prikaz prve stranice dokumenta A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma
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Scientific paper - Original scientific paper
A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma
Experimental Biology and Medicine, 242 (2017), 15; 1553-1558. https://doi.org/10.1177/1535370217724093
Franzoni, Alessandra; Markova-Car, Elitza; Dević-Pavlić, Sanja; Jurišić, Davor; Puppin, Cinzia; Mio, Catia; De Luca, Marila; Petruz, Giulia; Damante, Giuseppe; Kraljević Pavelić, Sandra

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Franzoni, A., Markova Car, E., Dević Pavlić, S., Jurišić, D., Puppin, C., Mio, C. ... Kraljević Pavelić, S. (2017). A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma. Experimental Biology and Medicine, 242. (15), 1553-1558. doi: 10.1177/1535370217724093

Franzoni, Alessandra, et al. "A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma." Experimental Biology and Medicine, vol. 242, no. 15, 2017, pp. 1553-1558. https://doi.org/10.1177/1535370217724093

Franzoni, Alessandra, Elitza Markova Car, Sanja Dević Pavlić, Davor Jurišić, Cinzia Puppin, Catia Mio, Marila De Luca, Giulia Petruz, Giuseppe Damante and Sandra Kraljević Pavelić. "A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma." Experimental Biology and Medicine 242, no. 15 (2017): 1553-1558. https://doi.org/10.1177/1535370217724093

Franzoni, A., et al. (2017) 'A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma', Experimental Biology and Medicine, 242(15), pp. 1553-1558. doi: 10.1177/1535370217724093

Franzoni A, Markova Car E, Dević Pavlić S, Jurišić D, Puppin C, Mio C, and sur.. A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma. Experimental Biology and Medicine [Internet]. 2017 [cited 2024 November 17];242(15):1553-1558. doi: 10.1177/1535370217724093

A. Franzoni, et al., "A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma", Experimental Biology and Medicine, vol. 242, no. 15, pp. 1553-1558, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:966552. [Accessed: 17 November 2024]

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Metadata
Title (english)A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma
AuthorAlessandra Franzoni
AuthorElitza Markova-Car
AuthorSanja Dević-Pavlić
MBZ: 320360
AuthorDavor Jurišić
MBZ: 280602
AuthorCinzia Puppin
AuthorCatia Mio
AuthorMarila De Luca
AuthorGiulia Petruz
AuthorGiuseppe Damante
AuthorSandra Kraljević Pavelić
MBZ: 254965
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		INTERDISCIPLINARY AREAS OF KNOWLEDGE
Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
Circadian clock regulation in mammals is controlled by feedback loops of a set of circadian genes. One of these circadian genes, NPAS2, encodes for a member of the bHLH-PAS class of transcription factors and is expressed in the forebrain and in some peripheral organs such as liver and skin. Other biological processes are also regulated by circadian genes. For example, NPAS2 is involved in cell proliferation, DNA damage repair and malignant transformation. Aberrant expression of clock genes has been previously observed in melanoma which led to our effort to sequence the NPAS2 promoter region in this cancer type. The NPAS2 putative promoter and 5′ untranslated region of ninety-three melanoma patients and ninety-six control subjects were sequenced and several variants were identified. Among these is a novel microsatellite comprising a GGC repeat with different alleles ranging from 7 to 13 repeats located in the 5′ untranslated exon. Homozygosity of an allele with nine repeats (9/9) was more prevalent in melanoma than in control subjects (22.6% and 13.5%, respectively, P: 0.0206) suggesting that some NPAS2 variants might contribute to melanoma susceptibility.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleExperimental Biology and Medicine
Numberingvol. 242, no. 15, pp. 1553-1558
p-ISSN1535-3702
e-ISSN1535-3699
DOIhttps://doi.org/10.1177/1535370217724093
URN:NBNurn:nbn:hr:184:966552
Publication2017
Document URLhttp://bib.irb.hr/894974
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-02-03 10:43:06