prikaz prve stranice dokumenta Autoimmune Thyroid Disease and Pregnancy: The Interaction Between Genetics, Epigenetics and Environmental Factors
  Download
PDF 1.53 MB
Scientific paper - Review paper
Autoimmune Thyroid Disease and Pregnancy: The Interaction Between Genetics, Epigenetics and Environmental Factors
Journal of Clinical Medicine, 14 (2025), 1; 190. https://doi.org/10.3390/jcm14010190
Bogović Crnčić, Tatjana; Ćurko-Cofek, Božena; Batičić, Lara; Girotto, Neva; Tomaš, Maja Ilić; Kršek, Antea; Krištofić, Ines; Štimac, Tea; Perić, Ivona; Sotošek, Vlatka; Klobučar, Sanja

Cite this document

Bogović Crnčić, T., Ćurko Cofek, B., Batičić, L., Girotto, N., Tomaš, M. I., Kršek, A. ... Klobučar, S. (2025). Autoimmune Thyroid Disease and Pregnancy: The Interaction Between Genetics, Epigenetics and Environmental Factors. Journal of Clinical Medicine, 14. (1). doi: 10.3390/jcm14010190

Bogović Crnčić, Tatjana, et al. "Autoimmune Thyroid Disease and Pregnancy: The Interaction Between Genetics, Epigenetics and Environmental Factors." Journal of Clinical Medicine, vol. 14, no. 1, 2025. https://doi.org/10.3390/jcm14010190

Bogović Crnčić, Tatjana, Božena Ćurko Cofek, Lara Batičić, Neva Girotto, Maja Ilić Tomaš, Antea Kršek, Ines Krištofić, et al. "Autoimmune Thyroid Disease and Pregnancy: The Interaction Between Genetics, Epigenetics and Environmental Factors." Journal of Clinical Medicine 14, no. 1 (2025). https://doi.org/10.3390/jcm14010190

Bogović Crnčić, T., et al. (2025) 'Autoimmune Thyroid Disease and Pregnancy: The Interaction Between Genetics, Epigenetics and Environmental Factors', Journal of Clinical Medicine, 14(1). doi: 10.3390/jcm14010190

Bogović Crnčić T, Ćurko Cofek B, Batičić L, Girotto N, Tomaš MI, Kršek A, and sur.. Autoimmune Thyroid Disease and Pregnancy: The Interaction Between Genetics, Epigenetics and Environmental Factors. Journal of Clinical Medicine [Internet]. 2025 January [cited 2025 January 22];14(1). doi: 10.3390/jcm14010190

T. Bogović Crnčić, et al., "Autoimmune Thyroid Disease and Pregnancy: The Interaction Between Genetics, Epigenetics and Environmental Factors", Journal of Clinical Medicine, vol. 14, no. 1, January 2025. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:508639. [Accessed: 22 January 2025]

Please login to the repository to save this object to your list.
Metadata
Title (english)Autoimmune Thyroid Disease and Pregnancy: The Interaction Between Genetics, Epigenetics and Environmental Factors
AuthorTatjana Bogović Crnčić
AuthorBožena Ćurko-Cofek
AuthorLara Batičić
AuthorNeva Girotto
AuthorMaja Ilić Tomaš
AuthorAntea Kršek
AuthorInes Krištofić
AuthorTea Štimac
AuthorIvona Perić
AuthorVlatka Sotošek
AuthorSanja Klobučar
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Nuclear Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Autoimmune thyroid disease (AITD) is the leading cause of thyroid dysfunction globally, characterized primarily by two distinct clinical manifestations: Hashimoto’s thyroiditis (HT) and Graves’ disease (GD). The prevalence of AITD is approximately twice as high in women compared to men, with a particularly pronounced risk during the reproductive years. Pregnancy exerts profound effects on thyroid physiology and immune regulation due to hormonal fluctuations and immune adaptations aimed at fostering maternal–fetal tolerance, potentially triggering or exacerbating AITD. The impact of AITD on pregnancy outcomes is multifaceted. Both HT and GD have been associated with adverse obstetric and neonatal outcomes, including miscarriage, preterm delivery, preeclampsia and fetal growth restriction. Inadequately managed AITD can also affect fetal neurodevelopment due to disrupted maternal thyroid hormone availability during critical periods of brain maturation. This review explores the complex interplay between the genetic, epigenetic and environmental factors that drive AITD during pregnancy, highlighting their roles in disease development and impacts on pregnancy outcomes. Gaining a deeper understanding of these mechanisms is crucial for improving diagnostic tools, treatment options and preventive measures to enhance the health and well-being of both the mother and the newborn.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Clinical Medicine
Numberingvol. 14, no. 1, 190
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm14010190
URN:NBNurn:nbn:hr:184:508639
Publication2025-01
ProjectNumber: uniri-iskusni-biomed-23-61
Title (croatian): Dinamičke promjene stanica prirođene imunosti u trudnica s autoimunom bolesti štitne žlijezde
Title (english): Dynamic changes of innate immune cells in pregnant women with autoimmune thyroid disease
Leader: Tatjana Bogović Crnčić
Jurisdiction: Croatia
Document URLhttps://www.mdpi.com/2077-0383/14/1/190
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-01-10 12:02:06