prikaz prve stranice dokumenta Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection
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Scientific paper - Original scientific paper
Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection
Infection and Immunity, 65 (1997), 5; 1754-1760. https://doi.org/10.1128/iai.65.5.1754-1760.1997
Rukavina, Tomislav; Tíćac, Brigita; Šuša, Miodrag; Jendrike, N; Jonjíć, Stipan; Lučin, Pero; Marre, R; Doríć, Miljenko; Trautmann, M

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Rukavina, T., Tíćac, B., Šuša, M., Jendrike, N., Jonjíć, S., Lučin, P. ... Trautmann, M. (1997). Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection. Infection and Immunity, 65. (5), 1754-1760. doi: 10.1128/iai.65.5.1754-1760.1997

Rukavina, Tomislav, et al. "Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection." Infection and Immunity, vol. 65, no. 5, 1997, pp. 1754-1760. https://doi.org/10.1128/iai.65.5.1754-1760.1997

Rukavina, Tomislav, Brigita Tíćac, Miodrag Šuša, N Jendrike, Stipan Jonjíć, Pero Lučin, R Marre, Miljenko Doríć and M Trautmann. "Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection." Infection and Immunity 65, no. 5 (1997): 1754-1760. https://doi.org/10.1128/iai.65.5.1754-1760.1997

Rukavina, T., et al. (1997) 'Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection', Infection and Immunity, 65(5), pp. 1754-1760. doi: 10.1128/iai.65.5.1754-1760.1997

Rukavina T, Tíćac B, Šuša M, Jendrike N, Jonjíć S, Lučin P, and sur.. Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection. Infection and Immunity [Internet]. 1997 May [cited 2024 July 09];65(5):1754-1760. doi: 10.1128/iai.65.5.1754-1760.1997

T. Rukavina, et al., "Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection", Infection and Immunity, vol. 65, no. 5, pp. 1754-1760, May 1997. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:879758. [Accessed: 09 July 2024]

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Metadata
Title (english)Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection
AuthorTomislav Rukavina
AuthorBrigita Tíćac
AuthorMiodrag Šuša
AuthorN Jendrike
AuthorStipan Jonjíć
AuthorPero Lučin
AuthorR Marre
AuthorMiljenko Doríć
AuthorM Trautmann
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
An O-antigen-specific murine monoclonal antibody (MAb) directed against an immunodominant epitope expressed on Klebsiella O1, O6, and O8 lipopolysaccharides (LPS) was examined with respect to its binding to nonencapsulated and encapsulated bacterial cells and its ability to protect against lethal murine Klebsiella sepsis. While the MAb (clone Ru-O1, mouse immunoglobulin G2b) bound well to nonencapsulated organisms of the O1 serogroup, binding was significantly, but not completely, abolished by the presence of the K2 capsule. In a model of experimental Klebsiella peritonitis and sepsis induced by a virulent O1:K2 serogroup strain, higher doses of anti-LPS MAb Ru-O1 than of a previously described anticapsular MAb specific for the K2 capsular polysaccharide were needed to provide protection. However, high-dose (40 microg/g of body weight) pretreatment with anti-LPS MAb Ru-O1 significantly reduced bacterial dissemination to various organs as well as macroscopic and histologic pulmonary alterations. Thus, since the number of Klebsiella capsular antigens occurring in clinical material is too large to be completely "covered" by a K-antigen-specific hyperimmunoglobulin preparation, O-antigen-specific antibodies may supplement K-antigen-specific immunoprophylaxis and -therapy of clinical Klebsiella infection.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInfection and Immunity
Numberingvol. 65, no. 5, pp. 1754-1760
p-ISSN0019-9567
e-ISSN1098-5522
DOIhttps://doi.org/10.1128/iai.65.5.1754-1760.1997
URN:NBNurn:nbn:hr:184:879758
Publication1997-05
Document URLhttps://journals.asm.org/doi/10.1128/iai.65.5.1754-1760.1997
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-03-17 21:51:40