Access restricted to higher education institution's students and staff
master's thesis
Autoimune bolesti štitnjače

Lorena Vuleta (2015)
Metadata
TitleAutoimune bolesti štitnjače
AuthorLorena Vuleta
Mentor(s)Sanja Klobučar Majanović (thesis advisor)
Abstract
Autoimune bolesti štitnjače su bolesti u kojima pacijentov imunološki sustav napada i oštećuje vlastite stanice. Autoimuni tireoiditis također poznat i kao Hashimotov tireoiditis je kronična upalna bolest štitnjače uzrokovana antitijelima koja napadaju i uništavaju stanice štitnjače. To je progresivna bolest koja uzrokuje manjak hormona štitnjače odnosno hipotireozu. Predstavlja se s različitim nizom simptoma što otežava postavljanje dijagnoze. Ova bolest se može pojaviti u bilo kojoj dobi, ali najčešće je prisutna kod žena srednje dobi. Najčešći simptomi su umor, depresija, pretjerana pospanost, opstipacija, debljanje i suha i gruba koža. Simptomi postaju sve očitiji kako se stanje pogoršava, a većina pritužbi se odnosi na usporenje metabolizma. Nakon pravilno postavljene dijagnoze liječenje se provodi nadomjesnom terapijom sintetskim levotirokisnom. Gravesova (Basedowljeva) bolest je autoimuna bolest koja se klinički očituje hiperfunkcijom difuzno povećane štitnjače. Bolest je u trećine pacijenata povezana s infiltrativnom oftalmopatijom, a u nekim slučajevima i s infiltrativnom dermopatijom potkoljenice. Hipertireoza je najčešća značajka Gravesove bolesti. Posljedica je stvaranja protutijela (TRAK) koja se u štitnjači vežu na membranske receptore za TSH. Na taj način se aktivira receptor i onda stanica reagira kao da je na nju djelovao TSH te otpušta T4 u cirkulaciju. Nakon postavljanja dijagnoze terapija može biti medikamentna, radioaktivnim jodom ili kirurška. Zajedničko obilježje autoimunih bolesti štitnjače uključuju imunološku reaktivnost s određenim antigenima štitnjače usmjerenu na TSH receptor, peroksidazu štitnjače (TPO) i tireoglobulin (Tg). Autoimuni odgovor uključuje humoralnu i staničnu aktivnost. U osnovi liječenja autoimunih bolesti štitnjače bitno je na vrijeme postaviti dijagnozu, nastojati otkloniti uzroke koji su često povezani sa životnim stilom te provesti liječenje ovisno o simptomima, odnosno funkcionalnom statusu (hiper/hipotireoza).
KeywordsThyroid Diseases Hashimoto Disease Graves Disease
GranterSveučilište u Rijeci
Medicinski fakultet
Lower level organizational unitsKatedra za internu medicinu
PlaceRijeka
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmeMedicine
Academic title abbreviationdr. med.
Genremaster's thesis
Language Croatian
Defense date2015
Parallel abstract (English)
Autoimmune thyroid disease in which the patient's immune system attacks and destroys its own cells. Autoimmune thyroiditis is also known as Hashimoto's thyroiditis is a chronic inflammatory disease of the thyroid is caused by antibodies that attack and destroy the cells of the thyroid. It is a progressive disease that causes a lack of thyroid hormone or hypothyroidism. He presents himself with a number of different symptoms making diagnosis difficult. This disease can occur at any age, but is most often present in middle-aged women. The most common symptoms are fatigue, depression, excessive sleepiness, constipation, weight gain, dry and rough skin. The symptoms become more obvious as the condition worsens, the majority of complaints are related to a slowing metabolism. After proper diagnosis treatment is carried out replacement therapy with synthetic levotirokisnom.Graves (Basedowljeva) disease is an autoimmune disease that is clinically reflected diffusely enlarged thyroid hyperfunction. The disease is the third of the patients associated with infiltrative ophthalmopathy, and in some cases with infiltrative dermopathy. Hyperthyroidism is the most common feature of Graves' disease. The result is the creation of antibodies (TRAK) which is in the thyroid binding to membrane receptors for TSH. In this way activating the receptor, and then is reacted as a cell that is acted on her TSH and T4 is released into the circulation. After diagnosis, treatment may be medication, radioactive iodine or surgery. A common feature of autoimmune thyroid disease include immune reactivity with specific antigens directed thyroid TSH receptor, thyroid peroxidase (TPO) and thyroglobulin (Tg). Autoimmune response including humoral and cellular activity. Basically the treatment of autoimmune thyroid disease, it is important to time to diagnose and attempt to remove the causes that are often associated with lifestyle and spend treatment depending on your symptoms and functional status (hyper / hypothyroidism).
Parallel keywords (Croatian)štitnjača autoimune bolesti Basedowljeva bolest Hashimotov tireoiditis
Resource typetext
Access conditionAccess restricted to higher education institution's students and staff
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:220790
CommitterBosa Licul