prikaz prve stranice dokumenta Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study
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Scientific paper - Conference paper
Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study
Croatian medical journal, 60 (2019), 3; 227-236. urn:nbn:hr:184:867218
Hudetz, Damir; Borić, Igor; Rod, Eduard; Jelec, Željko; Kunovac, Barbara; Polašek, Ozren; Vrdoljak, Trpimir; Plečko, Mihovil; Skelin, Andrea; Polančec, Denis; Zenić, Lucija; Primorac, Dragan

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Hudetz, D., Borić, I., Rod, E., Jelec, Ž., Kunovac, B., Polašek, O. ... Primorac, D. (2019). Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study. Croatian medical journal, 60. (3), 227-236. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:867218

Hudetz, Damir, et al. "Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study." Croatian medical journal, vol. 60, no. 3, 2019, pp. 227-236. https://urn.nsk.hr/urn:nbn:hr:184:867218

Hudetz, Damir, Igor Borić, Eduard Rod, Željko Jelec, Barbara Kunovac, Ozren Polašek, Trpimir Vrdoljak, et al. "Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study." Croatian medical journal 60, no. 3 (2019): 227-236. https://urn.nsk.hr/urn:nbn:hr:184:867218

Hudetz, D., et al. (2019) 'Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study', Croatian medical journal, 60(3), pp. 227-236. Available at: https://urn.nsk.hr/urn:nbn:hr:184:867218 (Accessed 15 December 2024)

Hudetz D, Borić I, Rod E, Jelec Ž, Kunovac B, Polašek O, and sur.. Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study. Croatian medical journal [Internet]. 2019 [cited 2024 December 15];60(3):227-236. Available at: https://urn.nsk.hr/urn:nbn:hr:184:867218

D. Hudetz, et al., "Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study", Croatian medical journal, vol. 60, no. 3, pp. 227-236, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:867218. [Accessed: 15 December 2024]

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Metadata
Title (english)Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study
AuthorDamir Hudetz
AuthorIgor Borić
AuthorEduard Rod
AuthorŽeljko Jelec
AuthorBarbara Kunovac
AuthorOzren Polašek
AuthorTrpimir Vrdoljak
AuthorMihovil Plečko
AuthorAndrea Skelin
AuthorDenis Polančec
AuthorLucija Zenić
AuthorDragan Primorac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Aim To analyze clinical and functional effects of intra-articular injection of autologous micro-fragmented lipoaspirate (MLA) in patients with late stage knee osteoarthritis (KOA). Secondary aims included classifying cell types contributing to the treatment effect, performing detailed MRI-based classification of KOA, and elucidating the predictors for functional outcomes. Methods This prospective, non-randomized study was conducted from June 2016 to February 2018 and enrolled 20 patients with late stage symptomatic KOA (Kellgren Lawrence grade III, n = 4 ; and IV, n = 16) who received an intra- articular injection of autologous MLA in the index knee joint. At baseline radiological KOA grade and MRI were assessed in order to classify the morphology of KOA changes. Stromal vascular fraction cells obtained from MLA samples were stained with antibodies specific for cell surface markers. Patients were evaluated at baseline and 12-months after treatment with visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Knee Injury and Osteoarthritis Outcome Score (KOOS). Results Three patients (15%) received a total knee replacement and were not followed up completely. Seventeen patients (85%) showed a substantial pattern of KOOS and WOMAC improvement, significant in all accounts. KOOS score improved from 46 to 176% when compared with baseline, WOMAC decreased from 40 to 45%, while VAS rating decreased from 54% to 82% (all P values were < 0.001). MLA contained endothelial progenitor cells, pericytes, and supra-adventitial adipose stromal cells as most abundant cell phenotypes. Conclusion This study is among the first to show a positive effect of MLA on patients with late stages KOA.
Keywords (english)
Languageenglish
Publication typeScientific paper - Conference paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian medical journal
Numberingvol. 60, no. 3, pp. 227-236
p-ISSN0353-9504
URN:NBNurn:nbn:hr:184:867218
Publication2019
Document URLhttp://bib.irb.hr/1049705
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-02-17 14:01:59