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master's thesis
Kožne manifestacije endokrinih poremećaja

Virna Medanić (2016)
Metadata
TitleKožne manifestacije endokrinih poremećaja
AuthorVirna Medanić
Mentor(s)Sandra Peternel (thesis advisor)
Abstract
Endokrini poremećaji, preko manjka ili viška hormona, dovode do raznih funkcionalnih i morfoloških promjena kože što se očituje brojnom i kompleksnom simptomatologijom. U kožne manifestacije dijabetesa spadaju acanthosis nigricans, limitirajuća zglobna mobilnost i sklerodermiji sličan sindrom, scleredema diabeticorum, eruptivni ksantomi, dijabetičko stopalo, necrobiosis lipoidica, granuloma anulare, dijabetička dermopatija i bullosis diabeticorum. Klasični znak hipertireoze je tireoidna dermopatija. Pored toga, koža je topla i baršunasta, kosa tanka, a nokti mekani, sjajni i krhki. Miksedem je klasična manifestacija hipotireoze. Moguća je pojava alopecije, dok je koža redovito suha i hiperkeratotična. U hiperparatireoidizmu se rijetko javljaju kacinoza kože i kalcifilaksija, a u hipoparatireoidizmu koža je ljuskasta, hiperkeratotična i edematozna. Patognomonične za Cushingov sindrom su ljubičaste strije na abdomenu. Osim toga, uočava se kožna atrofija i hiperpigmentacija. Hiperpigmentacija je glavna kožna manifestacija Addisonove bolesti. Hipoestrogenizam uzrokuje kserozu i atrofiju kože, dok hiperestrogenizam ima suprotan učinak od toga. Moguća je pojava melazme kod viška estrogena. Višak androgena uzrokuje iznenadnu pojavu akni, hirzutizam i androgenu alopeciju. Akromegalija se manifestira zadebljanjem kože, kapaka, usana, nosa i stvaranjem suvišnih nabora na licu, pojačanim znojenjem, hirzutizmom i acanthosis nigricans. Karakteristika oboljelih od hipopituitarizma je bljedoća i atrofija kože, te nestanak aksilarne i pubične dlakavosti. Liječenje kožnih manifestacija endokrinih poremećaja je uglavnom ciljano i usmjereno na uzrok. U slučajevima manjka hormona, ono najčešće podrazumijeva medikamentnu nadoknadu hormona. Primarna terapija kod pretjeranog stvaranja hormona je kirurška.
Keywordsendocrine disorders diabetes acanthosis nigricans scleroderma-like syndrome scleredema diabeticorum eruptive xanthomas diabetic foot necrobiosis lipoidica granuloma annulare diabetic dermopathy bullosis diabeticorum hyperthyroidism thyroid dermopathy hypothyroidism myxedema hyperparathyroidism hypoparathyroidism Cushing syndrome Addison disease hyperestrogenism melasma hypoestrogenism acromegaly hypopituitarism
Committee MembersLarisa Prpić Massari (committee chairperson)
Edita Simonić (committee member)
Sanja Klobučar Majanović (committee member)
GranterSveučilište u Rijeci
Medicinski fakultet
Lower level organizational unitsKatedra za dermatovenerologiju
PlaceRijeka
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmeMedicine
Academic title abbreviationdr. med.
Genremaster's thesis
Language Croatian
Defense date2016-07-15
Parallel abstract (English)
Endocrine disorders, through deficiencies or excess of hormones, lead to various changes in cutaneous function and morphology that result in numerous and complex symptomatology. Cutaneous manifestations of diabetes include acanthosis nigricans, limited joint mobility and scleroderma-like syndrome, scleredema diabeticorum, eruptive xanthomas, diabetic foot, necrobiosis lipoidica, granuloma annulare, diabetic dermopathy and bullosis diabeticorum. The classic sign of hyperthyroidism is thyroid dermopathy. Besides that, skin is warm and velvety, hair is thin and nails become soft, shiny and brittle. Myxedema is a classic manifestation of hypothyroidism. Alopecia may be present while there is regularly dry and hyperkeratotic skin. Calcinosis cutis and calciphylaxis rarely occur in hyperparathyroidism whereas hypoparathyroidism is associated with scaly, hyperkeratotic and edematous skin. Violaceous striae on abdomen are pathognomonic of Cushing syndrome. Other clinical findings include skin atrophy and hyperpigmentation. Hyperpigmenation is the main cutaneous manifestation of Addison disease. Hypoestrogenism causes xerotic and atrophic skin, while hyperestrogenism has the opposite effect. Melasma can be associated with estrogen excess. Androgen excess can cause sudden onset of acne, hirsutism and androgenetic alopecia. Acromegaly manifests with thickened skin, eyelids, lips and nose, with deep grooves on the face, excessive sweating, hisutism and acanthosis nigricans. Patients with hypopituitarism are characterizied by pale and atrophic skin and loss of pubic and axillary hair. Treatment of cutaneous manifestations of endocrine disorders is mostly specific and etiologic. In cases of hormone deficiency, that means replacement therapy of hormones. The primary treatment of hormone excess includes surgical procedures
Parallel keywords (Croatian)endokrini poremećaji dijabetes acanthosis nigricans sklerodermiji sličan sindrom scleredema diabeticorum eruptivni ksantomi dijabetičko stopalo necrobiosis lipoidica granuloma anulare dijabetička dermopatija bullosis diabeticorum hipertireoza tireoidna dermopatija hipotireoza miksedem hiperparatireoidizam hipoparatireoidizam Cushingov sindrom Addisonova bolest hiperestrogenizam melazma hipoestrogenizam akromegalija hipopituitarizam
Resource typetext
Access conditionAccess restricted to higher education institution's students and staff
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:337712
CommitterBosa Licul