prikaz prve stranice dokumenta QUETIAPINE ADD-ON THERAPY MAY IMPROVE PERSISTENT SLEEP DISTURBANCES IN PATIENTS WITH PTSD ON STABILE COMBINED SSRI AND BENZODIAZEPINE COMBINATION: A ONE-GROUP PRETEST-POSTTEST STUDY
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Scientific paper - Original scientific paper
QUETIAPINE ADD-ON THERAPY MAY IMPROVE PERSISTENT SLEEP DISTURBANCES IN PATIENTS WITH PTSD ON STABILE COMBINED SSRI AND BENZODIAZEPINE COMBINATION: A ONE-GROUP PRETEST-POSTTEST STUDY
Psychiatria Danubina, 34 (2022), 2; 245-252. https://doi.org/10.24869/psyd.2022.245
Vilibić, Maja; Peitl, Vjekoslav; Živković, Maja; Vlatković, Suzana; Ljubičić Bistrović, Ivana; Ljubičić, Rudolf; Matošić, Ana; Karlović, Dalibor

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Vilibić, M., Peitl, V., Živković, M., Vlatković, S., Ljubičić Bistrović, I., Ljubičić, R. ... Karlović, D. (2022). QUETIAPINE ADD-ON THERAPY MAY IMPROVE PERSISTENT SLEEP DISTURBANCES IN PATIENTS WITH PTSD ON STABILE COMBINED SSRI AND BENZODIAZEPINE COMBINATION: A ONE-GROUP PRETEST-POSTTEST STUDY. Psychiatria Danubina, 34. (2), 245-252. doi: 10.24869/psyd.2022.245

Vilibić, Maja, et al. "QUETIAPINE ADD-ON THERAPY MAY IMPROVE PERSISTENT SLEEP DISTURBANCES IN PATIENTS WITH PTSD ON STABILE COMBINED SSRI AND BENZODIAZEPINE COMBINATION: A ONE-GROUP PRETEST-POSTTEST STUDY." Psychiatria Danubina, vol. 34, no. 2, 2022, pp. 245-252. https://doi.org/10.24869/psyd.2022.245

Vilibić, Maja, Vjekoslav Peitl, Maja Živković, Suzana Vlatković, Ivana Ljubičić Bistrović, Rudolf Ljubičić, Ana Matošić and Dalibor Karlović. "QUETIAPINE ADD-ON THERAPY MAY IMPROVE PERSISTENT SLEEP DISTURBANCES IN PATIENTS WITH PTSD ON STABILE COMBINED SSRI AND BENZODIAZEPINE COMBINATION: A ONE-GROUP PRETEST-POSTTEST STUDY." Psychiatria Danubina 34, no. 2 (2022): 245-252. https://doi.org/10.24869/psyd.2022.245

Vilibić, M., et al. (2022) 'QUETIAPINE ADD-ON THERAPY MAY IMPROVE PERSISTENT SLEEP DISTURBANCES IN PATIENTS WITH PTSD ON STABILE COMBINED SSRI AND BENZODIAZEPINE COMBINATION: A ONE-GROUP PRETEST-POSTTEST STUDY', Psychiatria Danubina, 34(2), pp. 245-252. doi: 10.24869/psyd.2022.245

Vilibić M, Peitl V, Živković M, Vlatković S, Ljubičić Bistrović I, Ljubičić R, and sur.. QUETIAPINE ADD-ON THERAPY MAY IMPROVE PERSISTENT SLEEP DISTURBANCES IN PATIENTS WITH PTSD ON STABILE COMBINED SSRI AND BENZODIAZEPINE COMBINATION: A ONE-GROUP PRETEST-POSTTEST STUDY. Psychiatria Danubina [Internet]. 2022 [cited 2024 November 27];34(2):245-252. doi: 10.24869/psyd.2022.245

M. Vilibić, et al., "QUETIAPINE ADD-ON THERAPY MAY IMPROVE PERSISTENT SLEEP DISTURBANCES IN PATIENTS WITH PTSD ON STABILE COMBINED SSRI AND BENZODIAZEPINE COMBINATION: A ONE-GROUP PRETEST-POSTTEST STUDY", Psychiatria Danubina, vol. 34, no. 2, pp. 245-252, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:700317. [Accessed: 27 November 2024]

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Title (english)QUETIAPINE ADD-ON THERAPY MAY IMPROVE PERSISTENT SLEEP DISTURBANCES IN PATIENTS WITH PTSD ON STABILE COMBINED SSRI AND BENZODIAZEPINE COMBINATION: A ONE-GROUP PRETEST-POSTTEST STUDY
AuthorMaja Vilibić
AuthorVjekoslav Peitl
AuthorMaja Živković
AuthorSuzana Vlatković
AuthorIvana Ljubičić Bistrović
AuthorRudolf Ljubičić
AuthorAna Matošić
AuthorDalibor Karlović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
Background: To assess potential benefits of quetiapine for persistent sleep disturbances in patients with posttraumatic stress disorder (PTSD) on stable combined SSRI and benzodiazepine therapy, who previously failed to respond to various benzodiazepine and non-benzodiazepine hypnotic adjuvant treatment as well as to first-generation antipsychotic add-on treatment. Subjects and methods: Fifty-two male PTSD outpatients on stable combination treatment with SSRI and benzodiazepines, with persistent sleep disturbances not responding to prescription of zolpidem, flurazepam, nitrazepam, promazine, and levopromazine, were assessed for sleep disturbances improvements after prescription of quetiapine in the evening. Each patient met both ICD-10 and DSM-IV criteria for PTSD. Psychiatric comorbidity and premorbidity were excluded using the Mini-International Neuropsychiatric Interview (MINI). Improvement on the CAPS recurrent distressing dream item, reduction in the amount of time needed to fall asleep, prolongation of sleep duration, and reduction in average number of arousals per night in the last 7 days before the assessment period were used as efficacy measures. Results: All sleep-related parameters improved significantly at the end of a five-week follow-up: sleep duration increased by one hour (p<0.001), sleep latency decreased by 52.5 minutes (p<0.001), median number of arousals per night decreased from two to one (p<0.001), CAPS recurrent distressing dream item median decreased from five to four (p<0.001), and the number of patients dissatisfied with their sleep quality and quantity decreased from 45 to two (p<0.001). Conclusion: Quetiapine prescribed in the evening may be successful therapy for persistent sleep disturbances in patients with PTSD and generally good response to an SSRI and benzodiazepine combination, who previously failed to respond to some of the usual hypnotic medication or addition of first-generation antipsychotics: zolpidem, flurazepam, nitrazepam, promazine, and levopromazine.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePsychiatria Danubina
Numberingvol. 34, no. 2, pp. 245-252
p-ISSN0353-5053
DOIhttps://doi.org/10.24869/psyd.2022.245
URN:NBNurn:nbn:hr:184:700317
Publication2022
Document URLhttps://hrcak.srce.hr/280016
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-07-08 06:56:44