prikaz prve stranice dokumenta Effect of omega-3 supplements on plasma apolipoprotein C-III concentrations: a systematic review and meta-analysis of randomized controlled trials
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Scientific paper - Original scientific paper
Effect of omega-3 supplements on plasma apolipoprotein C-III concentrations: a systematic review and meta-analysis of randomized controlled trials
Annals of Medicine, 50 (2018), 7; 565-575. https://doi.org/10.1080/07853890.2018.1511919
Sahebkar, Amirhossein; Simental-Mendía, Luis E.; Mikhailidis, Dimitri P.; Pirro, Matteo; Banach, Maciej; Sirtori, Cesare R.; Reiner, Željko

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Sahebkar, A., Simental Mendía, L. E., Mikhailidis, D. P., Pirro, M., Banach, M., Sirtori, C. R. & Reiner, Ž. (2018). Effect of omega-3 supplements on plasma apolipoprotein C-III concentrations: a systematic review and meta-analysis of randomized controlled trials. Annals of Medicine, 50. (7), 565-575. doi: 10.1080/07853890.2018.1511919

Sahebkar, Amirhossein, et al. "Effect of omega-3 supplements on plasma apolipoprotein C-III concentrations: a systematic review and meta-analysis of randomized controlled trials." Annals of Medicine, vol. 50, no. 7, 2018, pp. 565-575. https://doi.org/10.1080/07853890.2018.1511919

Sahebkar, Amirhossein, Luis E. Simental Mendía, Dimitri P. Mikhailidis, Matteo Pirro, Maciej Banach, Cesare R. Sirtori and Željko Reiner. "Effect of omega-3 supplements on plasma apolipoprotein C-III concentrations: a systematic review and meta-analysis of randomized controlled trials." Annals of Medicine 50, no. 7 (2018): 565-575. https://doi.org/10.1080/07853890.2018.1511919

Sahebkar, A., et al. (2018) 'Effect of omega-3 supplements on plasma apolipoprotein C-III concentrations: a systematic review and meta-analysis of randomized controlled trials', Annals of Medicine, 50(7), pp. 565-575. doi: 10.1080/07853890.2018.1511919

Sahebkar A, Simental Mendía LE, Mikhailidis DP, Pirro M, Banach M, Sirtori CR, and sur.. Effect of omega-3 supplements on plasma apolipoprotein C-III concentrations: a systematic review and meta-analysis of randomized controlled trials. Annals of Medicine [Internet]. 2018 [cited 2024 July 13];50(7):565-575. doi: 10.1080/07853890.2018.1511919

A. Sahebkar, et al., "Effect of omega-3 supplements on plasma apolipoprotein C-III concentrations: a systematic review and meta-analysis of randomized controlled trials", Annals of Medicine, vol. 50, no. 7, pp. 565-575, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:956573. [Accessed: 13 July 2024]

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Metadata
Title (english)Effect of omega-3 supplements on plasma apolipoprotein C-III concentrations: a systematic review and meta-analysis of randomized controlled trials
AuthorAmirhossein Sahebkar
AuthorLuis E. Simental-Mendía
AuthorDimitri P. Mikhailidis
AuthorMatteo Pirro
AuthorMaciej Banach
AuthorCesare R. Sirtori
AuthorŽeljko Reiner
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: Apolipoprotein C-III (apo C-III) is a key regulator of triglycerides metabolism. The aim of this meta-analysis was to assess the effect of fish omega-3 polyunsaturated fatty acids (PUFAs) on apo C-III levels.Methods: Randomized placebo-controlled trials investigating the impact of omega-3 on apo C- III levels were searched in PubMed-Medline, SCOPUS, Web of Science and Google Scholar. A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on glycemic parameters.Results: This meta-analysis comprising 2062 subjects showed a significant reduction of apo C-III concentrations following treatment with omega-3 (WMD: -22.18mg/L, 95% confidence interval: -31.61, -12.75, p<.001 ; I- 2: 88.24%). Subgroup analysis showed a significant reduction of plasma apo C-III concentrations by eicosapentaenoic acid (EPA) ethyl esters but not omega-3 carboxylic acids or omega-3 ethyl esters. There was a greater apo C-III reduction with only EPA as compared with supplements containing EPA and docosahexaenoic acid (DHA) or only DHA. A positive association between the apo C-III- lowering effect of omega-3 with baseline apo C- III concentrations and treatment duration was found.Conclusions: This meta-analysis has shown that omega-3 PUFAs might significantly decrease apo C-III.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAnnals of Medicine
Numberingvol. 50, no. 7, pp. 565-575
p-ISSN0785-3890
DOIhttps://doi.org/10.1080/07853890.2018.1511919
URN:NBNurn:nbn:hr:184:956573
Publication2018
Document URLhttp://bib.irb.hr/1050166
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-17 13:55:20