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master's thesis
Neuroplastičnost uzrokovana halucinogenima u razumijevanju fiziologije mozga
2022. urn:nbn:hr:184:722813
Miličević, Kristijan
University of Rijeka
Faculty of Medicine
Department of Physiology, Immunology and Pathophxsiology

Cite this document

Miličević, K. (2022). Neuroplastičnost uzrokovana halucinogenima u razumijevanju fiziologije mozga (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:722813

Miličević, Kristijan. "Neuroplastičnost uzrokovana halucinogenima u razumijevanju fiziologije mozga." Master's thesis, University of Rijeka, Faculty of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:184:722813

Miličević, Kristijan. "Neuroplastičnost uzrokovana halucinogenima u razumijevanju fiziologije mozga." Master's thesis, University of Rijeka, Faculty of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:184:722813

Miličević, K. (2022). 'Neuroplastičnost uzrokovana halucinogenima u razumijevanju fiziologije mozga', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 29 October 2024, https://urn.nsk.hr/urn:nbn:hr:184:722813

Miličević K. Neuroplastičnost uzrokovana halucinogenima u razumijevanju fiziologije mozga [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2022 [cited 2024 October 29] Available at: https://urn.nsk.hr/urn:nbn:hr:184:722813

K. Miličević, "Neuroplastičnost uzrokovana halucinogenima u razumijevanju fiziologije mozga", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:184:722813

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Metadata
TitleNeuroplastičnost uzrokovana halucinogenima u razumijevanju fiziologije mozga
Title (english)Hallucinogen induced neuroplasticity in understanding the physiology of the brain
AuthorKristijan Miličević
MentorNatalia Kučić (mentor)
Committee memberJasenka Mršić-Pelčić (predsjednik povjerenstva)
Committee memberIka Rončević-Gržeta (član povjerenstva)
Committee memberIvana Marić (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Rijeka
Defense date and country2022-09-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract
Klasični halucinogeni, DMT, 5-MeO-DMT, LSD, psilocibin, meskalin, DOI I DOB, posjeduju izraženu sposobnost mijenjanja stanja svijesti. Komponente svijesti kao što su percepcija vanjskog svijeta, emocije, kognicija kao i osjećaj vlastite subjektivnosti bivaju drastično promijenjeni djelovanjem halucinogena. Klasični halucinogeni djeluju putem različitih receptora u mozgu od kojih mnoštvo pripada serotonergičnim receptorima. LSD pokazuje najveću farmakodinamsku sveobuhvatnost te se osim uz serotonergične veže i na dopaminske i adrenergične receptore. Smatra se da glavninu učinaka postižu djelovanjem na 5-HT2A receptore gusto izražene u kortikalnim i subkortikalnim strukturama mozga. Strukturna i funkcionalna plastičnost mozga izazvana halucinogenima je jedan od novijih pravaca u istraživanju. Uočena je mogućnost halucinogena da izazivaju promjene na razini morfologije neurona, sinapsi, te aktivnosti i komunikaciji neuronskih mreža. Cilj ovog rada je pregledom dostupne literature navesti saznanja o utjecaju halucinogena na strukturnu i funkcionalnu plastičnost mozga te ih povezati sa fenomenologijom i potencijano mogućim terapeutskim učincima.
Abstract (english)
Classic hallucinogens, DMT, 5-MeO-DMT, LSD, psilocybin, mescaline, DOI and DOB, are a class of drugs with a pronounced ability of altering the normal state of consciousness. Components of consciousness such as perception, emotions, cognition and the sense of our own subjectivity are drastically altered by hallucinogens. Classic hallucinogens act on various receptors in the brain most of which are of the serotonergic type. LSD is imbued with the largest pharmacodynamic versatility as it also binds to dopaminergic and adrenergic receptors. It is believed that most of the effects of hallucinogens are a consequence of their interaction with the 5-HT2A receptor which is densely expressed within cortical and subcortical structures of the brain. Structural and functional plasticity induced by classic hallucinogens is one of the new directions in research. Discoveries of hallucinogens ability to induce changes upon the morphology of neurons, synapses and the activity and connectivity within and among neural network have been made. The goal of this paper is, by reviewing the available literature, to specify the discoveries about the effects of classic hallucinogens on structural and functional plasticity and connect them with the phenomenology and potential therapeutic effects.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:722813
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-09-01 15:58:37