prikaz prve stranice dokumenta Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions
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Scientific paper - Original scientific paper
Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions
Current Microbiology, 78 (2021); 1188-1201. https://doi.org/10.1007/s00284-021-02390-3
Čanadi Jurešić, Gordana; Ćurko-Cofek, Božena; Barbarić, Martina; Mumiši, Nermina; Blagović, Branka; Jamnik, Polona

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Čanadi Jurešić, G., Ćurko Cofek, B., Barbarić, M., Mumiši, N., Blagović, B. & Jamnik, P. (2021). Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions. Current Microbiology, 78., 1188-1201. doi: 10.1007/s00284-021-02390-3

Čanadi Jurešić, Gordana, et al. "Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions." Current Microbiology, vol. 78, 2021, pp. 1188-1201. https://doi.org/10.1007/s00284-021-02390-3

Čanadi Jurešić, Gordana, Božena Ćurko Cofek, Martina Barbarić, Nermina Mumiši, Branka Blagović and Polona Jamnik. "Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions." Current Microbiology 78 (2021): 1188-1201. https://doi.org/10.1007/s00284-021-02390-3

Čanadi Jurešić, G., et al. (2021) 'Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions', Current Microbiology, 78, pp. 1188-1201. doi: 10.1007/s00284-021-02390-3

Čanadi Jurešić G, Ćurko Cofek B, Barbarić M, Mumiši N, Blagović B, Jamnik P. Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions. Current Microbiology [Internet]. 2021 [cited 2025 January 03];78:1188-1201. doi: 10.1007/s00284-021-02390-3

G. Čanadi Jurešić, B. Ćurko Cofek, M. Barbarić, N. Mumiši, B. Blagović and P. Jamnik, "Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions", Current Microbiology, vol. 78, pp. 1188-1201, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:467796. [Accessed: 03 January 2025]

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Metadata
Title (english)Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions
AuthorGordana Čanadi Jurešić
AuthorBožena Ćurko-Cofek
AuthorMartina Barbarić
AuthorNermina Mumiši
AuthorBranka Blagović
AuthorPolona Jamnik
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Scientific / art field,
discipline and subdiscipline		INTERDISCIPLINARY AREAS OF KNOWLEDGE
Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Interdisciplinary Technical Sciences
Abstract (english)
Yeast Saccharomyces cerevisiae is an ideal model organism for studying molecular mechanisms of the stress response provoked by metals. In this work, yeast cells response to iron (Fe3+) or lead (Pb2+) exposure was tested and compared. Survival test was used to determine testing doses of metal ions – for Fe3+ it was 4 mM and for Pb2+ 8mM. These (high, over-loaded) doses provoked comparable values of growth inhibition, but different values in vitality measurement. The percentage of metabolically active cells, determined by fluorescent FUN-1 dye, was lower in Pb2+ than in Fe3+ treated cells. Besides, endogenous antioxidant defence systems in the cells treated with Pb2+ were less efficient compared to Fe3+. At the mitochondrial level, the effects of metal ions were in correlation with the results of cell metabolic activity. The mitochondrial proteome of Pb2+ treated cells showed the domination of protein down- regulation. Yeast cells treated either with Fe3+ or Pb2+ shared 19 common significantly changed proteins. The affected proteins were involved in different cellular process and among them only five proteins belong to energy and carbohydrate metabolism, and protein biosynthesis. Based on all obtained results, it is possible to conclude that the effects of Fe3+ and Pb2+ on yeast cells show rather specific patterns of toxicity and stress response.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCurrent Microbiology
Numberingvol. 78, pp. 1188-1201
p-ISSN0343-8651
e-ISSN1432-0991
DOIhttps://doi.org/10.1007/s00284-021-02390-3
URN:NBNurn:nbn:hr:184:467796
Publication2021
Document URLhttp://bib.irb.hr/1104907
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2023-02-02 08:29:21