Definition of Mechanical Circulatory Support (MCS) refers to a group of mechanical devices that can be added to the physiological circulation to provide support or replace the function of the heart and/or lungs. This allows for adequate blood flow and oxygenation in situations where pharmacological support is insufficient. In this study, a retrospective analysis was conducted on patients undergoing percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG), who required mechanical circulatory support during one of these procedures. The analysis was conducted from 2021 to 2024. The mechanical circulatory support devices analyzed in this study were ECMO, Impella, and iVACL2. A retrospective cohort analysis compared the treatment outcomes of patients, along with other factors that could influence the primary variable. A total of 35 patients were included in the study, with an average age of 67 years and 82.86% (n=29) male. Of the total number of patients, 68.57% (n=24) were on ECMO, 14.29% (n=5) on Impella, and 17.14% (n=6) on iVACL2. The results showed that the highest mortality was in patients on ECMO support, with a survival rate of 29.17% (n=7). The main causes of death were irreversible shock (significantly higher compared to iVAC patients) and sepsis (significantly higher compared to iVAC and Impella patients). However, the results also showed that ECMO patients had more comorbidities, were subjected to more invasive CABG procedures, were mostly significantly hemodynamically unstable upon admission, and the duration of ECMO support was mostly longer than 48 hours, contributing to a higher risk of complications. To draw more concrete conclusions, it is necessary to publish new studies from other centers and include a much larger number of participants. Such studies could one day truly provide guidelines for potential improvements in the treatment of critical patients with ischemic heart disease.