Autoimmune thyroid disease in which the patient's immune system attacks and destroys its own cells. Autoimmune thyroiditis is also known as Hashimoto's thyroiditis is a chronic inflammatory disease of the thyroid is caused by antibodies that attack and destroy the cells of the thyroid. It is a progressive disease that causes a lack of thyroid hormone or hypothyroidism. He presents himself with a number of different symptoms making diagnosis difficult. This disease can occur at any age, but is most often present in middle-aged women. The most common symptoms are fatigue, depression, excessive sleepiness, constipation, weight gain, dry and rough skin. The symptoms become more obvious as the condition worsens, the majority of complaints are related to a slowing metabolism. After proper diagnosis treatment is carried out replacement therapy with synthetic levotirokisnom.Graves (Basedowljeva) disease is an autoimmune disease that is clinically reflected diffusely enlarged thyroid hyperfunction. The disease is the third of the patients associated with infiltrative ophthalmopathy, and in some cases with infiltrative dermopathy. Hyperthyroidism is the most common feature of Graves' disease. The result is the creation of antibodies (TRAK) which is in the thyroid binding to membrane receptors for TSH. In this way activating the receptor, and then is reacted as a cell that is acted on her TSH and T4 is released into the circulation. After diagnosis, treatment may be medication, radioactive iodine or surgery. A common feature of autoimmune thyroid disease include immune reactivity with specific antigens directed thyroid TSH receptor, thyroid peroxidase (TPO) and thyroglobulin (Tg). Autoimmune response including humoral and cellular activity. Basically the treatment of autoimmune thyroid disease, it is important to time to diagnose and attempt to remove the causes that are often associated with lifestyle and spend treatment depending on your symptoms and functional status (hyper / hypothyroidism).