prikaz prve stranice dokumenta Assessment of antinuclear antibodies (ANA): National recommendations on behalf of the Croatian society of medical biochemistry and laboratory medicine
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Scientific paper - Review paper
Assessment of antinuclear antibodies (ANA): National recommendations on behalf of the Croatian society of medical biochemistry and laboratory medicine
Biochemia Medica, 31 (2021), 2; 210-229. https://doi.org/10.11613/BM.2021.020502
Tešija Kuna, Andrea; Đerek, Lovorka; Drvar, Vedrana; Kozmar, Ana; Gugo, Katarina

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Tešija Kuna, A., Đerek, L., Drvar, V., Kozmar, A. & Gugo, K. (2021). Assessment of antinuclear antibodies (ANA): National recommendations on behalf of the Croatian society of medical biochemistry and laboratory medicine. Biochemia Medica, 31. (2), 210-229. doi: 10.11613/BM.2021.020502

Tešija Kuna, Andrea, et al. "Assessment of antinuclear antibodies (ANA): National recommendations on behalf of the Croatian society of medical biochemistry and laboratory medicine." Biochemia Medica, vol. 31, no. 2, 2021, pp. 210-229. https://doi.org/10.11613/BM.2021.020502

Tešija Kuna, Andrea, Lovorka Đerek, Vedrana Drvar, Ana Kozmar and Katarina Gugo. "Assessment of antinuclear antibodies (ANA): National recommendations on behalf of the Croatian society of medical biochemistry and laboratory medicine." Biochemia Medica 31, no. 2 (2021): 210-229. https://doi.org/10.11613/BM.2021.020502

Tešija Kuna, A., et al. (2021) 'Assessment of antinuclear antibodies (ANA): National recommendations on behalf of the Croatian society of medical biochemistry and laboratory medicine', Biochemia Medica, 31(2), pp. 210-229. doi: 10.11613/BM.2021.020502

Tešija Kuna A, Đerek L, Drvar V, Kozmar A, Gugo K. Assessment of antinuclear antibodies (ANA): National recommendations on behalf of the Croatian society of medical biochemistry and laboratory medicine. Biochemia Medica [Internet]. 2021 [cited 2025 February 24];31(2):210-229. doi: 10.11613/BM.2021.020502

A. Tešija Kuna, L. Đerek, V. Drvar, A. Kozmar and K. Gugo, "Assessment of antinuclear antibodies (ANA): National recommendations on behalf of the Croatian society of medical biochemistry and laboratory medicine", Biochemia Medica, vol. 31, no. 2, pp. 210-229, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:063450. [Accessed: 24 February 2025]

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Metadata
Title (english)Assessment of antinuclear antibodies (ANA): National recommendations on behalf of the Croatian society of medical biochemistry and laboratory medicine
AuthorAndrea Tešija Kuna https://orcid.org/0000-0001-6871-2686
AuthorLovorka Đerek https://orcid.org/0000-0002-3041-7718
AuthorVedrana Drvar https://orcid.org/0000-0002-4011-856X
AuthorAna Kozmar
AuthorKatarina Gugo
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Biochemistry
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Medical Biochemistry
Abstract (english)
Antinuclear antibodies (ANA) represent a family of autoantibodies targeting ubiquitous cellular constituents and are a hallmark of systemic inflammatory autoimmune rheumatic diseases named connective tissue diseases (CTD). The gold standard method for ANA determination is indirect immunofluorescence (IIF) on the human laryngeal epidermoid carcinoma cell line type 2 substrate (HEp-2), but with increasing demand for ANA testing, novel methods eased for automation emerged, which allows testing by staff less experienced in this specific field of laboratory diagnostic. In 2016 The working group (WG) for laboratory diagnostics of autoimmune diseases as part of the Committee for the Scientific Professional Development of the Croatian Society of Medical Biochemistry and Laboratory Medicine (CSMBLM) published the data of a survey regarding general practice in laboratory diagnostics of autoimmune diseases in Croatia. Results indicated high diversity in the performance of autoantibody testing as well as reporting of the results and indicated the need of creating recommendations for the assessment of ANA that would help harmonize diagnostics of systemic autoimmune rheumatic diseases in Croatia. This document encompasses twenty-seven recommendations for ANA testing created concerning indications for ANA testing, preanalytical, analytical, and postanalytical issues, including rational algorithm and quality control assurance. These recommendations are based on the relevant international recommendations and guidelines for the assessment of ANA testing and relevant literature search and should help to harmonize the approach in ANA testing and clarify differences in interpretation of the results obtained using different methods of determination.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiochemia Medica
Numberingvol. 31, no. 2, pp. 210-229
p-ISSN1330-0962
e-ISSN1846-7482
DOIhttps://doi.org/10.11613/BM.2021.020502
URN:NBNurn:nbn:hr:184:063450
Publication2021
Document URLhttps://hrcak.srce.hr/258877
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-01-31 09:44:04