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Scientific paper - Original scientific paper
Nonalcoholic fatty liver disease (NAFLD) – a new factor that interplays between inflammation, malnutrition, and atherosclerosis in elderly hemodialysis patients
Clinical Interventions in Aging, 9 (2014); 1295-1303. https://doi.org/10.2147/CIA.S65382
Mikolašević, Ivana; Lukenda, Vesna; Rački, Sanjin; Milić, Sandra; Sladoje-Martinovic, Branka; Orlić, Lidija

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Mikolašević, I., Lukenda, V., Rački, S., Milić, S., Sladoje Martinovic, B. & Orlić, L. (2014). Nonalcoholic fatty liver disease (NAFLD) – a new factor that interplays between inflammation, malnutrition, and atherosclerosis in elderly hemodialysis patients. Clinical Interventions in Aging, 9., 1295-1303. doi: 10.2147/CIA.S65382

Mikolašević, Ivana, et al. "Nonalcoholic fatty liver disease (NAFLD) – a new factor that interplays between inflammation, malnutrition, and atherosclerosis in elderly hemodialysis patients." Clinical Interventions in Aging, vol. 9, 2014, pp. 1295-1303. https://doi.org/10.2147/CIA.S65382

Mikolašević, Ivana, Vesna Lukenda, Sanjin Rački, Sandra Milić, Branka Sladoje Martinovic and Lidija Orlić. "Nonalcoholic fatty liver disease (NAFLD) – a new factor that interplays between inflammation, malnutrition, and atherosclerosis in elderly hemodialysis patients." Clinical Interventions in Aging 9 (2014): 1295-1303. https://doi.org/10.2147/CIA.S65382

Mikolašević, I., et al. (2014) 'Nonalcoholic fatty liver disease (NAFLD) – a new factor that interplays between inflammation, malnutrition, and atherosclerosis in elderly hemodialysis patients', Clinical Interventions in Aging, 9, pp. 1295-1303. doi: 10.2147/CIA.S65382

Mikolašević I, Lukenda V, Rački S, Milić S, Sladoje Martinovic B, Orlić L. Nonalcoholic fatty liver disease (NAFLD) – a new factor that interplays between inflammation, malnutrition, and atherosclerosis in elderly hemodialysis patients. Clinical Interventions in Aging [Internet]. 2014 August [cited 2025 April 13];9:1295-1303. doi: 10.2147/CIA.S65382

I. Mikolašević, V. Lukenda, S. Rački, S. Milić, B. Sladoje Martinovic and L. Orlić, "Nonalcoholic fatty liver disease (NAFLD) – a new factor that interplays between inflammation, malnutrition, and atherosclerosis in elderly hemodialysis patients", Clinical Interventions in Aging, vol. 9, pp. 1295-1303, August 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:466583. [Accessed: 13 April 2025]

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Title (english)Nonalcoholic fatty liver disease (NAFLD) – a new factor that interplays between inflammation, malnutrition, and atherosclerosis in elderly hemodialysis patients
AuthorIvana Mikolašević
AuthorVesna Lukenda
AuthorSanjin Rački
AuthorSandra Milić
AuthorBranka Sladoje-Martinovic
AuthorLidija Orlić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background/aim: In the past decade, in most regions of the world, an increasing number of adults aged 65 years and older were started on renal replacement therapy each year. In contrast to the general population for whom overnutrition or obesity is associated with increased cardiovascular risk, for patients who are maintained on hemodialysis (HD), malnutrition and malnutrition-inflammation complex syndrome are associated with poor outcome. In recent years, nonalcoholic fatty liver disease... More (NAFLD) has been considered to be the liver manifestation of metabolic syndrome, and the development of NAFLD is strongly associated with all components of metabolic syndrome (arterial hypertension, dyslipidemia, obesity, and diabetes mellitus type 2) in the general population. The primary end point of this study was to determine the patient's survival in relation to nutritional and inflammatory state and the presence or absence of NAFLD. The secondary end point of this analysis was the association among NAFLD and various clinical and laboratory data, with the nutritional and inflammatory state of our elderly HD patients. Methods: Using a single-center, prospective, cohort study design, we followed the progress of 76 patients who were. 65 years and treated with chronic HD for at least 6 months, at the Department of Nephrology, Dialysis and Transplantation. All patients were followed for a minimum of 18 months or until death. Survival was defined as the time from study initiation to death (or end of study, if still alive). Results: The main findings of our study were a remarkable positive correlation between NAFLD and high-sensitivity C-reactive protein (hs-CRP) (r=0.659; P<0.0001) and consequent negative correlation with the nutritional parameter, serum albumin (r=-0.321; P=0.004). Interestingly, we showed that in contrast to the general population, where NAFLD is associated with obesity, in the present study, there was no statistically significant association between NAFLD and overnutrition in elderly HD patients. Furthermore, the presence of NAFLD, low serum albumin levels, and high hs-CRP were strong predictors of poor outcome in our elderly HD patients. Conclusion: Our results indicated that NAFLD probably interplays between inflammation, malnutrition, and atherosclerosis in elderly HD patients. NAFLD could be a new factor that contributes to type 2 malnutrition in elderly HD patients, who may be amenable to adequate nutritional and HD support. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleClinical Interventions in Aging
Numberingvol. 9, pp. 1295-1303
e-ISSN1178-1998
DOIhttps://doi.org/10.2147/CIA.S65382
URN:NBNurn:nbn:hr:184:466583
Publication2014-08
Document URLhttp://www.dovepress.com/nonalcoholic-fatty-liver-disease-nafld-ndash-a-new-factor-that-interpl-peer-reviewed-article-CIA
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2022-09-20 10:05:45
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