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Scientific paper - Case study
NEFROPATIJA POVEZANA S VARFARINOM – PRIKAZ BOLESNIKA NA TEMELJU BIOPSIJE BUBREGA I PREGLED LITERATURE
Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, 70 (2016), Suplement 2; 76-80. urn:nbn:hr:184:279249
Mikolašević, Ivana; Rački, Sanjin; Pavletić Peršić, Martina; Đorđević, Gordana; Mavrinac, Vojko; Orlić, Lidija

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Mikolašević, I., Rački, S., Pavletić Peršić, M., Đorđević, G., Mavrinac, V. & Orlić, L. (2016). NEFROPATIJA POVEZANA S VARFARINOM – PRIKAZ BOLESNIKA NA TEMELJU BIOPSIJE BUBREGA I PREGLED LITERATURE. Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, 70. (Suplement 2), 76-80. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:279249

Mikolašević, Ivana, et al. "NEFROPATIJA POVEZANA S VARFARINOM – PRIKAZ BOLESNIKA NA TEMELJU BIOPSIJE BUBREGA I PREGLED LITERATURE." Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, vol. 70, no. Suplement 2, 2016, pp. 76-80. https://urn.nsk.hr/urn:nbn:hr:184:279249

Mikolašević, Ivana, Sanjin Rački, Martina Pavletić Peršić, Gordana Đorđević, Vojko Mavrinac and Lidija Orlić. "NEFROPATIJA POVEZANA S VARFARINOM – PRIKAZ BOLESNIKA NA TEMELJU BIOPSIJE BUBREGA I PREGLED LITERATURE." Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske 70, no. Suplement 2 (2016): 76-80. https://urn.nsk.hr/urn:nbn:hr:184:279249

Mikolašević, I., et al. (2016) 'NEFROPATIJA POVEZANA S VARFARINOM – PRIKAZ BOLESNIKA NA TEMELJU BIOPSIJE BUBREGA I PREGLED LITERATURE', Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, 70(Suplement 2), pp. 76-80. Available at: https://urn.nsk.hr/urn:nbn:hr:184:279249 (Accessed 18 December 2024)

Mikolašević I, Rački S, Pavletić Peršić M, Đorđević G, Mavrinac V, Orlić L. NEFROPATIJA POVEZANA S VARFARINOM – PRIKAZ BOLESNIKA NA TEMELJU BIOPSIJE BUBREGA I PREGLED LITERATURE. Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske [Internet]. 2016 [cited 2024 December 18];70(Suplement 2):76-80. Available at: https://urn.nsk.hr/urn:nbn:hr:184:279249

I. Mikolašević, S. Rački, M. Pavletić Peršić, G. Đorđević, V. Mavrinac and L. Orlić, "NEFROPATIJA POVEZANA S VARFARINOM – PRIKAZ BOLESNIKA NA TEMELJU BIOPSIJE BUBREGA I PREGLED LITERATURE", Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, vol. 70, no. Suplement 2, pp. 76-80, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:279249. [Accessed: 18 December 2024]

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Metadata
Title (croatian)NEFROPATIJA POVEZANA S VARFARINOM – PRIKAZ BOLESNIKA NA TEMELJU BIOPSIJE BUBREGA I PREGLED LITERATURE
Title (english)WARFARIN-RELATED NEPHROPATHY – A CASE REPORT ON RENAL BIOPSY AND REVIEW OF THE LITERATURE
AuthorIvana Mikolašević
AuthorSanjin Rački
AuthorMartina Pavletić Peršić
AuthorGordana Đorđević
AuthorVojko Mavrinac
AuthorLidija Orlić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (croatian)
Nefropatija povezana s varfarinom (WRN) je odnedavno prepoznato stanje u bolesnika s kroničnom bolešću bubrega (KBB). WRN je klinički prepoznata kao epizoda neobjašnjivog akutnog oštećenja bubrega (AOB). Definira se kao povećanje kreatinina u serumu (sCR) >0,3 mg/dL (26,5 micromol/L) unutar tjedna INR mjerenja >3,0 u bolesnika liječenog varfarinom bez klinički utvrđenog krvarenja. Zbog toga terapija varfarinom može dovesti do AOB uzrokujući glomerularno krvarenje i opstrukciju bubrežnih tubula odljevnim cilindrima eritrocita. Čini se da WRN ubrzava napredovanje KBB i u osjetljivih bolesnika povećava rizik od smrtnog ishoda.Izvješćujemo o biopsiji bubrega u bolesnika na terapiji varfarinom s neobjašnjivim AOB i hematurijom povezanom s povećanim INR. Namjera nam je naglasiti potrebu interdisciplinarnog pristupa bolesnicima na terapiji varfarinom.
Abstract (english)
Warfarin-related nephropathy (WRN) is a recently recognized condition in patients with chronic kidney disease (CKD). WRN is clinically detected as an episode of unexplained acute kidney injury (AKI). It is defined as a serum creatinine (sCR) increase >0.3 mg/dL (26.5 μmol/L) within one week of an international normalized ratio (INR) measurement >3.0 in a patient treated with warfarin without clinical evidence of hemorrhage. Therefore, warfarin therapy can result in AKI by causing glomerular hemorrhage and renal tubular obstruction by red blood cell casts. WRN appears to accelerate the rate of CKD progression and increase the risk of death in susceptible patients. We report on renal biopsy in a patient on warfarin therapy with unexplained AKI and hematuria associated with increased INR. We would like to stress the necessity of an interdisciplinary approach to patients on warfarin therapy.
Keywords (croatian)
Keywords (english)
Languagecroatian
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske
Numberingvol. 70, no. Suplement 2, pp. 76-80
p-ISSN1330-0164
e-ISSN1848-8897
URN:NBNurn:nbn:hr:184:279249
Publication2016
Document URLhttps://hrcak.srce.hr/180170
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-03-15 07:51:45