Aim: The aim of this paper is to present the course of treatment of patients diagnosed with necrotizing enterocolitis (NEC) at the Clinic for Pediatric Surgery of the Clinical Hospital Center Rijeka and determine how certain factors affect the outcome of the disease. Subjects and Procedures: The retrospective study included surgically treated patients with suspected or diagnosed NEC between January 2011 and December 2020. Data were collected from the integrated hospital information system. They were graphically and statistically processed in MS Excel. Results: The examined sample consisted of 10 patients. All subjects were preterm infants <37 weeks gestation, of which 50% were classified as distinct preterm infants with <28 weeks gestation and birth weight <1000g. With clinical signs of NEC, pneumoperitoneum was radiologically proven in 80% of subjects, although all patients had intestinal perforation. In all observed patients, the surgical approach was exploratory laparotomy. Of the 10 patients presented, 5 died, 2 showed signs of psychomotor inequality for age, 1 weight loss within the first year. The influence of the observed variables (gestational age, birth weight, sex, age on the day of surgery, necrosis findings, comorbidities) on the outcome of the disease was not statistically significant. Conclusion: The study did not reveal any statistically significant correlation between the observed variables and the outcome of the disease. Given that previous studies have proven some of these variables to be significant, we believe that more extensive research is needed on a larger number of respondents with more data.