prikaz prve stranice dokumenta Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report
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Scientific paper - Case study
Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report
Croatian Medical Journal, 62 (2021), 3; 288-296. https://doi.org/10.3325/cmj.2021.62.288
Primorac, Dragan; Stojanović Stipić, Sanda; Strbad, Marko; Girandon, Lenart; Barlič, Ariana; Ivić, Ivo; Marasović Krstulović, Daniela; Jukić, Irena; Halassy, Beata; Hećimović, Ana; Matišić, Vid; Molnar, Vilim

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Primorac, D., Stojanović Stipić, S., Strbad, M., Girandon, L., Barlič, A., Ivić, I. ... Molnar, V. (2021). Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report. Croatian Medical Journal, 62. (3), 288-296. doi: 10.3325/cmj.2021.62.288

Primorac, Dragan, et al. "Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report." Croatian Medical Journal, vol. 62, no. 3, 2021, pp. 288-296. https://doi.org/10.3325/cmj.2021.62.288

Primorac, Dragan, Sanda Stojanović Stipić, Marko Strbad, Lenart Girandon, Ariana Barlič, Ivo Ivić, Daniela Marasović Krstulović, et al. "Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report." Croatian Medical Journal 62, no. 3 (2021): 288-296. https://doi.org/10.3325/cmj.2021.62.288

Primorac, D., et al. (2021) 'Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report', Croatian Medical Journal, 62(3), pp. 288-296. doi: 10.3325/cmj.2021.62.288

Primorac D, Stojanović Stipić S, Strbad M, Girandon L, Barlič A, Ivić I, and sur.. Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report. Croatian Medical Journal [Internet]. 2021 [cited 2024 November 15];62(3):288-296. doi: 10.3325/cmj.2021.62.288

D. Primorac, et al., "Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report", Croatian Medical Journal, vol. 62, no. 3, pp. 288-296, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:969076. [Accessed: 15 November 2024]

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Metadata
Title (english)Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report
AuthorDragan Primorac
AuthorSanda Stojanović Stipić
AuthorMarko Strbad
AuthorLenart Girandon
AuthorAriana Barlič
AuthorIvo Ivić
AuthorDaniela Marasović Krstulović
AuthorIrena Jukić
AuthorBeata Halassy
AuthorAna Hećimović
AuthorVid Matišić
AuthorVilim Molnar
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
COVID-19 presentations range from cold-like symptoms to severe symptoms with the development of acute respiratory distress syndrome (ARDS). We report on a severe COVID-19 patient who was mechanically ventilated and who developed ARDS and bacterial infection. Because of rapid clinical deterioration and the exhaustion of other treatment options, the family and attending physicians requested a compassionate use of adult allogeneic bone marrow-derived mesenchymal stem cells (MSC) in addition to commonly used immunosuppressive, antiviral, and supportive therapy. The clinical course is discussed thoroughly, with a special emphasis on the safety and effect of MSC therapy. Compassionate MSC treatment, given in three rounds, affected ARDS regression. The patient was discharged from the intensive care unit after 31 days and from hospital after 49 days in a good general condition. MSC treatment was not associated with any side effects and was well tolerated in a three-week period; therefore, it should be studied in larger trials and considered for compassionate use
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 62, no. 3, pp. 288-296
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2021.62.288
URN:NBNurn:nbn:hr:184:969076
Publication2021
ProjectNumber: IP-CORONA-2020-04-2053
Title (croatian): Stvaranje preduvjeta za uvođenje SARS-CoV-2 seroterapije u Hrvatskoj
Leader: Beata Halassy
Jurisdiction: Croatia
Funding stream: IP-CORONA
ProjectNumber: KK.011.1.01.0006
Title (croatian): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: eu
ProjectNumber: N/A
Title (croatian): Centar izvrsnosti za virusnu imunologiju i cjepiva
Title (english): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Acronym: CERVirVac
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZCI
Document URLhttps://hrcak.srce.hr/278142
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) icon
Created on2023-02-02 07:47:41