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Scientific paper - Review paper
The role of direct oral anticoagulants in the era of COVID-19: are antiviral therapy and pharmacogenetics limiting factors?
Croatian medical journal, 63 (2022); 287-294. urn:nbn:hr:184:546698
Roguljić, Hrvoje; Arambašić, Jerko; Ninčević, Vjera; Kuna, Lucija; Šesto, Igor; Tabll, Ashraf; Smolić, Robert; Včev, Aleksandar; Primorac, Dragan; Wu, George; Smolić, Martina

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Roguljić, H., Arambašić, J., Ninčević, V., Kuna, L., Šesto, I., Tabll, A. ... Smolić, M. (2022). The role of direct oral anticoagulants in the era of COVID-19: are antiviral therapy and pharmacogenetics limiting factors?. Croatian medical journal, 63., 287-294. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:546698

Roguljić, Hrvoje, et al. "The role of direct oral anticoagulants in the era of COVID-19: are antiviral therapy and pharmacogenetics limiting factors?." Croatian medical journal, vol. 63, 2022, pp. 287-294. https://urn.nsk.hr/urn:nbn:hr:184:546698

Roguljić, Hrvoje, Jerko Arambašić, Vjera Ninčević, Lucija Kuna, Igor Šesto, Ashraf Tabll, Robert Smolić, et al. "The role of direct oral anticoagulants in the era of COVID-19: are antiviral therapy and pharmacogenetics limiting factors?." Croatian medical journal 63 (2022): 287-294. https://urn.nsk.hr/urn:nbn:hr:184:546698

Roguljić, H., et al. (2022) 'The role of direct oral anticoagulants in the era of COVID-19: are antiviral therapy and pharmacogenetics limiting factors?', Croatian medical journal, 63, pp. 287-294. Available at: https://urn.nsk.hr/urn:nbn:hr:184:546698 (Accessed 05 May 2024)

Roguljić H, Arambašić J, Ninčević V, Kuna L, Šesto I, Tabll A, and sur.. The role of direct oral anticoagulants in the era of COVID-19: are antiviral therapy and pharmacogenetics limiting factors?. Croatian medical journal [Internet]. 2022 [cited 2024 May 05];63:287-294. Available at: https://urn.nsk.hr/urn:nbn:hr:184:546698

H. Roguljić, et al., "The role of direct oral anticoagulants in the era of COVID-19: are antiviral therapy and pharmacogenetics limiting factors?", Croatian medical journal, vol. 63, pp. 287-294, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:546698. [Accessed: 05 May 2024]

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Metadata
Title (english)The role of direct oral anticoagulants in the era of COVID-19: are antiviral therapy and pharmacogenetics limiting factors?
AuthorHrvoje Roguljić
AuthorJerko Arambašić
AuthorVjera Ninčević
AuthorLucija Kuna
AuthorIgor Šesto
AuthorAshraf Tabll
AuthorRobert Smolić
AuthorAleksandar Včev
AuthorDragan Primorac
AuthorGeorge Wu
AuthorMartina Smolić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
In patients with COVID-19, thromboinflammation is one of the main causes of morbidity and mortality, which makes anticoagulation an integral part of treatment. However, pharmacodynamic and pharmacokinetic properties of direct oral anticoagulants (DOACs) limit the use of this class of anticoagulants in COVID-19 patients due to a significant interference with antiviral agents. DOACs use in COVID-19 hospitalized patients is currently not recommended. Furthermore, patients already on oral anticoagulant drugs should be switched to heparin at hospital admission. Nevertheless, outpatients with a confirmed diagnosis of COVID-19 are recommended to continue prior DOAC therapy. More studies are required to clarify the pathogenesis of COVID-19-induced derangement of the coagulation system in order to recommend an appropriate anticoagulant treatment.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian medical journal
Numberingvol. 63, pp. 287-294
p-ISSN0353-9504
URN:NBNurn:nbn:hr:184:546698
Publication2022
Document URLhttp://bib.irb.hr/1205752
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-08-12 11:42:37