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Professional paper - Review paper
Uloga virusa u nastanku malignih tumora kod ljudi
Medicina Fluminensis : Medicina Fluminensis, 47 (2011), 3; 275-280. urn:nbn:hr:184:008390
Periša, Darinka; Brajac, Ines; Poljak, Ivica

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Periša, D., Brajac, I. & Poljak, I. (2011). Uloga virusa u nastanku malignih tumora kod ljudi. Medicina Fluminensis : Medicina Fluminensis, 47. (3), 275-280. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:008390

Periša, Darinka, et al. "Uloga virusa u nastanku malignih tumora kod ljudi." Medicina Fluminensis : Medicina Fluminensis, vol. 47, no. 3, 2011, pp. 275-280. https://urn.nsk.hr/urn:nbn:hr:184:008390

Periša, Darinka, Ines Brajac and Ivica Poljak. "Uloga virusa u nastanku malignih tumora kod ljudi." Medicina Fluminensis : Medicina Fluminensis 47, no. 3 (2011): 275-280. https://urn.nsk.hr/urn:nbn:hr:184:008390

Periša, D., Brajac, I. and Poljak, I. (2011) 'Uloga virusa u nastanku malignih tumora kod ljudi', Medicina Fluminensis : Medicina Fluminensis, 47(3), pp. 275-280. Available at: https://urn.nsk.hr/urn:nbn:hr:184:008390 (Accessed 22 November 2024)

Periša D, Brajac I, Poljak I. Uloga virusa u nastanku malignih tumora kod ljudi. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2011 September 05 [cited 2024 November 22];47(3):275-280. Available at: https://urn.nsk.hr/urn:nbn:hr:184:008390

D. Periša, I. Brajac and I. Poljak, "Uloga virusa u nastanku malignih tumora kod ljudi", Medicina Fluminensis : Medicina Fluminensis, vol. 47, no. 3, pp. 275-280, September 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:008390. [Accessed: 22 November 2024]

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Metadata
Title (croatian)Uloga virusa u nastanku malignih tumora kod ljudi
Title (english)The role of viruses in human carcinogenesis
AuthorDarinka Periša
AuthorInes Brajac
AuthorIvica Poljak
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (croatian)
Procjenjuje se da virusne infekcije pridonose nastanku 15 – 20 % svih malignih tumora ljudi. Kao obligatorni intracelularni paraziti, virusi kodiraju proteine koji reprogramiraju signalne puteve odgovorne za kontrolu proliferacije, diferencijacije, smrti stanice, genomskog integriteta, kao i prepoznavanja od strane imunološkog sustava. Virusni sustavi podržavaju koncept da je za razvoj tumora potrebna akumulacija međusobno povezanih događaja. Virusi koji su do sada prihvaćeni kao etiološki čimbenici ljudskih malignoma uključuju hepatitis B virus, Epstein-Barr virus, humani papiloma virus, virus leukemije ljudskih T-stanica, hepatitis C virus, te još nekoliko ljudskih onkogenih virusa. Obično protekne niz godina od infekcije do razvoja tumora i većina inficiranih osoba ne razvije rak, iako imunološki kompromitirane osobe pokazuju veći rizik za nastanak tumora povezanih s virusima. Malo je vjerojatno da je virus sam dovoljan da transformira normalnu stanicu u tumorsku. Vjerojatnija je mogućnost da kombinirano djelovanje virusnih proteina i mutacije staničnih gena zajedno vode tumorogenezi.
Abstract (english)
It is estimated that viral infections contribute to 15-20 % of all human cancers. As obligatory intracellular parasites, viruses encode proteins which reprogramme host cellular signalling pathways which in turn control proliferation, differentiation, cell death, genomic integrity, and recognition by the immune system. Viral systems support the concept that cancer development occurs by accumulation of multiple cooperating events. Viruses are now accepted as etiologic factors of human cancer, and include hepatitis B virus, Epstein-Barr virus, human papillomaviruses, human T-cell leukemia virus and hepatitis C virus, plus several candidate human cancer viruses. Many years may pass between initial infection and tumor appearance. Most infected individuals do not develop cancer, although immunocompromised individuals are at elevated risk of viral-associated cancers. It is unlikely that a tumor virus is sufficient to convert a normal cell to a tumor cell. Rather, a combination of the action of viral proteins and cellular gene mutation cooperate to drive tumorogenesis.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 47, no. 3, pp. 275-280
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:008390
Publication2011-09-05
Document URLhttp://hrcak.srce.hr/71755
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-05-10 10:05:32