prikaz prve stranice dokumenta The Role of PrPC in the Course of CMV Infection
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master's thesis
The Role of PrPC in the Course of CMV Infection
graduation thesis
2023. urn:nbn:hr:184:624209
Herrlich, Benjamin
University of Rijeka
Faculty of Medicine

Cite this document

Herrlich, B. (2023). The Role of PrPC in the Course of CMV Infection : graduation thesis (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:624209

Herrlich, Benjamin. "The Role of PrPC in the Course of CMV Infection : graduation thesis." Master's thesis, University of Rijeka, Faculty of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:184:624209

Herrlich, Benjamin. "The Role of PrPC in the Course of CMV Infection : graduation thesis." Master's thesis, University of Rijeka, Faculty of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:184:624209

Herrlich, B. (2023). 'The Role of PrPC in the Course of CMV Infection : graduation thesis', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 13 May 2024, https://urn.nsk.hr/urn:nbn:hr:184:624209

Herrlich B. The Role of PrPC in the Course of CMV Infection : graduation thesis [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2023 [cited 2024 May 13] Available at: https://urn.nsk.hr/urn:nbn:hr:184:624209

B. Herrlich, "The Role of PrPC in the Course of CMV Infection : graduation thesis", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:184:624209

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Metadata
TitleThe Role of PrPC in the Course of CMV Infection : graduation thesis
AuthorBenjamin Herrlich
MentorTihana Lenac Roviš (mentor)
Committee memberGordana Blagojević Zagorac (predsjednik povjerenstva)
Committee memberAstrid Krmpotić (član povjerenstva)
Committee memberStipan Jonjić (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
Rijeka
Defense date and country2023-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Abstract
This thesis investigates the influence of PrPC on the immune response against MCMV in lung tissue. Histological investigations support the preliminary claim that the absence of PrPC influences viral clearance in multiple tissues such as in the liver leading to less recorded tissue insult. Further, viral titration of lung tissue demonstrated no significant difference between wild type mice and those lacking PrPC . Searching for an explanation for this finding, we analyzed differences in cytokine levels in the brain and lungs. We found IL-17A levels to behave differently in the lungs compared to brain tissue. Only in the lungs did we record a significant increase of IL-17A levels in PrPC KO mice following infection while in brain tissue a comparable finding was absent. Concisely, our findings indicate the MCMV inflicted immune response to be differently affected by the absence of PrPC in comparison to other tissues and the expression of IL-17A to be unrelated to PrPC .
Keywords
Languageenglish
URN:NBNurn:nbn:hr:184:624209
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2023-07-14
Terms of useLicence In copyright icon
Created on2023-07-11 08:53:41