Access restricted to higher education institution's students and staff
undergraduate thesis
Teratogeni učinci antimikrobnih lijekova

Maja Ivančić (2016)
Metadata
TitleTeratogeni učinci antimikrobnih lijekova
AuthorMaja Ivančić
Mentor(s)Jasenka Mršić-Pelčić (thesis advisor)
Abstract
Antimikrobni lijekovi su jedni od najčešće propisivanih lijekova u suvremenoj medicini. Većina antimikrobnih lijekova dobro prelazi placentarnu barijeru i sigurna je za majku i dijete. Međutim, dio lijekova ove skupine iskazuje štetno tzv. teratogeno djelovanje na plod, te im je zabranjena primjena u trudnoći. Pojam teratogenost označuje skup pojava i malformacija koje nastaju u određenom stadiju prenatalnog razvoja. Teratogeni učinak nekog lijeka je zapravo oštećenje samog embrija i to u trenutku organogeneze koja se smatra najkritičnijim razdobljem razvoja. Vrsta malformacija ovisi o tome koji je organ najosjetljiviji za vrijeme izloženosti teratogenu. Najčešće su pogođeni središnji živčani sustav, srce, mozak, uši i genitalni sustav. U ovom završnom radu učinjen je pregled teratogenih učinaka najčešće korištenih antimikrobnih lijekova. Postoji određeni broj antimikrobnih lijekova za koje je dokazan transplacentarni prijelaz i teratogeno djelovanje te ih se ne smije primjenjivati u trudnoći. Većina antimikrobnih lijekova su sigurni za primjenu u trudnoći te ne pokazuju rizik štetnog djelovanja na plod.
Keywordspregnancy teratogenicity malformations antimicrobial drugs
Committee MembersKristina Pilipović (committee chairperson)
Jasenka Mršić-Pelčić (committee member)
Dinko Vitezić (committee member)
GranterSveučilište u Rijeci
Medicinski fakultet
Lower level organizational unitsKatedra za farmakologiju
PlaceRijeka
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Pharmacology and Toxicology
Study programme typeuniversity
Study levelundergraduate
Study programmeStudy of Sanitary Engineering
Academic title abbreviationuniv. bacc. sanit. ing.
Genreundergraduate thesis
Language Croatian
Defense date2016-09-21
Parallel abstract (English)
Antimicrobials are one of the most usually prescribed medications in modern medicine. Most antimicrobials good crosses placental barrier and is safe for mother and child. However, part of this group of drugs is expressed the so-called adverse teratogenic effects on the fetus and they are barred from use in pregnancy. The term teratogenicity covers a group of phenomena and malformations created in a prenatal developmental stage. Teratogenic effect stands for embryo harming in a moment of organogenesis that is considered to be the most sensitive period of a development. Organ with the highest level of sensitivity during the exposure to teratogenic effect defines the type of malformation. Central nervous system, heart, brain, ears and genital system are most frequently harmed. In this final work was made an overview of the teratogenic effects of the most frequently used antimicrobial drugs. Transplacental transmission and teratogenic effect has been proven for a certain number of antimicrobial drugs which should not be used during pregnancy. The majority of antimicrobial drugs can be used safely during pregnancy without doing any harm to the baby
Parallel keywords (Croatian)trudnoća teratogenost malformacije antimikrobni lijekovi
Resource typetext
Access conditionAccess restricted to higher education institution's students and staff
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:468304
CommitterBosa Licul