prikaz prve stranice dokumenta Recurrences in stage II rectal carcinoma after curative resection alone: from the viewpoint of angiogenesis
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Scientific paper - Original scientific paper
Recurrences in stage II rectal carcinoma after curative resection alone: from the viewpoint of angiogenesis
World Journal of Surgical Oncology, 14 (2016), 1; 122. https://doi.org/10.1186/s12957-016-0877-6
Martinović, Željko; Kovač, Dražen; Martinović, Cvita

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Martinović, Ž., Kovač, D. & Martinović, C. (2016). Recurrences in stage II rectal carcinoma after curative resection alone: from the viewpoint of angiogenesis. World Journal of Surgical Oncology, 14. (1). doi: 10.1186/s12957-016-0877-6

Martinović, Željko, et al. "Recurrences in stage II rectal carcinoma after curative resection alone: from the viewpoint of angiogenesis." World Journal of Surgical Oncology, vol. 14, no. 1, 2016. https://doi.org/10.1186/s12957-016-0877-6

Martinović, Željko, Dražen Kovač and Cvita Martinović. "Recurrences in stage II rectal carcinoma after curative resection alone: from the viewpoint of angiogenesis." World Journal of Surgical Oncology 14, no. 1 (2016). https://doi.org/10.1186/s12957-016-0877-6

Martinović, Ž., Kovač, D. and Martinović, C. (2016) 'Recurrences in stage II rectal carcinoma after curative resection alone: from the viewpoint of angiogenesis', World Journal of Surgical Oncology, 14(1). doi: 10.1186/s12957-016-0877-6

Martinović Ž, Kovač D, Martinović C. Recurrences in stage II rectal carcinoma after curative resection alone: from the viewpoint of angiogenesis. World Journal of Surgical Oncology [Internet]. 2016 [cited 2025 April 09];14(1). doi: 10.1186/s12957-016-0877-6

Ž. Martinović, D. Kovač and C. Martinović, "Recurrences in stage II rectal carcinoma after curative resection alone: from the viewpoint of angiogenesis", World Journal of Surgical Oncology, vol. 14, no. 1, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:960229. [Accessed: 09 April 2025]

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Metadata
Title (english)Recurrences in stage II rectal carcinoma after curative resection alone: from the viewpoint of angiogenesis
AuthorŽeljko Martinović
AuthorDražen Kovač
AuthorCvita Martinović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Abstract Background: Angiogenesis plays a pivotal role in malignant tumor progression. The count of blood microvessels of the tumor has been recognized as an indicator of malignant potential of the tumors and provides the ability to predict tumors recurrence. The role endoglin in the Dukes B rectal cancer is still unexplored. The aims of this study were to examine immunohistochemical expression of endoglin in resected rectal cancer and investigate the relationship of tumor recurrence and... More other clinicopathological variables to the endoglin-assessed microvessel density of the tumor tissue and distal resection margins. Methods: The study included 95 primary rectal adenocarcinomas, corresponding to 95 distal and 95 proximal resection margin specimens from surgical resection samples. Tumor specimens were paraffin embedded, and immunohistochemical staining for the CD105 endothelial antigen was performed to count CD105-MVD. For exact measurement of the CD105-MVD used, a computer-integrated system Alphelys Spot Browser 2 was used. Results: The MVD was significantly higher in the tumor samples compared with the distal resection margins (p < 0.0001) and the proximal resection margins (p < 0.0001). There was no significant difference in the MVD between distal and proximal resection margins (p = 0.147). The type of surgical resection was a significant factor for determining the recurrence of tumors (p = 0.0104). There was no significant effect of patients’ age, gender, tumor location, grade of differentiation, histological tumor type, and the size and depth of tumor invasion on the recurrence of the tumor. The recurrence rate was significantly higher in the low CD105-MVD group of patients than in the high CD105-MVD group of patients (log rank test, p = 0.0406). Result of the multivariate analysis showed that the type of surgery (p = 0.0086), MVD tumors (p = 0.0385), and MVD of proximal resection margin (p = 0.0218) were the independent prognostic factors for the recurrent tumors. Conclusions: CD105-assessed MVD could help to identify patients with more aggressive disease and increased risk of developing tumor recurrence after surgical treatment in stage II rectal cancer (RC) Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleWorld Journal of Surgical Oncology
Numberingvol. 14, no. 1, 122
e-ISSN1477-7819
DOIhttps://doi.org/10.1186/s12957-016-0877-6
URN:NBNurn:nbn:hr:184:960229
Publication2016
Document URLhttp://wjso.biomedcentral.com/articles/10.1186/s12957-016-0877-6
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-03-07 11:52:27
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