prikaz prve stranice dokumenta Early Changes in Frequency of Peripheral Blood Lymphocyte Subpopulations in Severe Traumatic Brain‐Injured Patients
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Scientific paper - Original scientific paper
Early Changes in Frequency of Peripheral Blood Lymphocyte Subpopulations in Severe Traumatic Brain‐Injured Patients
Scandinavian Journal of Immunology, 72 (2010), 1; 57-65. https://doi.org/10.1111/j.1365-3083.2010.02407.x
Mrakovčić‐Šutić, Ines; Sotošek Tokmadžić, Vlatka; Laškarin, Gordana; Mahmutefendic, Hana; Lučin, Pero; Župan, Željko; Šustić, Alan

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Mrakovčić‐Šutić, I., Sotošek Tokmadžić, V., Laškarin, G., Mahmutefendic, H., Lučin, P., Župan, Ž. & Šustić, A. (2010). Early Changes in Frequency of Peripheral Blood Lymphocyte Subpopulations in Severe Traumatic Brain‐Injured Patients. Scandinavian Journal of Immunology, 72. (1), 57-65. doi: 10.1111/j.1365-3083.2010.02407.x

Mrakovčić‐Šutić, Ines, et al. "Early Changes in Frequency of Peripheral Blood Lymphocyte Subpopulations in Severe Traumatic Brain‐Injured Patients." Scandinavian Journal of Immunology, vol. 72, no. 1, 2010, pp. 57-65. https://doi.org/10.1111/j.1365-3083.2010.02407.x

Mrakovčić‐Šutić, Ines, Vlatka Sotošek Tokmadžić, Gordana Laškarin, Hana Mahmutefendic, Pero Lučin, Željko Župan and Alan Šustić. "Early Changes in Frequency of Peripheral Blood Lymphocyte Subpopulations in Severe Traumatic Brain‐Injured Patients." Scandinavian Journal of Immunology 72, no. 1 (2010): 57-65. https://doi.org/10.1111/j.1365-3083.2010.02407.x

Mrakovčić‐Šutić, I., et al. (2010) 'Early Changes in Frequency of Peripheral Blood Lymphocyte Subpopulations in Severe Traumatic Brain‐Injured Patients', Scandinavian Journal of Immunology, 72(1), pp. 57-65. doi: 10.1111/j.1365-3083.2010.02407.x

Mrakovčić‐Šutić I, Sotošek Tokmadžić V, Laškarin G, Mahmutefendic H, Lučin P, Župan Ž, and sur.. Early Changes in Frequency of Peripheral Blood Lymphocyte Subpopulations in Severe Traumatic Brain‐Injured Patients. Scandinavian Journal of Immunology [Internet]. 2010 June 08 [cited 2025 April 15];72(1):57-65. doi: 10.1111/j.1365-3083.2010.02407.x

I. Mrakovčić‐Šutić, et al., "Early Changes in Frequency of Peripheral Blood Lymphocyte Subpopulations in Severe Traumatic Brain‐Injured Patients", Scandinavian Journal of Immunology, vol. 72, no. 1, pp. 57-65, June 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:399933. [Accessed: 15 April 2025]

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Metadata
Title (english)Early Changes in Frequency of Peripheral Blood Lymphocyte Subpopulations in Severe Traumatic Brain‐Injured Patients
AuthorInes Mrakovčić‐Šutić
AuthorVlatka Sotošek Tokmadžić
AuthorGordana Laškarin
AuthorHana Mahmutefendic
AuthorPero Lučin
AuthorŽeljko Župan
AuthorAlan Šustić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Intensive Care
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Abstract (english)
Abstract Infections are leading causes of increased morbidity and mortality of severe traumatic brain‐injured (STBI) patients. The mechanism underlying the susceptibility to the infections is still unexplained. The purpose of the study was to investigate changes in frequency of leucocytes subpopulations in peripheral blood of patients with STBI during the course of intensive care treatment. Twenty patients with STBI were included in the study. Healthy age‐ and sex‐... More volunteers served as control. Peripheral blood samples were taken from these patients at day 1, 4 and 7, and peripheral blood mononuclear cells (PBMC) were isolated. The percentage of T, B lymphocyte, NK and NKT cells as well as monocytes was analysed by simultaneous detection of surface antigens using fluorochrome‐conjugated monoclonal antibodies. The two major subsets of T lymphocytes (CD3 CD56 CD4 and CD3 CD56 CD8 ) and NK cells (CD3 CD56 and CD3 CD56 ) were also analysed by flow cytometry. Extracranial infections were presented in 55% patients with STBI. At day 4, the percentage of T lymphocytes with cytotoxic phenotype significantly diminished and their numbers restored at day 7. The frequency of NKT cells showed the identical time‐dependent pattern, whereas the percentage of NK cells diminished on day 4 but did not restore after 7 days. The frequency of B lymphocytes did not change significantly during the time investigated, whereas the percentage of monocytes increased immediately after the injury and gradually diminished. The decrease in cells with cytotoxic phenotype might explain high incidence of susceptibility to infection of patients with STBI. Less
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleScandinavian Journal of Immunology
Numberingvol. 72, no. 1, pp. 57-65
p-ISSN0300-9475
e-ISSN1365-3083
DOIhttps://doi.org/10.1111/j.1365-3083.2010.02407.x
URN:NBNurn:nbn:hr:184:399933
Publication2010-06-08
ProjectNumber: 062-0000000-0220
Title (croatian): Perkutana traheostomija u prevenciji pneumonije u strojno ventiliranih bolesnika
Title (english): Percutaneous tracheostomy in prevention of ventilator-associated pneumonia
Leader: Alan Šustić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2010.02407.x
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2023-11-02 12:42:49
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