prikaz prve stranice dokumenta Statini
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master's thesis
Statini
nadmašuju li rizici prednosti?
2016. urn:nbn:hr:184:236012
Fain, Marija
University of Rijeka
Faculty of Medicine
Department of Pharmacology

Cite this document

Fain, M. (2016). Statini : nadmašuju li rizici prednosti? (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:236012

Fain, Marija. "Statini : nadmašuju li rizici prednosti?." Master's thesis, University of Rijeka, Faculty of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:184:236012

Fain, Marija. "Statini : nadmašuju li rizici prednosti?." Master's thesis, University of Rijeka, Faculty of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:184:236012

Fain, M. (2016). 'Statini : nadmašuju li rizici prednosti?', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 10 July 2024, https://urn.nsk.hr/urn:nbn:hr:184:236012

Fain M. Statini : nadmašuju li rizici prednosti? [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2016 [cited 2024 July 10] Available at: https://urn.nsk.hr/urn:nbn:hr:184:236012

M. Fain, "Statini : nadmašuju li rizici prednosti?", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:184:236012

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Metadata
TitleStatini : nadmašuju li rizici prednosti?
AuthorMarija Fain
MentorKristina Pilipović (mentor)
Committee memberGordana Pelčić (predsjednik povjerenstva)
Committee memberJasenka Mršić-Pelčić (član povjerenstva)
Committee memberKristina Pilipović (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Pharmacology)
Rijeka
Defense date and country2016-07-18, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Pharmacology and Toxicology
Abstract
Statini, lijekovi za snižavanje kolesterola su nezaobilazni temelj koji se ĉesto propisuju u kliniĉkoj praksi radi prevencije i lijeĉenja kardiovaskularnih bolesti. Iako postoje brojni dokazi o utjecaju statina na snižavanje LDL i ukupnog kolesterola i dugotrajnih uĉinaka kod prevencije kardiovaskularnih bolesti, još uvijek postoje razne predrasude koje su vezane za razne uĉinke lijeĉenja statinima koji su nepoţeljni te njihovu moguću štetnost. Mehanizam djelovanja ovih lijekova je inhibicija hidroksi-metil-glutaril koenzima A reduktaze (HMG CoA), enzima znaĉajnog u procesu sinteze kolesterola. Statini svoje pozitivne uĉinke na smanjenje srĉanožilnog rizika ne ostvaruju samo tako što snizuju razinu kolesterola nego se tu radi i o nizu o kolesterolu neovisnih pleiotropnih uĉinaka. Nuspojave koje se javljaju prilikom lijeĉenja statinima su većinom blage i najĉešće ne zahtijevaju prekid lijeĉenja.
Abstract (english)
Statins are medications for cholesterol reduction who are foundation for prophylaxis and therapy of cardiovascular diseases. Although there are ample evidence on the effect of statins in reduction LDL and total cholesterol and long-term effects in prevention cardiovascular disease, there are still many prejudices related to various effects of statins, which are undesirable and their possible harmful effects. Their main mechanism of action is inhibition of hydroxy-methyl-glutaryl coenzyme A reductase (HMG CoA reductase), an enzyme that is important in the synthesis of cholesterol. Statins positive effects on cardiovascular risk reduction do not achieved only by lowering cholesterol levels but it works on a range of cholesterol independent pleiotropic effects. Side effects that occur during treatment with statins are mild and usually does not require discontinuation of treatment.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:236012
Study programmeTitle: Study of Sanitary Engineering
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra sanitarnog inženjerstva (magistar/magistra sanitarnog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2016-10-28 09:34:18