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Scientific paper - Review paper
Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders
Biomedicines, 11 (2023), 10; 2793. https://doi.org/10.3390/biomedicines11102793
De Marchi, Fabiola; Munitić, Ivana; Vidatić, Lea; Papić, Eliša; Rački, Valentino; Nimac, Jerneja; Jurak, Igor; Novotni, Gabriela; Rogelj, Boris; Vuletić, Vladimira; Lisčić, Rajka M.; Cannon, Jason R.; Buratti, Emanuele; Mazzini, Letizia; Hećimović, Silva More authors...

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De Marchi, F., Munitić, I., Vidatić, L., Papić, E., Rački, V., Nimac, J. ... Hećimović, S. (2023). Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders. Biomedicines, 11. (10). doi: 10.3390/biomedicines11102793

De Marchi, Fabiola, et al. "Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders." Biomedicines, vol. 11, no. 10, 2023. https://doi.org/10.3390/biomedicines11102793

De Marchi, Fabiola, Ivana Munitić, Lea Vidatić, Eliša Papić, Valentino Rački, Jerneja Nimac, Igor Jurak, et al. "Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders." Biomedicines 11, no. 10 (2023). https://doi.org/10.3390/biomedicines11102793

De Marchi, F., et al. (2023) 'Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders', Biomedicines, 11(10). doi: 10.3390/biomedicines11102793

De Marchi F, Munitić I, Vidatić L, Papić E, Rački V, Nimac J, and sur.. Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders. Biomedicines [Internet]. 2023 October 14 [cited 2024 November 12];11(10). doi: 10.3390/biomedicines11102793

F. De Marchi, et al., "Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders", Biomedicines, vol. 11, no. 10, October 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:744547. [Accessed: 12 November 2024]

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Metadata
Title (english)Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders
AuthorFabiola De Marchi
AuthorIvana Munitić
AuthorLea Vidatić
AuthorEliša Papić
AuthorValentino Rački
AuthorJerneja Nimac
AuthorIgor Jurak
AuthorGabriela Novotni
AuthorBoris Rogelj
AuthorVladimira Vuletić
AuthorRajka M. Lisčić
AuthorJason R. Cannon
AuthorEmanuele Buratti
AuthorLetizia Mazzini
AuthorSilva Hećimović
Author's institution(Clinical Hospital Center Rijeka)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Many potential immune therapeutic targets are similarly affected in adult-onset neurodegenerative diseases, such as Alzheimer’s (AD) disease, Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD), as well as in a seemingly distinct Niemann–Pick type C disease with primarily juvenile onset. This strongly argues for an overlap in pathogenic mechanisms. The commonly researched immune targets include various immune cell subsets, such as microglia, peripheral macrophages, and regulatory T cells (Tregs); the complement system; and other soluble factors. In this review, we compare these neurodegenerative diseases from a clinical point of view and highlight common pathways and mechanisms of protein aggregation, neurodegeneration, and/or neuroinflammation that could potentially lead to shared treatment strategies for overlapping immune dysfunctions in these diseases. These approaches include but are not limited to immunisation, complement cascade blockade, microbiome regulation, inhibition of signal transduction, Treg boosting, and stem cell transplantation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 11, no. 10, 2793
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines11102793
URN:NBNurn:nbn:hr:184:744547
Publication2023-10-14
Document URLhttps://www.mdpi.com/2227-9059/11/10/2793
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-10-18 10:03:49