prikaz prve stranice dokumenta Immunological characteristics of schizophrenia
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Scientific paper - Conference paper
Immunological characteristics of schizophrenia
Psychiatria Danubina. Supplement, 30 (2018), S4; S180-S187. urn:nbn:hr:184:903803
Rubeša, Gordana; Gudelj, Lea; Dolores, Makovac

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Rubeša, G., Gudelj, L. & Dolores, M. (2018). Immunological characteristics of schizophrenia. Psychiatria Danubina. Supplement, 30. (S4), S180-S187. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:903803

Rubeša, Gordana, et al. "Immunological characteristics of schizophrenia." Psychiatria Danubina. Supplement, vol. 30, no. S4, 2018, pp. S180-S187. https://urn.nsk.hr/urn:nbn:hr:184:903803

Rubeša, Gordana, Lea Gudelj and Makovac Dolores. "Immunological characteristics of schizophrenia." Psychiatria Danubina. Supplement 30, no. S4 (2018): S180-S187. https://urn.nsk.hr/urn:nbn:hr:184:903803

Rubeša, G., Gudelj, L. and Dolores, M. (2018) 'Immunological characteristics of schizophrenia', Psychiatria Danubina. Supplement, 30(S4), pp. S180-S187. Available at: https://urn.nsk.hr/urn:nbn:hr:184:903803 (Accessed 23 November 2024)

Rubeša G, Gudelj L, Dolores M. Immunological characteristics of schizophrenia. Psychiatria Danubina. Supplement [Internet]. 2018 [cited 2024 November 23];30(S4):S180-S187. Available at: https://urn.nsk.hr/urn:nbn:hr:184:903803

G. Rubeša, L. Gudelj and M. Dolores, "Immunological characteristics of schizophrenia", Psychiatria Danubina. Supplement, vol. 30, no. S4, pp. S180-S187, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:903803. [Accessed: 23 November 2024]

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Metadata
Title (english)Immunological characteristics of schizophrenia
AuthorGordana Rubeša
AuthorLea Gudelj
AuthorMakovac Dolores
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
There are many theories about the etiology of schizophrenia. This paper presents the assumptions and latest findings about many immunological characteristics of schizophrenia. According to the neuroimunological theory, this disorder is due to neuroimunological disbalance, increased microglial activity and increased levels of proinflammatory cytokines. Studies have found that intrauterine infections in pregnant women have an effect on the fetal brain development, and that infections with rubella, measles, herpes virus, and toxoplasma are associeted with schizophrenia onset in adult life. In the first episode of schizophrenia and during exacerbation in the serum of the patient, an increased level of proinflammatory cytokines was found. Increased levels of IL-6, TNF-α and IL-1β, and decreased levels of anti-inflammatory cytokines, Il-10. Interleukin 6 levels increase in the psychotic phase of the disease and normalize after the antipsychotic drug treatment. Increased level of IL-6 is associated with severe cognitive impairment and it is more common with patients who had been without adequate treatment for a long time and patients with therapeutic- resistant schizophrenia. Treatment of schizophrenia could be improved by the introduction of anti-inflammatory drug in the therapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Conference paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePsychiatria Danubina. Supplement
Numberingvol. 30, no. S4, pp. S180-S187
p-ISSN1332-1366
URN:NBNurn:nbn:hr:184:903803
Publication2018
Document URLhttp://bib.irb.hr/953746
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-02-21 13:44:34