prikaz prve stranice dokumenta Nonalcoholic fatty liver disease (NAFLD) proven by transient elastography in patients with coronary heart disease
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Scientific paper - Original scientific paper
Nonalcoholic fatty liver disease (NAFLD) proven by transient elastography in patients with coronary heart disease
Wiener klinische Wochenschrift, 126 (2014), 15-16; 474-479. https://doi.org/10.1007/s00508-014-0538-0
Mikolašević, Ivana; Orlic, Lidija; Milić, Sandra; Lukenda, Vesna; Rački, Sanjin; Štimac, Davor; Avdovic, Ervin; Zaputović, Luka

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Mikolašević, I., Orlic, L., Milić, S., Lukenda, V., Rački, S., Štimac, D. ... Zaputović, L. (2014). Nonalcoholic fatty liver disease (NAFLD) proven by transient elastography in patients with coronary heart disease. Wiener klinische Wochenschrift, 126. (15-16), 474-479. doi: 10.1007/s00508-014-0538-0

Mikolašević, Ivana, et al. "Nonalcoholic fatty liver disease (NAFLD) proven by transient elastography in patients with coronary heart disease." Wiener klinische Wochenschrift, vol. 126, no. 15-16, 2014, pp. 474-479. https://doi.org/10.1007/s00508-014-0538-0

Mikolašević, Ivana, Lidija Orlic, Sandra Milić, Vesna Lukenda, Sanjin Rački, Davor Štimac, Ervin Avdovic and Luka Zaputović. "Nonalcoholic fatty liver disease (NAFLD) proven by transient elastography in patients with coronary heart disease." Wiener klinische Wochenschrift 126, no. 15-16 (2014): 474-479. https://doi.org/10.1007/s00508-014-0538-0

Mikolašević, I., et al. (2014) 'Nonalcoholic fatty liver disease (NAFLD) proven by transient elastography in patients with coronary heart disease', Wiener klinische Wochenschrift, 126(15-16), pp. 474-479. doi: 10.1007/s00508-014-0538-0

Mikolašević I, Orlic L, Milić S, Lukenda V, Rački S, Štimac D, and sur.. Nonalcoholic fatty liver disease (NAFLD) proven by transient elastography in patients with coronary heart disease. Wiener klinische Wochenschrift [Internet]. 2014 [cited 2024 May 31];126(15-16):474-479. doi: 10.1007/s00508-014-0538-0

I. Mikolašević, et al., "Nonalcoholic fatty liver disease (NAFLD) proven by transient elastography in patients with coronary heart disease", Wiener klinische Wochenschrift, vol. 126, no. 15-16, pp. 474-479, 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:568204. [Accessed: 31 May 2024]

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Metadata
Title (english)Nonalcoholic fatty liver disease (NAFLD) proven by transient elastography in patients with coronary heart disease
AuthorIvana Mikolašević
AuthorLidija Orlic
AuthorSandra Milić
AuthorVesna Lukenda
AuthorSanjin Rački
AuthorDavor Štimac
AuthorErvin Avdovic
AuthorLuka Zaputović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
The relationship between nonalcoholic fatty liver disease (NAFLD) and coronary heart disease (CHD) is poorly understood. In the present study, we aimed to assess the frequency of NAFLD in CHD patients by using a new diagnostic tool: transient elastography (TE; Fibroscan(A (R))-CAP). Clarification of the present study may help to provide a new noninvasive tool for the assessment of NAFLD in this specific population of patients and may be of clinical importance in planning preventive strategies in high-risk patients. A total of 75 patients with proven CHD were enrolled. Liver stiffness was used to assess liver fibrosis, and controlled attenuation parameter (CAP) was used to detect and quantify liver steatosis by using Fibroscan(A (R)) (Echosens, Paris, France). By CAP being implemented on TE, both liver steatosis and fibrosis can be evaluated simultaneously. Of the 75 patients, 45 (60 %) had CAP > 238 dBm(-1) and, by definition, NAFLD. Among the patients with NAFLD, 24 (53.3 %) had, in addition, liver stiffness > 7 kPa. Analyzing the influence of the degree of liver steatosis (expressed by CAP values) on the degree of CHD (defined by single or multiple vessels involved), we found that patients with multiple vessels involved had higher CAP values (p = 0.002). Furthermore, we noticed that significantly more patients with multiple vessels involved had liver stiffness > 7 kPa (p < 0.0001) indicating the more severe form of NAFLD in those patients. The main finding of our study is that TE provides the opportunity of noninvasive screening for NAFLD in CHD patients, as it is a quick, simple, reliable, and repeatable method and more cost-effective than liver biopsy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleWiener klinische Wochenschrift
Numberingvol. 126, no. 15-16, pp. 474-479
p-ISSN0043-5325
e-ISSN1613-7671
DOIhttps://doi.org/10.1007/s00508-014-0538-0
URN:NBNurn:nbn:hr:184:568204
Publication2014
Document URLhttp://link.springer.com/10.1007/s00508-014-0538-0
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-09-20 07:15:53