), 5; e1006382.. https://doi.org/10.1371/journal.ppat.1006382
Chan, Baca; Magalhães, V. G.; Lemmermann, N.A.W.; Juranić Lisnić, Vanda; Stempel, M.; Bussey, .K.A.; Reimer, E.; Podlech, J.; Lienenklaus, S.; Reddehase, M.J.; Jonjić, Stipan; Brinkmann, Melanie M.

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Chan, B., Magalhães, V. G., Lemmermann, N., Juranić Lisnić, V., Stempel, M., Bussey, .. ... Brinkmann, M. M. (2017). The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.. PLoS Pathogens, 13. (5). doi: 10.1371/journal.ppat.1006382

Chan, Baca, et al. "The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.." PLoS Pathogens, vol. 13, no. 5, 2017. https://doi.org/10.1371/journal.ppat.1006382

Chan, Baca, V. G. Magalhães, N.A.W. Lemmermann, Vanda Juranić Lisnić, M. Stempel, .K.A. Bussey, E. Reimer, et al. "The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.." PLoS Pathogens 13, no. 5 (2017). https://doi.org/10.1371/journal.ppat.1006382

Chan, B., et al. (2017) 'The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.', PLoS Pathogens, 13(5). doi: 10.1371/journal.ppat.1006382

Chan B, Magalhães VG, Lemmermann N, Juranić Lisnić V, Stempel M, Bussey ., and sur.. The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.. PLoS Pathogens [Internet]. 2017 May 25 [cited 2024 September 09];13(5). doi: 10.1371/journal.ppat.1006382

B. Chan, et al., "The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.", PLoS Pathogens, vol. 13, no. 5, May 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:436021. [Accessed: 09 September 2024]

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Metadata
Title (english)The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.
AuthorBaca Chan
AuthorV. G. Magalhães
AuthorN.A.W. Lemmermann
AuthorVanda Juranić Lisnić
AuthorM. Stempel
Author.K.A. Bussey
AuthorE. Reimer
AuthorJ. Podlech
AuthorS. Lienenklaus
AuthorM.J. Reddehase
AuthorStipan Jonjić
AuthorMelanie M. Brinkmann
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The herpesvirus cytomegalovirus can cause severe morbidity in immunosuppressed people and poses a much greater global problem in the context of congenital infections than the Zika virus. To establish infection, cytomegalovirus needs to modulate the antiviral immune response of its host. One of the first lines of defense against viral infections is the type I interferon response which is activated by cellular sensors called pattern recognition receptors. These receptors sense viral entry and rapidly induce the transcription of type I interferons, which are instrumental for the induction of an antiviral state in infected and surrounding cells. We have identified the first viral protein encoded by murine cytomegalovirus, the M35 protein, that counteracts type I interferon transcription downstream of multiple pattern recognition receptors. We found that this viral countermeasure occurs shortly after viral entry into the host cell, as M35 is delivered with the viral particle. M35 then localizes to the nucleus where it modulates NF-κB-mediated transcription. In vivo, murine cytomegalovirus deficient of the M35 protein replicates to lower levels in spleen and liver and cannot establish a productive infection in the salivary glands, which is a key site of viral transmission, highlighting the important role of M35 for the establishment of infection. Our study provides novel insights into the complex interaction between cytomegalovirus and the innate immune response of its host.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePLoS Pathogens
Numberingvol. 13, no. 5, e1006382.
p-ISSN1553-7366
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1006382
URN:NBNurn:nbn:hr:184:436021
Publication2017-05-25
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444856/pdf/ppat.1006382.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-06-19 16:31:57