prikaz prve stranice dokumenta Accuracy of Controlled Attenuation Parameter and Liver Stiffness Measurement in Patients with Non-alcoholic Fatty Liver Disease
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Scientific paper - Original scientific paper
Accuracy of Controlled Attenuation Parameter and Liver Stiffness Measurement in Patients with Non-alcoholic Fatty Liver Disease
Ultrasound in Medicine & Biology, 47 (2021), 3; 428-437. https://doi.org/10.1016/j.ultrasmedbio.2020.11.015
Mikolaševic, Ivana; Domislović, Viktor; Klapan, Mia; Jurić, Toni; Lukić, Andjela; Krznarić-Zrnić, Irena; Fučkar Čupić, Dora; Štimac, Davor; Filipec Kanižaj, Tajana; Krznaric, Željko; Radić-Krišto, Delfa; Milić, Sandra; Martinović, Marko; Grubešić, Aron; Grgurević, Ivica More authors...

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Mikolaševic, I., Domislović, V., Klapan, M., Jurić, T., Lukić, A., Krznarić Zrnić, I. ... Grgurević, I. (2021). Accuracy of Controlled Attenuation Parameter and Liver Stiffness Measurement in Patients with Non-alcoholic Fatty Liver Disease. Ultrasound in Medicine & Biology, 47. (3), 428-437. doi: 10.1016/j.ultrasmedbio.2020.11.015

Mikolaševic, Ivana, et al. "Accuracy of Controlled Attenuation Parameter and Liver Stiffness Measurement in Patients with Non-alcoholic Fatty Liver Disease." Ultrasound in Medicine & Biology, vol. 47, no. 3, 2021, pp. 428-437. https://doi.org/10.1016/j.ultrasmedbio.2020.11.015

Mikolaševic, Ivana, Viktor Domislović, Mia Klapan, Toni Jurić, Andjela Lukić, Irena Krznarić Zrnić, Dora Fučkar Čupić, et al. "Accuracy of Controlled Attenuation Parameter and Liver Stiffness Measurement in Patients with Non-alcoholic Fatty Liver Disease." Ultrasound in Medicine & Biology 47, no. 3 (2021): 428-437. https://doi.org/10.1016/j.ultrasmedbio.2020.11.015

Mikolaševic, I., et al. (2021) 'Accuracy of Controlled Attenuation Parameter and Liver Stiffness Measurement in Patients with Non-alcoholic Fatty Liver Disease', Ultrasound in Medicine & Biology, 47(3), pp. 428-437. doi: 10.1016/j.ultrasmedbio.2020.11.015

Mikolaševic I, Domislović V, Klapan M, Jurić T, Lukić A, Krznarić Zrnić I, and sur.. Accuracy of Controlled Attenuation Parameter and Liver Stiffness Measurement in Patients with Non-alcoholic Fatty Liver Disease. Ultrasound in Medicine & Biology [Internet]. 2021 March [cited 2024 November 20];47(3):428-437. doi: 10.1016/j.ultrasmedbio.2020.11.015

I. Mikolaševic, et al., "Accuracy of Controlled Attenuation Parameter and Liver Stiffness Measurement in Patients with Non-alcoholic Fatty Liver Disease", Ultrasound in Medicine & Biology, vol. 47, no. 3, pp. 428-437, March 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:557806. [Accessed: 20 November 2024]

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Title (english)Accuracy of Controlled Attenuation Parameter and Liver Stiffness Measurement in Patients with Non-alcoholic Fatty Liver Disease
AuthorIvana Mikolaševic
AuthorViktor Domislović
AuthorMia Klapan
AuthorToni Jurić
AuthorAndjela Lukić
AuthorIrena Krznarić-Zrnić
AuthorDora Fučkar Čupić
AuthorDavor Štimac
AuthorTajana Filipec Kanižaj
AuthorŽeljko Krznaric
AuthorDelfa Radić-Krišto
AuthorSandra Milić
AuthorMarko Martinović
AuthorAron Grubešić
AuthorIvica Grgurević
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
We evaluated the diagnostic accuracy of the controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) measured with either an M or XL probe against liver biopsy (LB) in patients with non-alcoholic fatty liver disease (NAFLD). This study was a cross-sectional prospective study that included 179 NAFLD patients. With a cutoff value for CAP >= 345, we can exclude significant steatosis in 87% (79.4%-92.5%) of our population. With respect to the LSM, the highest accuracy was obtained for F >= F3 (area under the receiver operating characteristic curve [AUROC] = 0.98) and F = F4 (AUROC = 0.98). In a multivariable linear regression model, significant predictors influencing LSM were fibrosis stage (beta = 2.6, p < 0.001) as a positive predictor and lobular inflammation (beta = -0.68, p = 0.04) as a negative predictor, without significant influence after adjustment for CAP and probe type. We found that CAP is a satisfactory method for excluding advanced steatosis, while LSM is a good non-invasive marker for the exclusion of fibrosis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleUltrasound in Medicine & Biology
Numberingvol. 47, no. 3, pp. 428-437
p-ISSN0301-5629
DOIhttps://doi.org/10.1016/j.ultrasmedbio.2020.11.015
URN:NBNurn:nbn:hr:184:557806
Publication2021-03
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0301562920305226
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-09-20 12:03:57