master's thesis
Utjecaj BCG cjepiva na rezultate tuberkulinskog kožnog testiranja

Milana Đorđevski (2015)
Sveučilište u Rijeci
Medicinski fakultet
Katedra za pedijatriju
Metadata
TitleUtjecaj BCG cjepiva na rezultate tuberkulinskog kožnog testiranja
AuthorMilana Đorđevski
Mentor(s)Srđan Banac (thesis advisor)
Abstract
Tuberkuloza i danas predstavlja veliki javnozdravstveni problem usprkos učinkovitoj terapiji i dobrim programima za eradikaciju. Cilj ovog istraživanja je bilo otkriti utječe li BCG cjepivo na rezultate tuberkulinskog kožnog testiranja, koje su razlike veličini indurata promatranih skupina te koje od primljenih cjepiva daje najveći učinak. U ispitivanju su bila uključena djeca koja su u godinama 2009/2010. i 2010/2011. bila u 7. razredu OŠ. Njihove PPD reakcije su bile ključne u otkrivanju učinaka BCG s obzirom na cjepiva koja su primili kao nereaktori tjekom života ili nisu primili u sklopu Programa obaveznog kalendara cijepljenja. BCG cjepivo je varijabilno utjecalo na TST. Dokazano je da su u necjepljene djece tuberkulinske reakcije neznatno porasle ili da su bile približno slične i malo veće nego u cijepljene djece. Nesoporno je da se jačina PPD reakcije povećavala u starijoj životnoj dobi zbog različitih rizičnih čimbenika u djece, ali i da je daljnje docjepljivanje nereaktora protiv tuberkuloze utjecalo na neznatni porast veličina PPD testiranja i tako otežao dijagnosticiranje LTBI. Preporuka bi daljnja bila da djeca prime cjepivo samo u rodilištu jer tako ostvaruju njegov najveći i nabolji učinak. Treba još puno raditi na otkrivanju idealnijih cjepiva koja neće imati učinak na TST, a pružit će učinkovitu i dugotrajnu zaštitu protiv tuberkuloze.
KeywordsBCG vaccine tuberculin skin testing LTBI
GranterSveučilište u Rijeci
Medicinski fakultet
Lower level organizational unitsKatedra za pedijatriju
PlaceRijeka
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmeMedicine
Academic title abbreviationdr. med.
Genremaster's thesis
Language Croatian
Defense date2015
Parallel abstract (English)
Tuberculosis still a major public health problem despite effective therapy and good eradiction programs are availabile. The aim of this study was to reveal the influence of the BCG vaccine on TST results, to see the size of PPD induration is effected by BCG and which of the received vaccines gives the greatest effect. The study included children who were in the years 2009/2010. and 2010/2011. in the 7th grade elementary school. Their PPD reactions were the key to the discovery of BCG effects, vaccines that they have received as nonreactors or not received within the official immunization schedule during lifetime. BCG vaccine has a variable effect on TST. It has been shown that in non-vaccinated children tuberculin reactions slightly increase or they were approximately similar and slightly higher than in the vaccinated children. The intensitiy of PPD reactions increased during the years because of the different risk factors in children, but further booster vaccination of nonreactors against tuberculosis had effects in increasing the size of the PPD reaction and thus masquerading LTBI. The most largest and excellent results in effectivness are in children who recived the vaccine is in the earliest age.We need to invest a lot of effort on discovering evan better vaccines that will have no effect on TST but will provide an effective and longlasting protection against TB.
Parallel keywords (Croatian)BCG cjepivo tuberkulinsko kožno testiranje LTBI
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:178946
CommitterBosa Licul