master's thesis
Statini

Marija Fain (2016)
Sveučilište u Rijeci
Medicinski fakultet
Katedra za farmakologiju
Metadata
TitleStatini : nadmašuju li rizici prednosti?
AuthorMarija Fain
Mentor(s)Kristina Pilipović (thesis advisor)
Abstract
Statini, lijekovi za snižavanje kolesterola su nezaobilazni temelj koji se ĉesto propisuju u kliniĉkoj praksi radi prevencije i lijeĉenja kardiovaskularnih bolesti. Iako postoje brojni dokazi o utjecaju statina na snižavanje LDL i ukupnog kolesterola i dugotrajnih uĉinaka kod prevencije kardiovaskularnih bolesti, još uvijek postoje razne predrasude koje su vezane za razne uĉinke lijeĉenja statinima koji su nepoţeljni te njihovu moguću štetnost. Mehanizam djelovanja ovih lijekova je inhibicija hidroksi-metil-glutaril koenzima A reduktaze (HMG CoA), enzima znaĉajnog u procesu sinteze kolesterola. Statini svoje pozitivne uĉinke na smanjenje srĉanožilnog rizika ne ostvaruju samo tako što snizuju razinu kolesterola nego se tu radi i o nizu o kolesterolu neovisnih pleiotropnih uĉinaka. Nuspojave koje se javljaju prilikom lijeĉenja statinima su većinom blage i najĉešće ne zahtijevaju prekid lijeĉenja.
Keywordsstatins cholesterol HMG CoA side effect
Committee MembersGordana Pelčić (committee chairperson)
Jasenka Mršić-Pelčić (committee member)
Kristina Pilipović (committee member)
GranterSveučilište u Rijeci
Medicinski fakultet
Lower level organizational unitsKatedra za farmakologiju
PlaceRijeka
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Pharmacology and Toxicology
Study programme typeuniversity
Study levelgraduate
Study programmeStudy of Sanitary Engineering
Academic title abbreviationmag. sanit. ing.
Genremaster's thesis
Language Croatian
Defense date2016-07-18
Parallel abstract (English)
Statins are medications for cholesterol reduction who are foundation for prophylaxis and therapy of cardiovascular diseases. Although there are ample evidence on the effect of statins in reduction LDL and total cholesterol and long-term effects in prevention cardiovascular disease, there are still many prejudices related to various effects of statins, which are undesirable and their possible harmful effects. Their main mechanism of action is inhibition of hydroxy-methyl-glutaryl coenzyme A reductase (HMG CoA reductase), an enzyme that is important in the synthesis of cholesterol. Statins positive effects on cardiovascular risk reduction do not achieved only by lowering cholesterol levels but it works on a range of cholesterol independent pleiotropic effects. Side effects that occur during treatment with statins are mild and usually does not require discontinuation of treatment.
Parallel keywords (Croatian)statini kolesterol HMG CoA nuspojave
Resource typetext
Access conditionAccess restricted to students and staff of home institution
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:236012
CommitterBosa Licul