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Scientific paper - Original scientific paper
Relationship Between Gut Microbiota and the Clinical Course of COVID-19 Disease
Viruses, 17 (2025), 4; 520. https://doi.org/10.3390/v17040520
Jonjić, Antonija; Dolanc, Ivan; Slivšek, Goran; Bočkor, Luka; Tarle, Marko; Mustapić, Sanda; Kmet, Marta; Orehovec, Biserka; Kučan Brlić, Paola; Cokarić Brdovčak, Maja; Obad, Ante; Walenta, Martin; Dražić, Ivan; Bilić-Zulle, Lidija; Lukšić, Ivica; Bulić, Neven; Goessler, Walter; Jonjić, Stipan; Čoklo, Miran; Žučko, Jurica More authors...

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Jonjić, A., Dolanc, I., Slivšek, G., Bočkor, L., Tarle, M., Mustapić, S. ... Žučko, J. (2025). Relationship Between Gut Microbiota and the Clinical Course of COVID-19 Disease. Viruses, 17. (4). doi: 10.3390/v17040520

Jonjić, Antonija, et al. "Relationship Between Gut Microbiota and the Clinical Course of COVID-19 Disease." Viruses, vol. 17, no. 4, 2025. https://doi.org/10.3390/v17040520

Jonjić, Antonija, Ivan Dolanc, Goran Slivšek, Luka Bočkor, Marko Tarle, Sanda Mustapić, Marta Kmet, et al. "Relationship Between Gut Microbiota and the Clinical Course of COVID-19 Disease." Viruses 17, no. 4 (2025). https://doi.org/10.3390/v17040520

Jonjić, A., et al. (2025) 'Relationship Between Gut Microbiota and the Clinical Course of COVID-19 Disease', Viruses, 17(4). doi: 10.3390/v17040520

Jonjić A, Dolanc I, Slivšek G, Bočkor L, Tarle M, Mustapić S, and sur.. Relationship Between Gut Microbiota and the Clinical Course of COVID-19 Disease. Viruses [Internet]. 2025 April 02 [cited 2025 April 10];17(4). doi: 10.3390/v17040520

A. Jonjić, et al., "Relationship Between Gut Microbiota and the Clinical Course of COVID-19 Disease", Viruses, vol. 17, no. 4, April 2025. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:791446. [Accessed: 10 April 2025]

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Metadata
Title (english)Relationship Between Gut Microbiota and the Clinical Course of COVID-19 Disease
AuthorAntonija Jonjić
AuthorIvan Dolanc
AuthorGoran Slivšek
AuthorLuka Bočkor
AuthorMarko Tarle
AuthorSanda Mustapić
AuthorMarta Kmet
AuthorBiserka Orehovec
AuthorPaola Kučan Brlić
AuthorMaja Cokarić Brdovčak
AuthorAnte Obad
AuthorMartin Walenta
AuthorIvan Dražić
AuthorLidija Bilić-Zulle
AuthorIvica Lukšić
AuthorNeven Bulić
AuthorWalter Goessler
AuthorStipan Jonjić
AuthorMiran Čoklo
AuthorJurica Žučko
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Possible early detection of people at increased risk for severe COVID-19 clinical course is extremely important so that appropriate therapy can be initiated promptly to prevent numerous deaths. Our study included 45 patients treated for COVID-19 at Dubrava University Hospital, with clinical course analysed from medical records and stool samples collected for determination of the gut microbiota diversity using 16S rRNA analysis. Sequencing was successful for 41 samples belonging to four clinical... More course groups (WHO guidelines): 12 samples—critical, 12—severe, 9—moderate and 8—mild group. Microbial composition was assessed between groups using two approaches—ANCOM (QIIME2) and Kruskal–Wallis (MicrobiomeAnalyst). On the genus level, two taxa were found to be differentially abundant: archaeal Halococcus and Coprococcus (for both W = 37)—the two were most abundant in the critical group (10% and 0.94% of entire abundance, respectively). Coprococcus catus was the only species identified by both methods to be differentially abundant between groups and was most abundant in the critical group. Alpha diversity indicated greater evenness of features in the critical group. Beta diversity showed clustering of samples from the critical group. A relationship between gut microbiota composition and the clinical course of COVID-19 disease was indicated, pointing towards specific distinct features of the critical group. In a broader sense, our findings might be useful in combating potential future similar pandemics and emerging virus outbreaks. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleViruses
Numberingvol. 17, no. 4, 520
e-ISSN1999-4915
DOIhttps://doi.org/10.3390/v17040520
URN:NBNurn:nbn:hr:184:791446
Publication2025-04-02
Document URLhttps://www.mdpi.com/1999-4915/17/4/520
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-04-03 07:05:10
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