prikaz prve stranice dokumenta The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway
  Download
PDF 3.72 MB
Scientific paper - Original scientific paper
The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway
Cell Death Discovery, 10 (2024), 1; 98. https://doi.org/10.1038/s41420-024-01872-0
Suman, Iva; Šimić, Lidija; Čanadi Jurešić, Gordana; Buljević, Sunčica; Klepac, Damir; Domitrović, Robert

Cite this document

Suman, I., Šimić, L., Čanadi Jurešić, G., Buljević, S., Klepac, D. & Domitrović, R. (2024). The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway. Cell Death Discovery, 10. (1). doi: 10.1038/s41420-024-01872-0

Suman, Iva, et al. "The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway." Cell Death Discovery, vol. 10, no. 1, 2024. https://doi.org/10.1038/s41420-024-01872-0

Suman, Iva, Lidija Šimić, Gordana Čanadi Jurešić, Sunčica Buljević, Damir Klepac and Robert Domitrović. "The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway." Cell Death Discovery 10, no. 1 (2024). https://doi.org/10.1038/s41420-024-01872-0

Suman, I., et al. (2024) 'The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway', Cell Death Discovery, 10(1). doi: 10.1038/s41420-024-01872-0

Suman I, Šimić L, Čanadi Jurešić G, Buljević S, Klepac D, Domitrović R. The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway. Cell Death Discovery [Internet]. 2024 February 24 [cited 2024 December 22];10(1). doi: 10.1038/s41420-024-01872-0

I. Suman, L. Šimić, G. Čanadi Jurešić, S. Buljević, D. Klepac and R. Domitrović, "The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway", Cell Death Discovery, vol. 10, no. 1, February 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:490711. [Accessed: 22 December 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway
AuthorIva Suman
AuthorLidija Šimić
AuthorGordana Čanadi Jurešić
AuthorSunčica Buljević
AuthorDamir Klepac
AuthorRobert Domitrović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Medical Biochemistry
Abstract (english)
AKI induced by CP chemotherapy remains an obstacle during patient treatments. Extracellular signal-regulated protein kinases 1/2 (ERK), key participants in CP-induced nephrotoxicity, are suggested to be involved in the regulation of mitophagy, autophagy, and apoptosis. Human renal proximal tubular cells (HK-2) and BALB/cN mice were used to determine the role of ERK in CP-induced AKI. We found that active ERK is involved in cell viability reduction during apoptotic events but exerts a protective role in the early stages of treatment. Activation of ERK acts as a maintainer of the mitochondrial population and is implicated in mitophagy initiation but has no significant role in its conduction. In the late stages of CP treatment when ATP is deprived, general autophagy that requires ERK activation is initiated as a response, in addition to apoptosis activation. Furthermore, activation of ERK is responsible for the decrease in reserve respiratory capacity and controls glycolysis regulation during CP treatment. Additionally, we found that ERK activation is also required for the induction of NOXA gene and protein expression as well as FoxO3a nuclear translocation, but not for the regular ERK-induced phosphorylation of FoxO3a on Ser294. In summary, this study gives detailed insight into the involvement of ERK activation and its impact on key cellular processes at different time points during CP-induced kidney injury. Inhibitors of ERK activation, including Mirdametinib, are important in the development of new therapeutic strategies for the treatment of AKI in patients receiving CP chemotherapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCell Death Discovery
Numberingvol. 10, no. 1, 98
e-ISSN2058-7716
DOIhttps://doi.org/10.1038/s41420-024-01872-0
URN:NBNurn:nbn:hr:184:490711
Publication2024-02-24
ProjectNumber: uniri-mladi-biomed-20-17
Title (croatian): Modulacija MEK-ERK MAPK signalnog puta u CP-induciranoj mitofagiji u bubrezima
Title (english): Modulation of MEK-ERK MAPK signalling pathway in CP-induced mitophagy in kidneys
Leader: Iva Potočnjak
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
ProjectNumber: uniri-biomed-18-30
Title (croatian): Interakcija lijekova i fitokemikalija in vitro i in vivo: uloga FOXO signalnog puta
Title (english): Interaction between drugs and phytochemicals: the role of FOXO signaling pathway
Leader: Robert Domitrović
Jurisdiction: Croatia
Funding stream: Nema
ProjectNumber: uniri-prirod-18-299
Title (croatian): Sinteza i karakterizacija pametnih polimernih nanočestica s nitroksidnim radikalima
Title (english): Synthesis and characterization of smart polymer nanoparticles with nitroxide radicals
Leader: Damir Klepac
Jurisdiction: Croatia
Funding stream: Nema
Document URLhttps://www.nature.com/articles/s41420-024-01872-0
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-02-28 08:15:52