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Globalno širenje bakterija koje proizvode karbapenemaze
Medicina Fluminensis : Medicina Fluminensis, 50 (2014), 2; 128-149. urn:nbn:hr:184:520953
Bubonja-Šonje, Marina; Abram, Maja

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Bubonja Šonje, M. & Abram, M. (2014). Globalno širenje bakterija koje proizvode karbapenemaze. Medicina Fluminensis : Medicina Fluminensis, 50. (2), 128-149. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:520953

Bubonja Šonje, Marina and Maja Abram. "Globalno širenje bakterija koje proizvode karbapenemaze." Medicina Fluminensis : Medicina Fluminensis, vol. 50, no. 2, 2014, pp. 128-149. https://urn.nsk.hr/urn:nbn:hr:184:520953

Bubonja Šonje, Marina and Maja Abram. "Globalno širenje bakterija koje proizvode karbapenemaze." Medicina Fluminensis : Medicina Fluminensis 50, no. 2 (2014): 128-149. https://urn.nsk.hr/urn:nbn:hr:184:520953

Bubonja Šonje, M. and Abram, M. (2014) 'Globalno širenje bakterija koje proizvode karbapenemaze', Medicina Fluminensis : Medicina Fluminensis, 50(2), pp. 128-149. Available at: https://urn.nsk.hr/urn:nbn:hr:184:520953 (Accessed 27 April 2024)

Bubonja Šonje M, Abram M. Globalno širenje bakterija koje proizvode karbapenemaze. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2014 June 02 [cited 2024 April 27];50(2):128-149. Available at: https://urn.nsk.hr/urn:nbn:hr:184:520953

M. Bubonja Šonje and M. Abram, "Globalno širenje bakterija koje proizvode karbapenemaze", Medicina Fluminensis : Medicina Fluminensis, vol. 50, no. 2, pp. 128-149, June 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:520953. [Accessed: 27 April 2024]

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Metadata
Title (croatian)Globalno širenje bakterija koje proizvode karbapenemaze
Title (english)Global spread of carbapenemase-producing bacteria
AuthorMarina Bubonja-Šonje
AuthorMaja Abram
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (croatian)
Klinički značaj enzima karbapenemaza očituje se u njihovoj sposobnosti hidrolize karbapenema, zbog čega bakterije koje ih proizvode razvijaju otpornost na ovu podskupinu β-laktamskih antibiotika širokog spektra, kao i na većinu ostalih pripadnika iste skupine (penicilini, cefalosporini). Karbapenemaza producirajući sojevi gram-negativnih bakterija od velikog su epidemiološkog značaja, budući da trend širenja ovih β-laktamaza među bolničkim, ali i izvanbolničkim izolatima postaje ozbiljna globalna prijetnja. Često uzrokuju manje ili veće epidemije u zdravstvenim ustanovama. Geni koji kodiraju karbapenemaze obično se prenose na druge bakterije zajedno s genima koji su odgovorni za rezistenciju na ostale skupine antibiotika, kao što su kinoloni i aminoglikozidi. Među najproširenijim karbapenemazama nalaze se metalo-β-laktamaze IMP, VIM i NDM-tipa, a početkom trećeg milenija postali smo svjedoci globalne krize zbog eksplozivnog širenja višestruko otporne Klebsiella pneumoniae koja proizvodi KPC β-laktamazu. Zabrinjava činjenica da pojava i širenje enterobakterija, pseudomonasa i acinetobaktera otpornih na karbapeneme značajno pridonosi povećanom pobolu i smrtnosti pacijenata. Za probir karbapenemaza producirajućih sojeva u mikrobiološkom laboratoriju koriste se klasične fenotipske metode zasnovane na kultivaciji, nakon čega je neophodno potvrditi produkciju enzima primjenom potvrdnih (fenotipskih i/ili molekularnih) metoda. Identifikacija specifičnih gena koji kodiraju enzime temelji se na molekularnim tehnikama. Dijagnostiku i interpretaciju dobivenih laboratorijskih rezultata otežava neprepoznavanje rezistencije nižeg stupnja koja se može javiti u određenom postotku karbapenemaza producirajućih sojeva. Zbog vrlo ograničenog izbora djelotvornih antibiotika vrlo je značajno rano otkrivanje producirajućih sojeva te sprječavanje njihova prijenosa. Pravovremeno otkrivanje inficiranih pacijenata, ali i zdravih kliconoša ključan je korak u prevenciji širenja rezistentnih sojeva bakterija.
Abstract (english)
Carbapenemases are clinically important enzymes because they hydrolyse and inactivate the broad-spectrum β-lactam antibiotics carbapenems. Carbapenemase-producing strains are resistant to carbapenems and to most of the other classes of β-lactams (penicillins, cephalosporins). The growing trend of the carbapenemase-producing strains between inpatient and outpatient isolates of gram-negative bacteria is becoming a global health threat. Infections caused by carbapenemase-producing strains often occur as outbreaks. In addition, carbapenemase- encoding genes are frequently transferred to other bacteria along with the genes responsible for resistance to other classes of antibiotics, such as quinolones and aminoglycosides. The most widespread carbapenemases are metallo-β-lactamase IMP, VIM and NDM-types. At the beginning of the third millennium we witnessed the global spread of KPC-producing, multidrugresistant Klebsiella pneumoniae. The emergence and spread of carbapenem-resistant Enterobacteriaceae, Pseudomonas and Acinetobacter strains leads to an increase in morbidity and mortality rates. Phenotypic methods based on cultivation are used for screening of carbapenemase- producing strains, however, enzyme production must be confirmed by phenotypic or molecular methods. Identification of specific carbapenemase-encoding genes is mainly based on molecular techniques. Low level resistance that can occur in a certain percentage of carbapenemase-producing strains complicates detection and laboratory tests interpretation. Due to the very limited choice of effective antibiotics early detection of carbapenemase-producing strains becomes of paramount importance. Strict infection control measures, including active surveillance for timely detection of colonised patients and prompt isolation of carriers are key steps for preventing the transmission of these bacteria in healthcare settings.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 50, no. 2, pp. 128-149
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:520953
Publication2014-06-02
Document URLhttp://hrcak.srce.hr/121848
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-04-26 11:20:41