prikaz prve stranice dokumenta Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials
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Scientific paper - Original scientific paper
Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials
Journal of Clinical Lipidology, 12 (2018), 3; 801-809. https://doi.org/10.1016/j.jacl.2018.01.008
Sahebkar, Amirhossein; Simental-Mendía, Luis E.; Mikhailidis, Dimitri P.; Pirro, Matteo; Banach, Maciej; Sirtori, Cesare R.; Ruscica, Massimiliano; Reiner, Željko

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Sahebkar, A., Simental Mendía, L. E., Mikhailidis, D. P., Pirro, M., Banach, M., Sirtori, C. R. ... Reiner, Ž. (2018). Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials. Journal of Clinical Lipidology, 12. (3), 801-809. doi: 10.1016/j.jacl.2018.01.008

Sahebkar, Amirhossein, et al. "Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials." Journal of Clinical Lipidology, vol. 12, no. 3, 2018, pp. 801-809. https://doi.org/10.1016/j.jacl.2018.01.008

Sahebkar, Amirhossein, Luis E. Simental Mendía, Dimitri P. Mikhailidis, Matteo Pirro, Maciej Banach, Cesare R. Sirtori, Massimiliano Ruscica and Željko Reiner. "Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials." Journal of Clinical Lipidology 12, no. 3 (2018): 801-809. https://doi.org/10.1016/j.jacl.2018.01.008

Sahebkar, A., et al. (2018) 'Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials', Journal of Clinical Lipidology, 12(3), pp. 801-809. doi: 10.1016/j.jacl.2018.01.008

Sahebkar A, Simental Mendía LE, Mikhailidis DP, Pirro M, Banach M, Sirtori CR, and sur.. Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials. Journal of Clinical Lipidology [Internet]. 2018 [cited 2025 January 23];12(3):801-809. doi: 10.1016/j.jacl.2018.01.008

A. Sahebkar, et al., "Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials", Journal of Clinical Lipidology, vol. 12, no. 3, pp. 801-809, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:802520. [Accessed: 23 January 2025]

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Metadata
Title (english)Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials
AuthorAmirhossein Sahebkar
AuthorLuis E. Simental-Mendía
AuthorDimitri P. Mikhailidis
AuthorMatteo Pirro
AuthorMaciej Banach
AuthorCesare R. Sirtori
AuthorMassimiliano Ruscica
AuthorŽeljko Reiner
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Statins are well-established low- density lipoprotein cholesterol lowering drugs. Elevated apolipoprotein CIII (Apo CIII) levels are associated with elevated triglyceride-rich particles, which are also considered to be a possible risk factor for cardiovascular disease. OBJECTIVE: The aim of this meta-analysis of randomized placebo-controlled clinical trials was to assess the effect of statins on Apo CIII concentrations. METHODS: Randomized placebo-controlled trials investigating the impact of statin treatment on cholesterol lowering that include lipoprotein measurement were searched in PubMed, MEDLINE, Scopus, Web of Science, and Google Scholar databases (up to July 31, 2017). A random- effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on Apo CIII concentrations. RESULTS: This meta-analysis of data from 6 randomized placebo-controlled clinical trials (10 statin arms) involving 802 subjects showed that statin therapy significantly decreased circulating Apo CIII concentrations (weighted mean difference [WMD]: -2.71, 95% confidence interval [CI]: -3.74 to -1.68, P < .001 ; I-2: 73.83%). The effect size was robust in the leave-one-out sensitivity analysis and not driven by any single study. Subgroup analysis showed a reduction of Apo CIII concentrations by atorvastatin (WMD: -4.74, 95% CI:-3.74 to -1.68, P =.002 ; I-2: 84.02%), rosuvastatin (WMD: -2.68, 95% CI: -4.52 to-0.84, P = .004 ; I-2: 0%), and lovastatin (WMD: -1.64, 95% CI: -2.22 to -1.07, P < .001 ; I-2: 0%). CONCLUSION: This meta-analysis suggests that statin treatment significantly reduces plasma Apo CIII levels. (C) 2018 National Lipid Association. All rights reserved
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Clinical Lipidology
Numberingvol. 12, no. 3, pp. 801-809
p-ISSN1933-2874
DOIhttps://doi.org/10.1016/j.jacl.2018.01.008
URN:NBNurn:nbn:hr:184:802520
Publication2018
Document URLhttp://bib.irb.hr/1050169
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-02-17 17:51:21