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Scientific paper - review paper
Genetička analiza mikrodelecija AZF područja kromosoma Y u muškaraca s kliničkom dijagnozom shizofrenije
Medicina Fluminensis : Medicina Fluminensis, 47 (2011), 1; 120-124. urn:nbn:hr:184:983382
Nadarević, Tin; Buretić-Tomljanović, Alena

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Nadarević, T. & Buretić Tomljanović, A. (2011). Genetička analiza mikrodelecija AZF područja kromosoma Y u muškaraca s kliničkom dijagnozom shizofrenije. Medicina Fluminensis : Medicina Fluminensis, 47. (1), 120-124. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:983382

Nadarević, Tin and Alena Buretić Tomljanović. "Genetička analiza mikrodelecija AZF područja kromosoma Y u muškaraca s kliničkom dijagnozom shizofrenije." Medicina Fluminensis : Medicina Fluminensis, vol. 47, no. 1, 2011, pp. 120-124. https://urn.nsk.hr/urn:nbn:hr:184:983382

Nadarević, Tin and Alena Buretić Tomljanović. "Genetička analiza mikrodelecija AZF područja kromosoma Y u muškaraca s kliničkom dijagnozom shizofrenije." Medicina Fluminensis : Medicina Fluminensis 47, no. 1 (2011): 120-124. https://urn.nsk.hr/urn:nbn:hr:184:983382

Nadarević, T. and Buretić Tomljanović, A. (2011) 'Genetička analiza mikrodelecija AZF područja kromosoma Y u muškaraca s kliničkom dijagnozom shizofrenije', Medicina Fluminensis : Medicina Fluminensis, 47(1), pp. 120-124. Available at: https://urn.nsk.hr/urn:nbn:hr:184:983382 (Accessed 29 November 2024)

Nadarević T, Buretić Tomljanović A. Genetička analiza mikrodelecija AZF područja kromosoma Y u muškaraca s kliničkom dijagnozom shizofrenije. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2011 March 07 [cited 2024 November 29];47(1):120-124. Available at: https://urn.nsk.hr/urn:nbn:hr:184:983382

T. Nadarević and A. Buretić Tomljanović, "Genetička analiza mikrodelecija AZF područja kromosoma Y u muškaraca s kliničkom dijagnozom shizofrenije", Medicina Fluminensis : Medicina Fluminensis, vol. 47, no. 1, pp. 120-124, March 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:983382. [Accessed: 29 November 2024]

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Title (croatian)Genetička analiza mikrodelecija AZF područja kromosoma Y u muškaraca s kliničkom dijagnozom shizofrenije
Title (english)Genetic analysis of Y-chromosome microdeletions in men with a clinical diagnosis of schizophrenia
AuthorTin Nadarević
AuthorAlena Buretić-Tomljanović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (croatian)
Cilj: Stopa plodnosti bolesnika s dijagnozom shizofrenije značajno je niža negoli u općoj populaciji. Smanjenoj stopi plodnosti pridonose spol, bračni status, reproduktivna dob, socioekonomski, kulturni, ali i genetički čimbenici. U ovom smo radu pretpostavili genetičku povezanost shizofrenije i smanjene plodnosti muških bolesnika. Ispitanici i metode: U uzorku od 105 muškaraca s kliničkom dijagnozom shizofrenije (prema DSM-IV) i 100 kontrolnih muškaraca ispitali smo prisutnost mikrodelecija područja čimbenika azoospermije (AZF) kromosoma Y kako bismo utvrdili pridonose li spomenute mikrodelecije riziku i/ili smanjenoj plodnosti muških bolesnika. Ispitivani STS-biljezi (engl. sequence tagged sites) AZF područja jesu: sY86, sY134, sY255, te sY84, sY127, sY254 koji su analizirani dvjema multipleks lančanim reakcijama polimeraze. Kao kontrolni lokusi korišteni su STS-biljeg sY14 (Yp) i presudoautosomni lokus ZFX/ZFY. Rezultati: Mikrodelecije kromosoma Y nismo pronašli niti u uzorku bolesnika niti u kontroli. Zaključak: Mikrodelecije AZF područja kromosoma Y ne pridonose riziku niti smanjenoj plodnosti muškaraca oboljelih od shizofrenije.
Abstract (english)
Aim: Fertility rate of patients with schizophrenia is lower than in the general population. The contributing factors are sex, marital status, reproductive age, socioeconomic, cultural, and genetic factors. In this work, we tested the possible genetic association between schizophrenia and lower fertility rate of male patients. Patients and methods: DNA samples taken from 105 male patients with clinical diagnosis of schizophrenia (according to DSM-IV criteria) and 100 control men were analysed for the presence of chromosome Y azoospermia factor (AZF) microdeletions. Six sequence tagged sites (STS) spanning AZFa-c region were analysed using two multiplex polymerase chain reactions: sY84, sY127, sY254, and sY86, sY134, sY255. STS-marker sY14 (Yp) and pseudoautosomal locus ZFX/ZFY were used as control loci in both reactions. Results: No evidence of AZF-microdeletions were found in both groups. Conclusion: Microdeletions of the chromosome Y AZF-region do not contribute to the risk or reduced fertility rate in males with schizophrenia.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeScientific paper - review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 47, no. 1, pp. 120-124
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:983382
Publication2011-03-07
Document URLhttp://hrcak.srce.hr/66100
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-05-10 09:16:48