Access restricted to higher education institution's students and staff
master's thesis
Transplantacija bubrega i utjecaj hladne ishemije na preživljenje presatka

Dominik Buljan (2016)
Metadata
TitleTransplantacija bubrega i utjecaj hladne ishemije na preživljenje presatka
AuthorDominik Buljan
Mentor(s)Dean Markić (thesis advisor)
Abstract
Transplantacija bubrega najbolja je metoda liječenja bolesnika s uznapredovalom kroničnom bubrežnom bolešću. No, veliki se napori moraju uložiti kako bi se poboljšalo rano preživljenje presatka, osobito u slučaju presadaka dobivenih od umrlih darivatelja. Od svih čimbenika, hladna ishemija je vjerojatno jedini promjenjivi čimbenik koji može značajno utjecati na njihovo preživljenje. Smanjenjem trajanja hladne ishemije smanjuje se i mogućnost pojave odgođene funkcije presatka te posljedično akutnog odbacivanja presatka kao i smrtnosti primatelja. U radu ćemo prikazati mogući utjecaj hladne ishemije na preživljenje presadaka. Retrospektivno smo analizirali 155 pacijenata s uznapredovalom kroničnom bubrežnom bolešću koji su podvrgnuti transplantaciji bubrega na Klinici za urologiju KBC-a Rijeka u razdoblju od kolovoza 2007. godine do prosinca 2013. godine. Ispitanici su praćeni od 6 do 72 mjeseca kako bi se utvrdio utjecaj trajanja hladne ishemije na preživljenje presadaka. Od ukupno 155 ispitanika, njih 90 (58%) je bilo muškog, a 65 (42%) ženskog spola. Prosječna dob primatelja bila je 55 (15–78) godina. Samo je jedan presadak dobiven od živog (otac), dok su preostali dobiveni od mrtvih darivatelja. Nije bilo statistički značajne razlike u jednogodišnjem i petogodišnjem preživljenju presadaka izloženih 12, 18, odnosno 24-satnoj hladnoj ishemiji. Hladna ishemija je čimbenik koji značajno utječe na preživljenje presatka. Presadci transplantirani našim pacijentima izloženi su relativno kratkoj hladnoj ishemiji (16 sati i 6 minuta), ali potrebno je ograničiti trajanje hladne ishemije do najviše 24 sata kako bi rizik akutnog odbacivanja presatka bio što manji.
Keywordskidney transplantation end-stage renal disease graft survival cold ischemia time delayed graft function
Committee MembersRomano Oguić (committee chairperson)
Josip Španjol (committee member)
Ivan Bubić (committee member)
GranterSveučilište u Rijeci
Medicinski fakultet
Lower level organizational unitsKatedra za kirurgiju
PlaceRijeka
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmeMedicine
Academic title abbreviationdr. med.
Genremaster's thesis
Language Croatian
Defense date2016-07-15
Parallel abstract (English)
Kidney transplantation represents the best method of treatment for patients with end-stage renal disease. However, big efforts should be done to improve early graft survival, especially in the case of grafts obtained from deceased donors. Cold ischemia time is probably the only variable factor that can significantly affect the graft survival. Delayed graft function probability and the consequent acute graft rejection as well as recipient mortality are reduced by lower cold ischemia time. This study demonstrates the potential influence of cold ischemia time on graft survival. We have retrospectively analyzed 155 patients with end-stage renal disease who underwent kidney transplantation from August 2007 to December 2013 at Department of Urology, University Hospital Rijeka. The recipients were observed from 6 to 72 months in order to determine the effect of cold ischemia time on graft survival. Of the total of 155 patients, 90 (58%) were male while 65 (42%) were female. The mean age of the recipients was 55 (15-78) years. Only one graft was obtained from a living (father) donor, while others were obtained from deceased donors. No statistically significant difference was found in one-year and five-year graft survival after 12, 18 and 24 hours of cold ischemia time. Cold ischemia time is a factor which significantly affects the graft survival. Grafts transplanted in our patients were exposed to relatively short cold ischemia time (16 hours and 6 minutes), but it should be limited to a maximum of 24 hours in order to reduce the acute graft rejection possibility.
Parallel keywords (Croatian)transplantacija bubrega uznapredovala kronična bubrežna bolest preživljenje presatka hladna ishemija odgođena funkcija presatka
Resource typetext
Access conditionAccess restricted to higher education institution's students and staff
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:570293
CommitterBosa Licul