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master's thesis
Nealkoholna masna bolest jetre
2024. urn:nbn:hr:184:166892
Kovačević, Manuela
University of Rijeka
Faculty of Medicine
Department of Internal Medicine

Cite this document

Kovačević, M. (2024). Nealkoholna masna bolest jetre (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:166892

Kovačević, Manuela. "Nealkoholna masna bolest jetre." Master's thesis, University of Rijeka, Faculty of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:184:166892

Kovačević, Manuela. "Nealkoholna masna bolest jetre." Master's thesis, University of Rijeka, Faculty of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:184:166892

Kovačević, M. (2024). 'Nealkoholna masna bolest jetre', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 15 July 2024, https://urn.nsk.hr/urn:nbn:hr:184:166892

Kovačević M. Nealkoholna masna bolest jetre [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2024 [cited 2024 July 15] Available at: https://urn.nsk.hr/urn:nbn:hr:184:166892

M. Kovačević, "Nealkoholna masna bolest jetre", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:184:166892

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Metadata
TitleNealkoholna masna bolest jetre
Title (english)Non-alcoholic fatty liver disease
AuthorManuela Kovačević
MentorGoran Poropat (mentor)
Committee memberSandra Milić (predsjednik povjerenstva)
Committee memberTamara Turk Wensveen (član povjerenstva)
Committee memberVanja Licul (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Rijeka
Defense date and country2024-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Nealkoholna masna bolest jetre definirana je prisutnošću steatoze i metaboličkih rizičnih čimbenika te odsutnošću pretjerane konzumacije alkohola i ostalih jetrenih bolesti. Prevalencija nealkoholne masne bolesti jetre u svijetu u odraslih osoba je 25%. Brojni genetički i okolišni čimbenici se isprepliću i u svake osobe tvore individualnu kombinaciju patogenetskih čimbenika koji djeluju na pojedinca uzrokujući kliničku sliku NAFLD-a. NAFLD je heterogena bolest s različitim stopama progresije i ishodom. U većine pacijenata nealkoholna masna bolest jetre je stabilna ili sporo progresivna i neće prijeći u cirozu. NAFLD obuhvaća spektar bolesti od nealkoholne steatoze s blagom upalom ili bez upale do nealkoholnog steatohepatitisa kojeg karakterizira upala i brža progresija do fibroze. U pravilu, pacijenti s NAFLD-om su asimptomatski. Komplikacije bolesti su portalna hipertenzija, hepatocelularni karcinom, kardiovaskularne i maligne bolesti. Vodeći uzroci smrti u osoba s NAFLD-om su kardiovaskularna bolest i ekstrahepatalne maligne bolesti (kolorektalni karcinom i karcinom dojke). Razvijene su neinvazivne metode koje imaju prednost nad biopsijom, a njihova učinkovitost u procjeni stanja bolesti iznimno je visoka. Budući da nema odobrene terapije, a pronađena je povezanost između metaboličkih čimbenika (pretilost, inzulinska rezistencija, šećerna bolest, hiperlipidemija) i nastanka NAFLD-a i progresije, racionalno rješenje je usmjeravanje terapije prema liječenju metaboličkih čimbenika.
Abstract (english)
Non-alcoholic fatty liver disease is defined by presence of steatosis in association with metabolic risk factors and in absence of excessive alcohol intake or other liver diseases. World prevalence of NAFLD is 20% in adults. Genetic and environmental factors interplay and form individual combination of pathogenetic factors which cause clinically manifested NAFLD. NAFLD is heterogenous disease with different progression and different outcome. Non-alcoholic fatty liver disease is mostly stable and slowly progressive disease, and it won't cross into cirrhosis that easily. NAFLD spectrum includes mild steatosis with or without inflammation, non-alcoholic steatohepatitis (NASH) characterised by inflammation and faster progression into fibrosis. Patients with NAFLD are asymptomatic. Complications of disease include portal hypertension, hepatocellular carcinoma, cardiovascular disease and malignancies such as colorectal carcinoma and breast cancer. Non-invasive diagnostic methods with high efficacy are developed and have advantage over biopsy. There is no approved therapy for NAFLD, which is why obesity, insulin resistance, diabetes type 2 and dyslipidaemia are targets in treating NAFLD.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:166892
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-07-01 09:46:36