prikaz prve stranice dokumenta NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.
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Scientific paper - Original scientific paper
NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.
European Journal of Immunology, 47 (2017), 4; 692-703. https://doi.org/10.1002/eji.201646756
Diab, M.; Glasner, A.; Issacson, B.; Bar-On, Yotam; Drori, Y.; Yamin, R.; Duev-Cohen, A.; Danziger, O.; Zamostiano, R.; Mandelboim, M.; Jonjić, Stipan; Bacharach, E.; Mandelboim, O.

Cite this document

Diab, M., Glasner, A., Issacson, B., Bar On, Y., Drori, Y., Yamin, R. ... Mandelboim, O. (2017). NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.. European Journal of Immunology, 47. (4), 692-703. doi: 10.1002/eji.201646756

Diab, M., et al. "NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.." European Journal of Immunology, vol. 47, no. 4, 2017, pp. 692-703. https://doi.org/10.1002/eji.201646756

Diab, M., A. Glasner, B. Issacson, Yotam Bar On, Y. Drori, R. Yamin, A. Duev Cohen, et al. "NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.." European Journal of Immunology 47, no. 4 (2017): 692-703. https://doi.org/10.1002/eji.201646756

Diab, M., et al. (2017) 'NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.', European Journal of Immunology, 47(4), pp. 692-703. doi: 10.1002/eji.201646756

Diab M, Glasner A, Issacson B, Bar On Y, Drori Y, Yamin R, and sur.. NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.. European Journal of Immunology [Internet]. 2017 [cited 2024 July 11];47(4):692-703. doi: 10.1002/eji.201646756

M. Diab, et al., "NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.", European Journal of Immunology, vol. 47, no. 4, pp. 692-703, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:535729. [Accessed: 11 July 2024]

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Metadata
Title (english)NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.
AuthorM. Diab
AuthorA. Glasner
AuthorB. Issacson
AuthorYotam Bar-On
AuthorY. Drori
AuthorR. Yamin
AuthorA. Duev-Cohen
AuthorO. Danziger
AuthorR. Zamostiano
AuthorM. Mandelboim
AuthorStipan Jonjić
AuthorE. Bacharach
AuthorO. Mandelboim
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Natural killer (NK) cells are capable of killing various pathogens upon stimulation of activating receptors. Human metapneumovirus (HMPV) is a respiratory virus, which was discovered in 2001 and is responsible for acute respiratory tract infection in infants and children worldwide. HMPV infection is very common, infecting around 70% of all children under the age of five. Under immune suppressive conditions, HMPV infection can be fatal. Not much is known on how NK cells respond to HMPV. In this study, using reporter assays and NK-cell cytotoxicity assays performed with human and mouse NK cells, we demonstrated that the NKp46-activating receptor and its mouse orthologue Ncr1, both members of the natural cytotoxicity receptor (NCR) family, recognized an unknown ligand expressed by HMPV-infected human cells. We demonstrated that MHC class I is upregulated and MICA is downregulated upon HMPV infection. We also characterized mouse NK-cell phenotype in the blood and the lungs of HMPV-infected mice and found that lung NK cells are more activated and expressing NKG2D, CD43, CD27, KLRG1, and CD69 compared to blood NK cells regardless of HMPV infection. Finally, we demonstrated, using Ncr1-deficient mice, that NCR1 plays a critical role in controlling HMPV infection.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEuropean Journal of Immunology
Numberingvol. 47, no. 4, pp. 692-703
p-ISSN0014-2980
e-ISSN1521-4141
DOIhttps://doi.org/10.1002/eji.201646756
URN:NBNurn:nbn:hr:184:535729
Publication2017
ProjectNumber: 062-0621261-1263
Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Title (english): Molecular mechanisms of immune evasion by cytomegalovirus
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://bib.irb.hr/867231
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-28 14:04:15