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Scientific paper - Original scientific paper
Diagnostic Three Slides Pap Test Compared to Punch Biopsy and Endocervical Curettage in Confirmed HSIL+ Diagnosis
Diagnostics, 11 (2021), 6; 1-9. https://doi.org/10.3390/diagnostics11060942
Rubeša-Mihaljević, Roberta; Vrdoljak-Mozetič, Danijela; Dinter, Morana; Verša Ostojić, Damjana; Štemberger-Papić, Snježana; Klarić, Marko

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Rubeša Mihaljević, R., Vrdoljak Mozetič, D., Dinter, M., Verša Ostojić, D., Štemberger Papić, S. & Klarić, M. (2021). Diagnostic Three Slides Pap Test Compared to Punch Biopsy and Endocervical Curettage in Confirmed HSIL+ Diagnosis. Diagnostics, 11. (6), 1-9. doi: 10.3390/diagnostics11060942

Rubeša Mihaljević, Roberta, et al. "Diagnostic Three Slides Pap Test Compared to Punch Biopsy and Endocervical Curettage in Confirmed HSIL+ Diagnosis." Diagnostics, vol. 11, no. 6, 2021, pp. 1-9. https://doi.org/10.3390/diagnostics11060942

Rubeša Mihaljević, Roberta, Danijela Vrdoljak Mozetič, Morana Dinter, Damjana Verša Ostojić, Snježana Štemberger Papić and Marko Klarić. "Diagnostic Three Slides Pap Test Compared to Punch Biopsy and Endocervical Curettage in Confirmed HSIL+ Diagnosis." Diagnostics 11, no. 6 (2021): 1-9. https://doi.org/10.3390/diagnostics11060942

Rubeša Mihaljević, R., et al. (2021) 'Diagnostic Three Slides Pap Test Compared to Punch Biopsy and Endocervical Curettage in Confirmed HSIL+ Diagnosis', Diagnostics, 11(6), pp. 1-9. doi: 10.3390/diagnostics11060942

Rubeša Mihaljević R, Vrdoljak Mozetič D, Dinter M, Verša Ostojić D, Štemberger Papić S, Klarić M. Diagnostic Three Slides Pap Test Compared to Punch Biopsy and Endocervical Curettage in Confirmed HSIL+ Diagnosis. Diagnostics [Internet]. 2021 [cited 2025 April 25];11(6):1-9. doi: 10.3390/diagnostics11060942

R. Rubeša Mihaljević, D. Vrdoljak Mozetič, M. Dinter, D. Verša Ostojić, S. Štemberger Papić and M. Klarić, "Diagnostic Three Slides Pap Test Compared to Punch Biopsy and Endocervical Curettage in Confirmed HSIL+ Diagnosis", Diagnostics, vol. 11, no. 6, pp. 1-9, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:460244. [Accessed: 25 April 2025]

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Title (english)Diagnostic Three Slides Pap Test Compared to Punch Biopsy and Endocervical Curettage in Confirmed HSIL+ Diagnosis
AuthorRoberta Rubeša-Mihaljević
AuthorDanijela Vrdoljak-Mozetič
AuthorMorana Dinter
AuthorDamjana Verša Ostojić
AuthorSnježana Štemberger-Papić
AuthorMarko Klarić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Objective: The aim of the study was to evaluate the accuracy of the diagnostic Pap test (DPT) on three slides and punch biopsy and endocervical curettage (PB/ECC) compared with the final biopsy material in the detection of high-grade squamous intraepithelial lesion (HSIL). Materials and methods: Patients treated with conization after previous DPT and PB/ECC were analyzed. The findings of the DPT and PB/ECC as well as of the endocervical brush cytology and ECC were compared with the final conus histology. Results: 150 patients were analyzed, and final histology verified 145 cases of HSIL and 3 cancers. The percentage of confirmed HSIL cytology was 97%, while for PB/ECC it was 79% with 30/145 false negative results. The correlation between Pap test and PB/ECC showed that the diagnostic accuracy of DPT is significantly higher (p < 0.0001). Endocervical brush cytology confirmed HSIL+ in the endocervical canal in 83% and ECC in 35% of cases (p < 0.0001). Conclusion: The DPT on three slides enables better detection of HSIL compared to PB/ECC, particularly for lesions localized in the endocervical canal sampled with a cytobrush. A high quality DPT could represent a surrogate for PB/ECC and open the possibility of direct access to therapeutic procedure
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDiagnostics
Numberingvol. 11, no. 6, pp. 1-9
p-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics11060942
URN:NBNurn:nbn:hr:184:460244
Publication2021
Document URLhttp://bib.irb.hr/1251725
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-02-06 08:19:13