prikaz prve stranice dokumenta Murine cytomegalovirus regulation of NKG2D ligands
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Scientific paper - Review paper
Murine cytomegalovirus regulation of NKG2D ligands
Medical Microbiology and Immunology, 197 (2008), 2; 159-166. urn:nbn:hr:184:246576
Lenac, Tihana; Arapović, Jurica; Traven, Luka; Krmpotić, Astrid; Jonjić, Stipan

Cite this document

Lenac, T., Arapović, J., Traven, L., Krmpotić, A. & Jonjić, S. (2008). Murine cytomegalovirus regulation of NKG2D ligands. Medical Microbiology and Immunology, 197. (2), 159-166. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:246576

Lenac, Tihana, et al. "Murine cytomegalovirus regulation of NKG2D ligands." Medical Microbiology and Immunology, vol. 197, no. 2, 2008, pp. 159-166. https://urn.nsk.hr/urn:nbn:hr:184:246576

Lenac, Tihana, Jurica Arapović, Luka Traven, Astrid Krmpotić and Stipan Jonjić. "Murine cytomegalovirus regulation of NKG2D ligands." Medical Microbiology and Immunology 197, no. 2 (2008): 159-166. https://urn.nsk.hr/urn:nbn:hr:184:246576

Lenac, T., et al. (2008) 'Murine cytomegalovirus regulation of NKG2D ligands', Medical Microbiology and Immunology, 197(2), pp. 159-166. Available at: https://urn.nsk.hr/urn:nbn:hr:184:246576 (Accessed 07 November 2024)

Lenac T, Arapović J, Traven L, Krmpotić A, Jonjić S. Murine cytomegalovirus regulation of NKG2D ligands. Medical Microbiology and Immunology [Internet]. 2008 [cited 2024 November 07];197(2):159-166. Available at: https://urn.nsk.hr/urn:nbn:hr:184:246576

T. Lenac, J. Arapović, L. Traven, A. Krmpotić and S. Jonjić, "Murine cytomegalovirus regulation of NKG2D ligands", Medical Microbiology and Immunology, vol. 197, no. 2, pp. 159-166, 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:246576. [Accessed: 07 November 2024]

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Metadata
Title (english)Murine cytomegalovirus regulation of NKG2D ligands
AuthorTihana Lenac
AuthorJurica Arapović
AuthorLuka Traven
AuthorAstrid Krmpotić
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes morbidity risk in immunologically suppressed and immunodeficient patients including congenital infections. Approaches to curb the consequences of HCMV infections are restricted by a lack of complete understanding of viral pathogenesis. The infection of mice with murine cytomegalovirus (MCMV) as a model of HCMV infection has been particularly useful in elucidating the role of innate and adaptive immune response mechanisms. A large number of cytomegalovirus genes modulate the innate and the adaptive host immune response. The products of several MCMV genes are involved in subverting the natural killer (NK) cell response by down-modulating cellular ligands for the NKG2D receptor expressed on NK cells and CD8(+) T cells. Mutant viruses lacking these immunoevasion genes are attenuated with respect to virus growth in vivo. Given the importance of the NKG2D receptor in controlling both NK- and T cell-mediated immunity, it is of tremendous importance to understand the molecular mechanisms and consequences of viral regulation of the NKG2D ligands.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedical Microbiology and Immunology
Numberingvol. 197, no. 2, pp. 159-166
p-ISSN0300-8584
URN:NBNurn:nbn:hr:184:246576
Publication2008
ProjectNumber: 062-0621261-1263
Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Title (english): Molecular mechanisms of immune evasion by cytomegalovirus
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0621261-1268
Title (croatian): Uloga imunosubverzivnih citomegalovirusnih gena u latenciji
Title (english): The role of cytomegalovirus immunoevasion genes in latency
Leader: Astrid Krmpotić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://bib.irb.hr/379153
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-03-24 14:03:11