prikaz prve stranice dokumenta Radical Prostatectomy with Extended Pelvic Lymphadenectomy: Impact of Separate Vs. En Bloc Lymph Node Submission on Pathohistological Analysis
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Scientific paper - Original scientific paper
Radical Prostatectomy with Extended Pelvic Lymphadenectomy: Impact of Separate Vs. En Bloc Lymph Node Submission on Pathohistological Analysis
Acta clinica Croatica, 63. (2024), Supplement 2; 45-50. https://doi.org/10.20471/acc.2024.63.s2.7
Srok, Dorian; Đorđević, Gordana; Markić, Dean; Španjol, Josip; Krpina, Kristian

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Srok, D., Đorđević, G., Markić, D., Španjol, J. & Krpina, K. (2024). Radical Prostatectomy with Extended Pelvic Lymphadenectomy: Impact of Separate Vs. En Bloc Lymph Node Submission on Pathohistological Analysis. Acta clinica Croatica, 63.. (Supplement 2), 45-50. doi: 10.20471/acc.2024.63.s2.7

Srok, Dorian, et al. "Radical Prostatectomy with Extended Pelvic Lymphadenectomy: Impact of Separate Vs. En Bloc Lymph Node Submission on Pathohistological Analysis." Acta clinica Croatica, vol. 63., no. Supplement 2, 2024, pp. 45-50. https://doi.org/10.20471/acc.2024.63.s2.7

Srok, Dorian, Gordana Đorđević, Dean Markić, Josip Španjol and Kristian Krpina. "Radical Prostatectomy with Extended Pelvic Lymphadenectomy: Impact of Separate Vs. En Bloc Lymph Node Submission on Pathohistological Analysis." Acta clinica Croatica 63., no. Supplement 2 (2024): 45-50. https://doi.org/10.20471/acc.2024.63.s2.7

Srok, D., et al. (2024) 'Radical Prostatectomy with Extended Pelvic Lymphadenectomy: Impact of Separate Vs. En Bloc Lymph Node Submission on Pathohistological Analysis', Acta clinica Croatica, 63.(Supplement 2), pp. 45-50. doi: 10.20471/acc.2024.63.s2.7

Srok D, Đorđević G, Markić D, Španjol J, Krpina K. Radical Prostatectomy with Extended Pelvic Lymphadenectomy: Impact of Separate Vs. En Bloc Lymph Node Submission on Pathohistological Analysis. Acta clinica Croatica [Internet]. 2024 [cited 2024 December 09];63.(Supplement 2):45-50. doi: 10.20471/acc.2024.63.s2.7

D. Srok, G. Đorđević, D. Markić, J. Španjol and K. Krpina, "Radical Prostatectomy with Extended Pelvic Lymphadenectomy: Impact of Separate Vs. En Bloc Lymph Node Submission on Pathohistological Analysis", Acta clinica Croatica, vol. 63., no. Supplement 2, pp. 45-50, 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:892145. [Accessed: 09 December 2024]

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Title (english)Radical Prostatectomy with Extended Pelvic Lymphadenectomy: Impact of Separate Vs. En Bloc Lymph Node Submission on Pathohistological Analysis
Title (croatian)Radikalna prostatektomija s proširenom zdjeličnom limfadenektomijom: utjecaj odvojenog vs. zajedničkog slanja limfnih čvorova na patohistološku analizu
AuthorDorian Srok
AuthorGordana Đorđević
AuthorDean Markić
AuthorJosip Španjol
AuthorKristian Krpina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract (english)
Introduction: In prostate cancer (PC), it is well established that the wider the anatomical template of dissection, the higher the number of lymph nodes (LNs) retrieved, and the higher the nodal yield, the better the detection of metastasis1,2. Objectives: The objectives of this study were to evaluate if the change in submission methodology (en bloc vs. separate) had an impact on the number of total LNs identified per patient and the number of positive LNs found, and to determine the impact of individual pathologists on the number of total LNs and positive LNs. Patients and methods: We performed a retrospective analysis of hospital records of patients with PC in whom radical prostatectomy (RP) with pelvic lymphadenectomy (PLND) was done in the period from November 2012 to December 2018. We used only a single-surgeon series in order to avoid performance bias in the lymphadenectomy template. Pathohistological examinations were performed by our hospital’s two dedicated urogenital pathologists. Patients were divided into high and intermediate risk groups according to the European Association of Urology (EAU) guidelines, based on submission methodology of the lymphadenectomy tissue and by the pathologist performing the examinations. The number of LNs and number of positive LNs acquired were then compared using the Mann-Whitney test. Results: Patients who underwent separate submission of lymphadenectomy tissue had a significantly higher nodal yield, but there was no difference in the number of positive LNs. There was no significant difference in the total number of LNs acquired and LN metastases detected between our two pathologists when comparing them by submission technique. Conclusions: Separate submission of lymphadenectomy tissue resulted in a higher nodal yield, but it did not translate to a higher number of positive LNs found.
Abstract (croatian)
UVOD: U raku prostate od ranije je ustanovljeno što su širi anatomski rubovi disekcije limfnih čvorova više limfnih čvorova je nađeno, a što je veći ukupan broj limfnih čvorova bolje se otkrivaju metastaze u istima.(1,2) CILJEVI: Ciljevi ove studije bili su istražiti da li promjena u metodi uzorkovanja (u odvojenim spremnicima vs en bloc) ima utjecaja na ukupan broj limfnih čvorova otkrivenih po pacijentu i na broj otkrivenih pozitivnih limfnih čvorova te koji je utjecaj pojedinog patologa na ukupan broj limnih čvorova i broj pozitivnih limfnih čvorova. MATERIJALI I METODE: U ovoj retrospektivnoj analizi koristili smo podatke iz bolničke arhive za sve pacijente kojima je učinjena radikalna prostatektomija sa zdjeličnom limfadenektomijom u periodu od studenog 2012 do prosinca 2018 u Kliničkom bolničkom centru Rijeka. Koristili smo podatke pacijenata koji su imali istog vodećeg kirurga da bi izbjegli individualni utjecaj pojedinog kirurga na anatomski opseg limfadenektomije. Dva urogenitalna patologa naše bolnice su provela sve patohistološke preglede. Pacijenti su bili podijeljeni na bolest visokog i srednjeg rizika prema smjernicama Europske udruge urologa (EAU), zatim prema metodi uzorkovanja limfadenektomijskog tkiva i prema patologu koji je proveo patohistološku analizu. Ukupan broj limfnih čvorova i broj pozitivnih limfnih čvorova je zatim uspoređen koristeći Mann Whitney test. REZULTATI: Kada se tkivo limfadenektomije uzorkuje u odvojenim spremnicima otkrije se značajno više limfnih čvorova, ali nema razlike u broju nađenih metastaza u limfnim čvorovima. Kada smo uspoređivali naše patologe, nije bilo značajne razlike u broju nađenih limfnih čvorova niti u broju otkrivenih metastaza u limfne čvorove kada se uspoređuju prema metodi uzorkovanja limfadenektomijskog tkiva. ZAKLJUČAK: Uzorkovanje limfadenektomijskog tkiva u odvojenim spremnicima rezultira većim ukupnim brojem nađenih limfnih čvorova, ali ne dovodi do većeg broja nađenih metastaza u limfne čvorove.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 63., no. Supplement 2, pp. 45-50
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2024.63.s2.7
URN:NBNurn:nbn:hr:184:892145
Publication2024
Document URLhttps://hrcak.srce.hr/323127
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-12-09 14:40:17