Access restricted to higher education institution's students and staff
master's thesis
Endokrini uzroci hipertenzije

Morana Šangulin (2016)
Metadata
TitleEndokrini uzroci hipertenzije
AuthorMorana Šangulin
Mentor(s)Sanja Klobučar Majanović (thesis advisor)
Abstract
Arterijsku hipertenziju možemo podijeliti na primarnu i sekundarnu. Endokrini uzroci hipertenzije pripadaju skupini sekundarnih hipertenzija. Iako čine samo manji dio u ukupnoj prevalenciji hipertenzije nužno ih je pravovremeno prepoznati jer su potencijalno izlječivi. Najpovoljnije liječenje endokrine hipertenzije je upravo rješavanje same endokrinološke patologije, posebno kirurškim pristupom. U tu skupinu ulaze primarni aldesteronizam, Cushingov sindrom, feokromocitom, akromegalija, hipo/hipertireoza i sl. Primarni aldosteronizam je najčešći oblik endokrine hipertenzije s prevalencijom 5-13% u hipertoničara. To je skupina poremećaja karakterizirana visokom sekrecijom aldosterona, hipertenzijom, hipokalijemijom, hipernatrijemijom, metaboličkom acidozom. Hipersekrecija aldosterona izaziva hipertenziju djelovanjem na više organskih sustava. Metoda liječenja unilateralnog PA je laparoskopska ekstirpacija adenoma ili žlijezde žlijezde, a bilateralnog antagonistima mineralokortikoidnih receptora. U Cushingovom sindrom nalazimo previsoke koncentracije hormona kore nadbubrežne žlijezde. Karakteristični simptomi hiperkortizolizma su purpurne strije, atrofija kože, okruglo lice, proksimalna mišićna slabost. Arterijska hipertenzija složene je etiologije i javlja se u oko 80% pacijenata sa Cushingovim sindromom. Liječenje je u prvom redu kirurško. Feokromocitomi su rijetki tumori kromafinih stanica koji luče katekolamine. Klasični trijas simptoma sastoji se od glavobolje, pojačanog znojenja i palpitacija. Trećina pacijenata ima paroksizmalnu hipertenziju, polovina perzistentnu, ostali mogu biti normotenzivni. Liječenje je kirurško, medikamentna terapija prije same operacije ima veliku važnost kako bi se izbjegle potencijalno fatalne hipertenzivne krize. Akromegalija je rijedak uzrok hipertenzije, to je kronična bolest karakterizirana ekscesivnom sekrecijom hormona rasta. Arterijska hipertenzija javlja su u 40% bolesnika, dominatno je povišen dijastolički tlak.
Committee MembersIvan Bubić (committee chairperson)
Antica Duletić-Načinović (committee member)
Ines Mrakovčić-Šutić (committee member)
GranterSveučilište u Rijeci
Medicinski fakultet
Lower level organizational unitsKatedra za internu medicinu
PlaceRijeka
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmeMedicine
Academic title abbreviationdr. med.
Genremaster's thesis
Language Croatian
Defense date2016-07-15
Parallel abstract (English)
Hypertension can be divided into primary and secondary. The endocrine causes of hypertension are primary aldosteronism, Cushing's syndrome, pheochromocytoma, acromegaly, hypo/hyperthyroidism etc. They are classed as secondary hypertension. Although they account for only a small part of the overall prevalence of hypertension it is very important to diagnose them because they are potentally curable. The best treatment approach for endocrine hypertension is treating its cause (endocrine pathology), especially by surgery. Primary aldosteronism is the most common form with prevalence of 5-13% in hypertensive patients. It is a group of disorders characterized by excessive aldosterone secretion, hypertension, hypokalemia, hypernatremia and metabolic acidosis. Aldosterone hypersecretion induces hypertension by affecting several organ systems. Laparoscopic removal of adenoma or entire gland represents the elective treatment in unilateral PA variants. Patients with bilateral autonomous aldosterone production should be treated with mineralocorticoid receptor blockers. Cushing's syndrome is characterized by excessive secretion of hormones produced in the adrenal cortex. Characteristic symptoms of hypercortisolism are stretch marks, skin atrophy, moon face and proximal muscle weakness. The etiology of arterial hypertension is complex and it occurs in approximately 80% of patients with Cushing's syndrome. Pheochromocytomas are rare catecholamine-secreting tumors. The classic triad of symptoms consist of headaches, excessive sweating and palpitations. One third of patients have paroxysmal hypertension, half have persistent, and others may be normotensive. Surgical resection of the tumor is the treatment of choice. Careful preoperative management is required to control blood pressure and prevent intraoperative hypertensive crises. Acromegaly is a rare cause of hypertension, it is a chronic disease characterized by excessive secretion of growth hormone. Hypertension occurs in 40% of patients with predominantly elevated diastolic pressure.
Parallel keywords (Croatian)arterijska hipertenzija endokrini uzroci hipertenzije Primarni aldosteronizam Cushingov sindrom feokromocitom akromegalija
Resource typetext
Access conditionAccess restricted to higher education institution's students and staff
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:315784
CommitterBosa Licul