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Scientific paper - Original scientific paper
Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies
MEDICAL SCIENCE MONITOR, 24 (2018); 5084-5092. https://doi.org/10.12659/msm.909172
Boban, Marko; Peša, Vladimir; Peršić, Viktor; Žulj, Marinko; Malčić, Ivan; Beck, Natko; Včev, Aleksandar

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Boban, M., Peša, V., Peršić, V., Žulj, M., Malčić, I., Beck, N. & Včev, A. (2018). Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies. MEDICAL SCIENCE MONITOR, 24., 5084-5092. doi: 10.12659/msm.909172

Boban, Marko, et al. "Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies." MEDICAL SCIENCE MONITOR, vol. 24, 2018, pp. 5084-5092. https://doi.org/10.12659/msm.909172

Boban, Marko, Vladimir Peša, Viktor Peršić, Marinko Žulj, Ivan Malčić, Natko Beck and Aleksandar Včev. "Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies." MEDICAL SCIENCE MONITOR 24 (2018): 5084-5092. https://doi.org/10.12659/msm.909172

Boban, M., et al. (2018) 'Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies', MEDICAL SCIENCE MONITOR, 24, pp. 5084-5092. doi: 10.12659/msm.909172

Boban M, Peša V, Peršić V, Žulj M, Malčić I, Beck N, and sur.. Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies. MEDICAL SCIENCE MONITOR [Internet]. 2018 [cited 2024 November 23];24:5084-5092. doi: 10.12659/msm.909172

M. Boban, et al., "Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies", MEDICAL SCIENCE MONITOR, vol. 24, pp. 5084-5092, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:699388. [Accessed: 23 November 2024]

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Title (english)Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies
AuthorMarko Boban
AuthorVladimir Peša
AuthorViktor Peršić
AuthorMarinko Žulj
AuthorIvan Malčić
AuthorNatko Beck
AuthorAleksandar Včev
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Rehabilitatiom Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background: Dilatation and other infrastructural rearrangements of the left ventricle are connected with poor prognosis. The aim of our study was to analyze the overlapping phenotypes and dilatation of the ventricle on impairment of systolic function and existence of late gadolinium enhancement (LGE). Material/Methods: Consecutive sample of cases with dilated left ventricle due to non-ischemic cardiomyopathy and healthy controls were included from our cardiac magnetic resonance imaging (CMR) database for a period of 3 years (n=1551 exams). Results: The study included 127 patients ; 30 (23.6%) with dilated cardiomyopathy (DCM) ; 30 (23.6%) with left ventricular non-compaction (LVNC) ; 13 (10.2%) with hypertrophic cardiomyopathy (HCM), and 50 (39.4%) controls. Overlapping phenotypes were found in 48 (37.8%) of the studied cases. Odds for impairment of systolic function in connection with overlapping phenotypes were estimated at 7.8 (95%-CI: 3.4-17.6), (p<0.001). There were significant differences in geometric parameters for patients with overlapping phenotypes vs. controls, as follows: left ventricle end- diastolic dimension(LVEDD) = 6.6 +/- 0.8 vs. 5.6 +/- 1.0 cm (p<0.001) ; left ventricular ejection fraction (LVEF) = 39.3 +/- 14.0 vs. 52.1 +/- 16.1 (p<0.001) ; and existence of LGE 36 (75.0%) vs. 21 (26.6%), (p<0.001), respectively. Overlapping phenotypes correlated with LVEDD (Spearman's-Rho-CC) = 0.521, p<0.001 ; LVEF (Rho-CC) = -0.447, p<0.001 and LGE (Rho-CC)= 0.472, p<0.001. Conclusions: This study found there are many patients with overlapping phenotypes among NICMPs with dilated left ventricles. Overlapping phenotype was associated with greater LVEDD, lesser systolic function, and commonly existing LGE, which all impose increased cardiovascular risk. Linear midventricular LGE stripe was the most powerfully connected with loss of systolic function.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMEDICAL SCIENCE MONITOR
Numberingvol. 24, pp. 5084-5092
p-ISSN1643-3750
DOIhttps://doi.org/10.12659/msm.909172
URN:NBNurn:nbn:hr:184:699388
Publication2018
Document URLhttp://bib.irb.hr/1049082
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-03-01 16:57:41