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master's thesis
Farmakokinetika i farmakodinamika intravenskih anestetika u djece
2023. urn:nbn:hr:184:131440
Vidović, Ines
University of Rijeka
Faculty of Medicine

Cite this document

Vidović, I. (2023). Farmakokinetika i farmakodinamika intravenskih anestetika u djece (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:131440

Vidović, Ines. "Farmakokinetika i farmakodinamika intravenskih anestetika u djece." Master's thesis, University of Rijeka, Faculty of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:184:131440

Vidović, Ines. "Farmakokinetika i farmakodinamika intravenskih anestetika u djece." Master's thesis, University of Rijeka, Faculty of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:184:131440

Vidović, I. (2023). 'Farmakokinetika i farmakodinamika intravenskih anestetika u djece', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 03 January 2025, https://urn.nsk.hr/urn:nbn:hr:184:131440

Vidović I. Farmakokinetika i farmakodinamika intravenskih anestetika u djece [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2023 [cited 2025 January 03] Available at: https://urn.nsk.hr/urn:nbn:hr:184:131440

I. Vidović, "Farmakokinetika i farmakodinamika intravenskih anestetika u djece", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:184:131440

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Metadata
TitleFarmakokinetika i farmakodinamika intravenskih anestetika u djece
Title (english)Pharmacokinetics and Pharmacodynamics of Intravenous Anesthetics in Children
AuthorInes Vidović
MentorVlatka Sotošek Tokmadžić (mentor)
Committee memberAlan Šustić (predsjednik povjerenstva)
Committee memberJanja Tarčuković (član povjerenstva)
Committee memberKristina Pilipović (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
Rijeka
Defense date and country2023-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract
U pedijatrijskoj populaciji prisutne su mnoge fiziološke specifičnosti u odnosu na odraslu populaciju koje utječu na farmakokinetiku i farmakodinamiku lijekova, uključujući i intravenske anestetike. Najvažniji čimbenici koji utječu na farmakokinetiku lijekova u novorođenčadi su: veći volumen distribucije, smanjeno vezivanje za proteine plazme, smanjene zalihe masti te nezrela bubrežna i jetrena funkcija. S rastom i razvojem djeteta farmakokinetski parametri uglavnom se postepeno približavaju vrijednostima odraslih. Također, dolazi i do sazrijevanja farmakodinamskih čimbenika poput zrelosti ciljnog receptora, mehanizama prijenosa signala s receptora na druge glasnike i sposobnosti tkiva ili organa da odgovori na signal. Doziranje lijekova u pedijatriji može se izračunati pomoću jednostavnih formula, alometrijskih izračuna te pomoću različitih farmakokinetskih i farmakodinamskih modela. Za svaki intravenski anestetik postoje određene specifičnosti u farmakokinetici i farmakodinamici koje su ovisne o dobi djeteta i potrebno je detaljno znanje iz područja pedijatrije, fiziologije i farmakologije kako bismo postigli željeni učinak intravenskog anestetika, a izbjegli neželjene učinke.
Abstract (english)
In the pediatric population, there are many physiological differences compared to adults that influence the pharmacokinetics and pharmacodynamics of drugs, including intravenous anesthetics. The most important factors which affect drug pharmacokinetics in newborns are: larger volume of distribution, reduced plasma protein binding, decreased fat stores, and immature renal and hepatic function. Generally, following the child’s growth and development, pediatric pharmacokinetic parameters gradually begin to approach adult values. Pharmacodynamic factors, such as: receptor maturity, signal transduction mechanisms from the receptors to the second messengers, and tissue or organ response to signals, also show developmental changes. Dosage calculations in pediatrics can be done using simple formulas and allometric calculations, as well as various pharmacokinetic and pharmacodynamic models. Each intravenous anesthetic has its specific pharmacokinetic and pharmacodynamic characteristics dependent on the child's age, and it is necessary to have extensive knowledge of pediatrics, physiology, and pharmacology in order to achieve the desired effect of the intravenous anesthetic while avoiding adverse effects.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:131440
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-06-21 16:13:19