prikaz prve stranice dokumenta CYP2D6 *6/*6 genotype and drug interactions as cause of haloperidol induced extrapyramidal symptoms
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Scientific paper - Case study
CYP2D6 *6/*6 genotype and drug interactions as cause of haloperidol induced extrapyramidal symptoms
Pharmacogenomics, 17 (2016), 13; 1385-1389. https://doi.org/10.2217/pgs-2016-0069
Šimić, Iveta; Potočnjak, Ines; Kraljičković, Iva; Stanić Benić, Mirjana; Čegec, Ivana; Juričić Nahal, Danica; Ganoci, Lana; Božina, Nada

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Šimić, I., Potočnjak, I., Kraljičković, I., Stanić Benić, M., Čegec, I., Juričić Nahal, D. ... Božina, N. (2016). CYP2D6 *6/*6 genotype and drug interactions as cause of haloperidol induced extrapyramidal symptoms. Pharmacogenomics, 17. (13), 1385-1389. doi: 10.2217/pgs-2016-0069

Šimić, Iveta, et al. "CYP2D6 *6/*6 genotype and drug interactions as cause of haloperidol induced extrapyramidal symptoms." Pharmacogenomics, vol. 17, no. 13, 2016, pp. 1385-1389. https://doi.org/10.2217/pgs-2016-0069

Šimić, Iveta, Ines Potočnjak, Iva Kraljičković, Mirjana Stanić Benić, Ivana Čegec, Danica Juričić Nahal, Lana Ganoci and Nada Božina. "CYP2D6 *6/*6 genotype and drug interactions as cause of haloperidol induced extrapyramidal symptoms." Pharmacogenomics 17, no. 13 (2016): 1385-1389. https://doi.org/10.2217/pgs-2016-0069

Šimić, I., et al. (2016) 'CYP2D6 *6/*6 genotype and drug interactions as cause of haloperidol induced extrapyramidal symptoms', Pharmacogenomics, 17(13), pp. 1385-1389. doi: 10.2217/pgs-2016-0069

Šimić I, Potočnjak I, Kraljičković I, Stanić Benić M, Čegec I, Juričić Nahal D, and sur.. CYP2D6 *6/*6 genotype and drug interactions as cause of haloperidol induced extrapyramidal symptoms. Pharmacogenomics [Internet]. 2016 [cited 2024 December 26];17(13):1385-1389. doi: 10.2217/pgs-2016-0069

I. Šimić, et al., "CYP2D6 *6/*6 genotype and drug interactions as cause of haloperidol induced extrapyramidal symptoms", Pharmacogenomics, vol. 17, no. 13, pp. 1385-1389, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:199971. [Accessed: 26 December 2024]

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Metadata
Title (english)CYP2D6 *6/*6 genotype and drug interactions as cause of haloperidol induced extrapyramidal symptoms
AuthorIveta Šimić
MBZ: 210433
AuthorInes Potočnjak
MBZ: 361174
AuthorIva Kraljičković
AuthorMirjana Stanić Benić
AuthorIvana Čegec
AuthorDanica Juričić Nahal
AuthorLana Ganoci
MBZ: 382855
AuthorNada Božina
MBZ: 91773
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
A 66-year-old male Caucasian, received 1 mg of haloperidol orally and rapidly developed severe iatrogenic extrapyramidal symptoms. Treatment was immediately discontinued, and the side effects resolved. Haloperidol is mainly metabolized by Phase I CYP2D6 and to the lesser extent by CYP3A4 and by Phase II UGT2B7 enzymes. Genotyping was performed revealing CYP2D6*6/*6, CYP3A4*1/*1, and UGT2B7 -161 C/T genotypes, implicating poor, extensive and intermediate metabolism, respectively. Of the CYPs, haloperidol is metabolized by CYP2D6 and CYP3A4 primarily. It was the introduction of ciprofloxacin which was a trigger for the development of adverse drug reaction due to inhibition of CYP3A4, which was in presented patient main metabolic pathway for haloperidol since he was CYP2D6 poor metabolizer. Presented case report highlights the importance of genotyping. Pharmacogenetics testing should be considered when drug toxicity is suspected, polymorphic metabolic pathways used and drugs concomitantly applied.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePharmacogenomics
Numberingvol. 17, no. 13, pp. 1385-1389
p-ISSN1462-2416
DOIhttps://doi.org/10.2217/pgs-2016-0069
URN:NBNurn:nbn:hr:184:199971
Publication2016
Document URLhttp://bib.irb.hr/935703
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-02-15 11:04:49