prikaz prve stranice dokumenta Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE)
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Scientific paper - Original scientific paper
Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE)
British journal of anaesthesia, 126 (2021), 6; 1157-1172. https://doi.org/10.1016/j.bja.2021.02.016.
Disma, Nicola; Veyckemans, Francis; Virag, Katalin; Butković, Diana; Kerovec Sorić, Ivana; Kralik, Sandra; Markić, Ana; AŽman, Josip; Markić, Joško; Pupačić, Daniela

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Disma, N., Veyckemans, F., Virag, K., Butković, D., Kerovec Sorić, I., Kralik, S. ... Pupačić, D. (2021). Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE). British journal of anaesthesia, 126. (6), 1157-1172. doi: 10.1016/j.bja.2021.02.016.

Disma, Nicola, et al. "Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE)." British journal of anaesthesia, vol. 126, no. 6, 2021, pp. 1157-1172. https://doi.org/10.1016/j.bja.2021.02.016.

Disma, Nicola, Francis Veyckemans, Katalin Virag, Diana Butković, Ivana Kerovec Sorić, Sandra Kralik, Ana Markić, Josip AŽman, Joško Markić and Daniela Pupačić. "Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE)." British journal of anaesthesia 126, no. 6 (2021): 1157-1172. https://doi.org/10.1016/j.bja.2021.02.016.

Disma, N., et al. (2021) 'Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE)', British journal of anaesthesia, 126(6), pp. 1157-1172. doi: 10.1016/j.bja.2021.02.016.

Disma N, Veyckemans F, Virag K, Butković D, Kerovec Sorić I, Kralik S, and sur.. Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE). British journal of anaesthesia [Internet]. 2021 [cited 2024 October 26];126(6):1157-1172. doi: 10.1016/j.bja.2021.02.016.

N. Disma, et al., "Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE)", British journal of anaesthesia, vol. 126, no. 6, pp. 1157-1172, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:232879. [Accessed: 26 October 2024]

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Metadata
Title (english)Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE)
AuthorNicola Disma
AuthorFrancis Veyckemans
AuthorKatalin Virag
AuthorDiana Butković
AuthorIvana Kerovec Sorić
AuthorSandra Kralik
AuthorAna Markić
AuthorJosip AŽman
AuthorJoško Markić
AuthorDaniela Pupačić
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background Neonates and infants requiring anaesthesia are at risk of physiological instability and complications, but triggers for peri- anaesthetic interventions and associations with subsequent outcome are unknown. Methods This prospective, observational study recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. The primary aim was to identify thresholds of pre-determined physiological variables that triggered a medical intervention. The secondary aims were to evaluate morbidities, mortality at 30 and 90 days, or both, and associations with critical events. Results Infants (n=5609) born at mean (standard deviation [sd]) 36.2 (4.4) weeks postmenstrual age (35.7% preterm) underwent 6542 procedures within 63 (48) days of birth. Critical event(s) requiring intervention occurred in 35.2% of cases, mainly hypotension (>30% decrease in blood pressure) or reduced oxygenation (SpO2 <85%). Postmenstrual age influenced the incidence and thresholds for intervention. Risk of critical events was increased by prior neonatal medical conditions, congenital anomalies, or both (relative risk [RR]=1.16 ; 95% confidence interval [CI], 1.04– 1.28) and in those requiring preoperative intensive support (RR=1.27 ; 95% CI, 1.15– 1.41). Additional complications occurred in 16.3% of patients by 30 days, and overall 90- day mortality was 3.2% (95% CI, 2.7–3.7%). Co- occurrence of intraoperative hypotension, hypoxaemia, and anaemia was associated with increased risk of morbidity (RR=3.56 ; 95% CI, 1.64–7.71) and mortality (RR=19.80 ; 95% CI, 5.87–66.7). Conclusions Variability in physiological thresholds that triggered an intervention, and the impact of poor tissue oxygenation on patient's outcome, highlight the need for more standardised perioperative management guidelines for neonates and infants.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBritish journal of anaesthesia
Numberingvol. 126, no. 6, pp. 1157-1172
p-ISSN0007-0912
DOIhttps://doi.org/10.1016/j.bja.2021.02.016.
URN:NBNurn:nbn:hr:184:232879
Publication2021
Document URLhttp://bib.irb.hr/1132179
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2023-01-30 12:36:07