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Professional paper - Review paper
LIPIDNA PEROKSIDACIJA - UZROCI I POSLJEDICE
Medicina Fluminensis : Medicina Fluminensis, 43. (2007), 2.; 84-93. urn:nbn:hr:184:513232
Štefan, Leo; Tepšić, Tina; Zavidić, Tina; Urukalo, Marta; Tota, Dalibor; Domitrović, Robert

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Štefan, L., Tepšić, T., Zavidić, T., Urukalo, M., Tota, D. & Domitrović, R. (2007). LIPIDNA PEROKSIDACIJA - UZROCI I POSLJEDICE. Medicina Fluminensis : Medicina Fluminensis, 43.. (2.), 84-93. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:513232

Štefan, Leo, et al. "LIPIDNA PEROKSIDACIJA - UZROCI I POSLJEDICE." Medicina Fluminensis : Medicina Fluminensis, vol. 43., no. 2., 2007, pp. 84-93. https://urn.nsk.hr/urn:nbn:hr:184:513232

Štefan, Leo, Tina Tepšić, Tina Zavidić, Marta Urukalo, Dalibor Tota and Robert Domitrović. "LIPIDNA PEROKSIDACIJA - UZROCI I POSLJEDICE." Medicina Fluminensis : Medicina Fluminensis 43., no. 2. (2007): 84-93. https://urn.nsk.hr/urn:nbn:hr:184:513232

Štefan, L., et al. (2007) 'LIPIDNA PEROKSIDACIJA - UZROCI I POSLJEDICE', Medicina Fluminensis : Medicina Fluminensis, 43.(2.), pp. 84-93. Available at: https://urn.nsk.hr/urn:nbn:hr:184:513232 (Accessed 31 December 2024)

Štefan L, Tepšić T, Zavidić T, Urukalo M, Tota D, Domitrović R. LIPIDNA PEROKSIDACIJA - UZROCI I POSLJEDICE. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2007 June 25 [cited 2024 December 31];43.(2.):84-93. Available at: https://urn.nsk.hr/urn:nbn:hr:184:513232

L. Štefan, T. Tepšić, T. Zavidić, M. Urukalo, D. Tota and R. Domitrović, "LIPIDNA PEROKSIDACIJA - UZROCI I POSLJEDICE", Medicina Fluminensis : Medicina Fluminensis, vol. 43., no. 2., pp. 84-93, June 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:513232. [Accessed: 31 December 2024]

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Metadata
Title (croatian)LIPIDNA PEROKSIDACIJA - UZROCI I POSLJEDICE
Title (english)LIPID PEROXIDATION - CAUSES AND CONSEQUENCES
AuthorLeo Štefan
AuthorTina Tepšić
AuthorTina Zavidić
AuthorMarta Urukalo
AuthorDalibor Tota
AuthorRobert Domitrović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Medical Biochemistry
Abstract (croatian)
SAŽETAK U normalnim biološkim uvjetima, molekula kisika neenzimatskom oksidacijom povremeno oduzima elektrone drugim molekulama, što uzrokuje nastanak slobodnih radikala. Višestruko nezasićene masne kiseline (PUFA) često su meta stvorenih slobodnih radikala, što posljeduje lipidnom peroksidacijom. Unutarstanični i izvanstanični antioksidansi uklanjanjem reaktivnih spojeva kisika i dušika smanjuju mogućnost oksidacijskoga oštećenja lipidnih molekula, u prvom redu PUFA-e, ali i drugih spojeva. Enzimska kataliza jest najučinkovitiji postupak uklanjanja reaktivnih kisikovih vrsta (ROS). U organizmu postoji nekoliko skupina antioksidacijskih enzima uključujući superoksid dismutazu (SOD) za uklanjanje superoksidnoga radikala i katalaza (CAT), te glutation peroksidazu (GPx) za uklanjanje vodikova peroksida i organskih peroksida. Oštećenje lipida može se odrediti mjerenjem količine malondialdehida (MDA), 4-hidroksinonenala (HNE), izoprostana, te drugih produkata lipidne peroksidacije. Povećana lipidna peroksidacija povećava rizik za razvoj ateroskleroze i drugih upalnih bolesti.
Abstract (english)
ABSTRACT Occasionally, under normal biological conditions, oxygen does manage to steal away electrons from other molecules by nonenzymatic autoxidations, which results in the free radical formation. Polyunsaturated fatty acids frequently serves as the target for generated free radicals, inducing lipid peroxidation. Intracellular and extracelular antioxidants attenuate oxidative damage of lipid molecules, primarily PUFA, but also other molecules. The most efficient way to eliminate undesirable toxic species is by means of enzyme catalysis. Families of antioxidant enzymes have evolved for this purpose, including superoxide dismutases (SOD) for the elimination of the superoxide radical, and catalases (CAT) and glutathione peroxidases (GPx) for the elimination of hydrogen peroxide and organic peroxides. Lipid damage could be determined by measuring the amount of malondialdehyde (MDA), 4-hydroxynonenal (HNE), isoprostanes and other products of lipid peroksidation. Increased lipid peroxidation increase the risk of atherogenesis and other inflammatory diseases.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 43., no. 2., pp. 84-93
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:513232
Publication2007-06-25
Document URLhttp://hrcak.srce.hr/22556
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-04-27 16:04:57