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Scientific paper - Original scientific paper
The Real-Life Effectiveness and Care Patterns of Diabetes Management Study for Balkan Region (Slovenia, Croatia, Serbia, Bulgaria): A Multicenter, Observational, Cross-Sectional Study
Diabetes Therapy, 8 (2017), 4; 929-940. https://doi.org/10.1007/s13300-017-0288-x
Klobučar Majanović, Sanja; Janež, Andrej; Lefterov, Ivaylo; Tasić, Sanja; Cikač, Tatjana

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Klobučar Majanović, S., Janež, A., Lefterov, I., Tasić, S. & Cikač, T. (2017). The Real-Life Effectiveness and Care Patterns of Diabetes Management Study for Balkan Region (Slovenia, Croatia, Serbia, Bulgaria): A Multicenter, Observational, Cross-Sectional Study. Diabetes Therapy, 8. (4), 929-940. doi: 10.1007/s13300-017-0288-x

Klobučar Majanović, Sanja, et al. "The Real-Life Effectiveness and Care Patterns of Diabetes Management Study for Balkan Region (Slovenia, Croatia, Serbia, Bulgaria): A Multicenter, Observational, Cross-Sectional Study." Diabetes Therapy, vol. 8, no. 4, 2017, pp. 929-940. https://doi.org/10.1007/s13300-017-0288-x

Klobučar Majanović, Sanja, Andrej Janež, Ivaylo Lefterov, Sanja Tasić and Tatjana Cikač. "The Real-Life Effectiveness and Care Patterns of Diabetes Management Study for Balkan Region (Slovenia, Croatia, Serbia, Bulgaria): A Multicenter, Observational, Cross-Sectional Study." Diabetes Therapy 8, no. 4 (2017): 929-940. https://doi.org/10.1007/s13300-017-0288-x

Klobučar Majanović, S., et al. (2017) 'The Real-Life Effectiveness and Care Patterns of Diabetes Management Study for Balkan Region (Slovenia, Croatia, Serbia, Bulgaria): A Multicenter, Observational, Cross-Sectional Study', Diabetes Therapy, 8(4), pp. 929-940. doi: 10.1007/s13300-017-0288-x

Klobučar Majanović S, Janež A, Lefterov I, Tasić S, Cikač T. The Real-Life Effectiveness and Care Patterns of Diabetes Management Study for Balkan Region (Slovenia, Croatia, Serbia, Bulgaria): A Multicenter, Observational, Cross-Sectional Study. Diabetes Therapy [Internet]. 2017 [cited 2024 May 08];8(4):929-940. doi: 10.1007/s13300-017-0288-x

S. Klobučar Majanović, A. Janež, I. Lefterov, S. Tasić and T. Cikač, "The Real-Life Effectiveness and Care Patterns of Diabetes Management Study for Balkan Region (Slovenia, Croatia, Serbia, Bulgaria): A Multicenter, Observational, Cross-Sectional Study", Diabetes Therapy, vol. 8, no. 4, pp. 929-940, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:831778. [Accessed: 08 May 2024]

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Metadata
Title (english)The Real-Life Effectiveness and Care Patterns of Diabetes Management Study for Balkan Region (Slovenia, Croatia, Serbia, Bulgaria): A Multicenter, Observational, Cross-Sectional Study
AuthorSanja Klobučar Majanović
AuthorAndrej Janež
AuthorIvaylo Lefterov
AuthorSanja Tasić
AuthorTatjana Cikač
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
INTRODUCTION: Recent large randomized controlled trials highlighted the clinical significance of hypoglycemic episodes in the treatment of diabetes. The present survey was conducted to provide information from real-life practice on the incidence of hypoglycemia in type 2 diabetic patients treated with sulfonylureas. METHODS: This multicenter, observational, cross-sectional study collected data on incidence of side effects of sulfonylurea-based therapy in type 2 diabetic patients in four countries of the Balkan region (Slovenia, Croatia, Serbia, Bulgaria) from October 2014 to June 2015. RESULTS: Of the 608 who participated in the study, 573 patients (mean age 67.2 years, mean body mass index 29.9 kg/m2) met the inclusion/exclusion criteria. More than 90% of the patients were treated with the newer generation sulfonylureas- gliclazide or glimepiride-either as monotherapy or as dual therapy in combination with metformin. In total, 210 patients (36.6%) reported hypoglycemic episode(s) in the last 6 months. Mild episodes were reported by 132 patients (62.8%), moderate by 66 (31.2%), severe by 8 patients (4.0%), and very severe by 4 patients (2%), respectively. Overall, 171 patients (28.2%) reported body weight increase during the previous year. The mean reported body weight gain in this group of patients was 4.2 kg (SD 2.7, median 3). Among them, 68.1% gained less than 5 kg, 25.0% gained 5-9 kg, and the rest gained more than 10 kg. CONCLUSION: Although newer generation sulfonylureas are generally considered safe in terms of hypoglycemia, our data indicates their use is associated with substantial risk of hypoglycemia and weight gain. Clinicians should be mindful of these findings when prescribing SUs and inform patients about the risk of hypoglycemia.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleDiabetes Therapy
Numberingvol. 8, no. 4, pp. 929-940
p-ISSN1869-6953
DOIhttps://doi.org/10.1007/s13300-017-0288-x
URN:NBNurn:nbn:hr:184:831778
Publication2017
Document URLhttp://bib.irb.hr/929968
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2022-03-11 15:20:00